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Successful treatment of septic shock and respiratory failure due to leptospirosis and scrub typhus coinfection with penicillin, levofloxacin, and activated protein C.
J Microbiol Immunol Infect 2012; 45(3):251-4JM

Abstract

Leptospirosis and scrub typhus are common zoonoses and coinfection with both diseases has been reported sporadically, particularly in tropical and subtropical areas. A 53-year-old male presented with acute hypoxemic respiratory failure and septic shock due to leptospirosis and scrub typhus coinfection confirmed by serological assessments. Antibiotics, including intravenous penicillin and levofloxacin, were administered and human recombinant activated protein C was added because of a high risk of death due to septic shock with multiple organ failure. The patient's hemodynamics and hypoxemia substantially improved 4 days later and he had a complete recovery from the disease after 10 days of hospitalization. Coinfection of leptospirosis and scrub typhus may easily go unrecognized by physicians in febrile travelers or patients in the region where both diseases are endemic. In severe and critical cases of leptospirosis, scrub typhus, or coinfection with both, the use of APC in addition to appropriate antibiotic treatment and standard critical care might provide a greater chance for survival and a favorable outcome.

Authors+Show Affiliations

Division of Pulmonary Medicine, Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung County, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22153761

Citation

Wei, Yu-Feng, et al. "Successful Treatment of Septic Shock and Respiratory Failure Due to Leptospirosis and Scrub Typhus Coinfection With Penicillin, Levofloxacin, and Activated Protein C." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 45, no. 3, 2012, pp. 251-4.
Wei YF, Chiu CT, Lai YF, et al. Successful treatment of septic shock and respiratory failure due to leptospirosis and scrub typhus coinfection with penicillin, levofloxacin, and activated protein C. J Microbiol Immunol Infect. 2012;45(3):251-4.
Wei, Y. F., Chiu, C. T., Lai, Y. F., Lai, C. H., & Lin, H. H. (2012). Successful treatment of septic shock and respiratory failure due to leptospirosis and scrub typhus coinfection with penicillin, levofloxacin, and activated protein C. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 45(3), pp. 251-4. doi:10.1016/j.jmii.2011.09.015.
Wei YF, et al. Successful Treatment of Septic Shock and Respiratory Failure Due to Leptospirosis and Scrub Typhus Coinfection With Penicillin, Levofloxacin, and Activated Protein C. J Microbiol Immunol Infect. 2012;45(3):251-4. PubMed PMID: 22153761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of septic shock and respiratory failure due to leptospirosis and scrub typhus coinfection with penicillin, levofloxacin, and activated protein C. AU - Wei,Yu-Feng, AU - Chiu,Chien-Tung, AU - Lai,Yung-Fa, AU - Lai,Chung-Hsu, AU - Lin,Hsi-Hsun, Y1 - 2011/12/06/ PY - 2010/12/12/received PY - 2011/03/10/revised PY - 2011/06/01/accepted PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/12/10/medline SP - 251 EP - 4 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 45 IS - 3 N2 - Leptospirosis and scrub typhus are common zoonoses and coinfection with both diseases has been reported sporadically, particularly in tropical and subtropical areas. A 53-year-old male presented with acute hypoxemic respiratory failure and septic shock due to leptospirosis and scrub typhus coinfection confirmed by serological assessments. Antibiotics, including intravenous penicillin and levofloxacin, were administered and human recombinant activated protein C was added because of a high risk of death due to septic shock with multiple organ failure. The patient's hemodynamics and hypoxemia substantially improved 4 days later and he had a complete recovery from the disease after 10 days of hospitalization. Coinfection of leptospirosis and scrub typhus may easily go unrecognized by physicians in febrile travelers or patients in the region where both diseases are endemic. In severe and critical cases of leptospirosis, scrub typhus, or coinfection with both, the use of APC in addition to appropriate antibiotic treatment and standard critical care might provide a greater chance for survival and a favorable outcome. SN - 1995-9133 UR - https://www.unboundmedicine.com/medline/citation/22153761/Successful_treatment_of_septic_shock_and_respiratory_failure_due_to_leptospirosis_and_scrub_typhus_coinfection_with_penicillin_levofloxacin_and_activated_protein_C_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1684-1182(11)00170-8 DB - PRIME DP - Unbound Medicine ER -