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Randomized trial of pterygium surgery with mitomycin C application using conjunctival autograft versus conjunctival-limbal autograft.
Ophthalmology. 2012 Feb; 119(2):227-32.O

Abstract

PURPOSE

To compare the outcomes of free conjunctival autograft (CAU) versus conjunctival-limbal autograft (CLAU) in the prevention of recurrence after pterygium surgery with adjunctive mitomycin C application in patients with primary or recurrent pterygia.

DESIGN

Prospective, randomized study.

PARTICIPANTS AND CONTROLS

Eighty-seven eyes of 86 patients with primary or recurrent nasal pterygia were included.

METHODS

All eyes underwent pterygium excision followed by removal of subconjunctival fibrovascular tissue and application of 0.02% mitomycin C for 3 minutes. The eyes then were assigned randomly to receive either CAU (44 eyes) or CLAU (43 eyes).

MAIN OUTCOME MEASURES

Rate of conjunctival or corneal recurrence of pterygium after surgery.

RESULTS

A follow-up of at least 12 months (mean, 14 ± 2.2 months) was achieved in 78 eyes of 78 patients, including 39 eyes in the CAU group (31 primary and 8 recurrent pterygia) and 39 eyes in the CLAU group (33 primary and 6 recurrent pterygia). After surgery, no eye in the CLAU group developed pterygium recurrence; however, recurrence was seen in 2 eyes (5.1%) in the CAU group, including 1 of 31 patients (3.2%) with primary pterygia and 1 of 8 patients (12.5%) with recurrent pterygia. There was no statistically significant difference in recurrence rates between the 2 groups or in the primary and recurrent subgroups. In the CLAU group, a localized pannus formation at the donor site of the limbal graft was noted in 5 eyes (12.8%), with the appearance of pseudopterygium in 1 eye.

CONCLUSIONS

There was no significant difference in recurrence rates of pterygium after surgery with mitomycin C application between the CAU and CLAU groups, more remarkably in primary cases. Limbal damage was seen in some eyes with CLAU.

Authors+Show Affiliations

Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran. Akheirkh@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22153864

Citation

Kheirkhah, Ahmad, et al. "Randomized Trial of Pterygium Surgery With Mitomycin C Application Using Conjunctival Autograft Versus Conjunctival-limbal Autograft." Ophthalmology, vol. 119, no. 2, 2012, pp. 227-32.
Kheirkhah A, Hashemi H, Adelpour M, et al. Randomized trial of pterygium surgery with mitomycin C application using conjunctival autograft versus conjunctival-limbal autograft. Ophthalmology. 2012;119(2):227-32.
Kheirkhah, A., Hashemi, H., Adelpour, M., Nikdel, M., Rajabi, M. B., & Behrouz, M. J. (2012). Randomized trial of pterygium surgery with mitomycin C application using conjunctival autograft versus conjunctival-limbal autograft. Ophthalmology, 119(2), 227-32. https://doi.org/10.1016/j.ophtha.2011.08.002
Kheirkhah A, et al. Randomized Trial of Pterygium Surgery With Mitomycin C Application Using Conjunctival Autograft Versus Conjunctival-limbal Autograft. Ophthalmology. 2012;119(2):227-32. PubMed PMID: 22153864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized trial of pterygium surgery with mitomycin C application using conjunctival autograft versus conjunctival-limbal autograft. AU - Kheirkhah,Ahmad, AU - Hashemi,Hassan, AU - Adelpour,Mohsen, AU - Nikdel,Mojgan, AU - Rajabi,Mohammad Bagher, AU - Behrouz,Mahmoud Jabbarvand, Y1 - 2011/12/06/ PY - 2011/04/11/received PY - 2011/08/01/revised PY - 2011/08/02/accepted PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/3/23/medline SP - 227 EP - 32 JF - Ophthalmology JO - Ophthalmology VL - 119 IS - 2 N2 - PURPOSE: To compare the outcomes of free conjunctival autograft (CAU) versus conjunctival-limbal autograft (CLAU) in the prevention of recurrence after pterygium surgery with adjunctive mitomycin C application in patients with primary or recurrent pterygia. DESIGN: Prospective, randomized study. PARTICIPANTS AND CONTROLS: Eighty-seven eyes of 86 patients with primary or recurrent nasal pterygia were included. METHODS: All eyes underwent pterygium excision followed by removal of subconjunctival fibrovascular tissue and application of 0.02% mitomycin C for 3 minutes. The eyes then were assigned randomly to receive either CAU (44 eyes) or CLAU (43 eyes). MAIN OUTCOME MEASURES: Rate of conjunctival or corneal recurrence of pterygium after surgery. RESULTS: A follow-up of at least 12 months (mean, 14 ± 2.2 months) was achieved in 78 eyes of 78 patients, including 39 eyes in the CAU group (31 primary and 8 recurrent pterygia) and 39 eyes in the CLAU group (33 primary and 6 recurrent pterygia). After surgery, no eye in the CLAU group developed pterygium recurrence; however, recurrence was seen in 2 eyes (5.1%) in the CAU group, including 1 of 31 patients (3.2%) with primary pterygia and 1 of 8 patients (12.5%) with recurrent pterygia. There was no statistically significant difference in recurrence rates between the 2 groups or in the primary and recurrent subgroups. In the CLAU group, a localized pannus formation at the donor site of the limbal graft was noted in 5 eyes (12.8%), with the appearance of pseudopterygium in 1 eye. CONCLUSIONS: There was no significant difference in recurrence rates of pterygium after surgery with mitomycin C application between the CAU and CLAU groups, more remarkably in primary cases. Limbal damage was seen in some eyes with CLAU. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/22153864/Randomized_trial_of_pterygium_surgery_with_mitomycin_C_application_using_conjunctival_autograft_versus_conjunctival_limbal_autograft_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(11)00746-9 DB - PRIME DP - Unbound Medicine ER -