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Indoor tanning and risk of early-onset basal cell carcinoma.
J Am Acad Dermatol. 2012 Oct; 67(4):552-62.JA

Abstract

BACKGROUND

Despite an increase in incidence of basal cell carcinoma (BCC) among young people and the ubiquity of indoor tanning in this population, few epidemiologic studies have investigated this exposure-disease relationship.

OBJECTIVE

We sought to evaluate the association between indoor tanning and early-onset BCC.

METHODS

Patients with BCC (n = 376) and control subjects with minor benign skin conditions (n = 390) who were younger than 40 years of age were identified through Yale Dermatopathology. Participants provided information on ever indoor tanning, age of initiation, frequency, duration, burns while tanning, and type of tanning device during an in-person interview. We calculated odds ratios (OR) and 95% confidence intervals (CI) using multivariate logistic regression with never indoor tanners as the referent group.

RESULTS

Ever indoor tanning was associated with a 69% increased risk of early-onset BCC (95% CI 1.15-2.48). This association was stronger among females (OR 2.14, 95% CI 1.31-3.47), for multiple BCCs (OR 2.16, 95% CI 1.26-3.70), and for BCCs on the trunk and extremities (OR 2.81, 95% CI 1.57-5.02). Risk increased dose dependently with years using regular indoor tanning devices (P trend = .003), number of overall burns (P trend < .001), and burns to biopsy site (P trend < .001) from indoor tanning. Approximately one quarter (27%) of early-onset BCCs (or 43% among women) could be prevented if individuals never tanned indoors.

LIMITATIONS

Potential recall bias of indoor tanning by patients and generalizability of the control population suggest replication in other studies is warranted.

CONCLUSIONS

Indoor tanning was a strong risk factor for early-onset BCC, particularly among females. Indoor tanning should continue to be targeted by both policy-based and behavioral interventions, as the impact on BCC-associated morbidity may be substantial.

Authors+Show Affiliations

Yale School of Public Health, New Haven, Connecticut 06520-8034, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22153793

Citation

Ferrucci, Leah M., et al. "Indoor Tanning and Risk of Early-onset Basal Cell Carcinoma." Journal of the American Academy of Dermatology, vol. 67, no. 4, 2012, pp. 552-62.
Ferrucci LM, Cartmel B, Molinaro AM, et al. Indoor tanning and risk of early-onset basal cell carcinoma. J Am Acad Dermatol. 2012;67(4):552-62.
Ferrucci, L. M., Cartmel, B., Molinaro, A. M., Leffell, D. J., Bale, A. E., & Mayne, S. T. (2012). Indoor tanning and risk of early-onset basal cell carcinoma. Journal of the American Academy of Dermatology, 67(4), 552-62. https://doi.org/10.1016/j.jaad.2011.11.940
Ferrucci LM, et al. Indoor Tanning and Risk of Early-onset Basal Cell Carcinoma. J Am Acad Dermatol. 2012;67(4):552-62. PubMed PMID: 22153793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indoor tanning and risk of early-onset basal cell carcinoma. AU - Ferrucci,Leah M, AU - Cartmel,Brenda, AU - Molinaro,Annette M, AU - Leffell,David J, AU - Bale,Allen E, AU - Mayne,Susan T, Y1 - 2011/12/09/ PY - 2011/09/14/received PY - 2011/11/10/revised PY - 2011/11/11/accepted PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/12/10/medline SP - 552 EP - 62 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 67 IS - 4 N2 - BACKGROUND: Despite an increase in incidence of basal cell carcinoma (BCC) among young people and the ubiquity of indoor tanning in this population, few epidemiologic studies have investigated this exposure-disease relationship. OBJECTIVE: We sought to evaluate the association between indoor tanning and early-onset BCC. METHODS: Patients with BCC (n = 376) and control subjects with minor benign skin conditions (n = 390) who were younger than 40 years of age were identified through Yale Dermatopathology. Participants provided information on ever indoor tanning, age of initiation, frequency, duration, burns while tanning, and type of tanning device during an in-person interview. We calculated odds ratios (OR) and 95% confidence intervals (CI) using multivariate logistic regression with never indoor tanners as the referent group. RESULTS: Ever indoor tanning was associated with a 69% increased risk of early-onset BCC (95% CI 1.15-2.48). This association was stronger among females (OR 2.14, 95% CI 1.31-3.47), for multiple BCCs (OR 2.16, 95% CI 1.26-3.70), and for BCCs on the trunk and extremities (OR 2.81, 95% CI 1.57-5.02). Risk increased dose dependently with years using regular indoor tanning devices (P trend = .003), number of overall burns (P trend < .001), and burns to biopsy site (P trend < .001) from indoor tanning. Approximately one quarter (27%) of early-onset BCCs (or 43% among women) could be prevented if individuals never tanned indoors. LIMITATIONS: Potential recall bias of indoor tanning by patients and generalizability of the control population suggest replication in other studies is warranted. CONCLUSIONS: Indoor tanning was a strong risk factor for early-onset BCC, particularly among females. Indoor tanning should continue to be targeted by both policy-based and behavioral interventions, as the impact on BCC-associated morbidity may be substantial. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/22153793/Indoor_tanning_and_risk_of_early_onset_basal_cell_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(11)02249-3 DB - PRIME DP - Unbound Medicine ER -