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The APC-PCI concentration as an early marker of activation of blood coagulation: a study of women on combined oral contraceptives.
Thromb Res. 2012 Oct; 130(4):636-9.TR

Abstract

BACKGROUND

The risk of venous tromboembolism (VTE) in women taking combined oral contraceptives (COCs) is attributed to changes in coagulation and fibrinolysis. The impact of the COCs may be greater in women with preexisting thrombophilic defects. Nevertheless most women who suffer from venous thrombosis do not have any of the well known hereditary or acquired risk factors. A simple and sensitive marker of"thrombogenicity" has not been identified.

OBJECTIVES

To investigate the effects of two different monophasic combined oral contraceptives (COCs) on the plasma concentrations of activated protein C-inhibitor of protein C (APC-PCI) and on comparable hemostatic factors in fertile women.

METHOD

Forty four healthy nulliparous women with regular menstrual periods were included and randomly assigned to start with a monophasic preparation containing 30μg ethinylestradiol and 150μg levonogestrel (LNG/EE) or a preparation containing 30μg ethinylestradiol and 150 ug desogestrel (DG/EE). After a wash out period of two months, treatment with the alternate preparation was initiated and continued for two more cycles.

RESULTS

The plasma concentration of the APC-PCI complex and thrombin-antithrombin complex (TAT) increased during treatment with the two COCs. During DG/EE treatment the APC-PCI complex increased significantly more than during LNG/EE (p<0,01).The plasma concentration of D-dimer did not increase during OC treatment.

CONCLUSION

The APC-PCI complex concentration, which serves as a marker for thrombin generation and indicates hypercoagulability, was increased during COC treatment compared to baseline. The method is a sufficiently sensitive marker to detect even small differences in the activation of coagulation.

Authors+Show Affiliations

Department of Women´s and Children´s Health, Division of Obstetrics and Gynecology Karolinska Institutet, Stockholm, Sweden. Katarina.Bremme@karolinska.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22154243

Citation

Bremme, K, et al. "The APC-PCI Concentration as an Early Marker of Activation of Blood Coagulation: a Study of Women On Combined Oral Contraceptives." Thrombosis Research, vol. 130, no. 4, 2012, pp. 636-9.
Bremme K, Hamad RR, Berg E, et al. The APC-PCI concentration as an early marker of activation of blood coagulation: a study of women on combined oral contraceptives. Thromb Res. 2012;130(4):636-9.
Bremme, K., Hamad, R. R., Berg, E., Strandberg, K., & Stenflo, J. (2012). The APC-PCI concentration as an early marker of activation of blood coagulation: a study of women on combined oral contraceptives. Thrombosis Research, 130(4), 636-9. https://doi.org/10.1016/j.thromres.2011.11.006
Bremme K, et al. The APC-PCI Concentration as an Early Marker of Activation of Blood Coagulation: a Study of Women On Combined Oral Contraceptives. Thromb Res. 2012;130(4):636-9. PubMed PMID: 22154243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The APC-PCI concentration as an early marker of activation of blood coagulation: a study of women on combined oral contraceptives. AU - Bremme,K, AU - Hamad,R Rafik, AU - Berg,Elisabeth, AU - Strandberg,K, AU - Stenflo,J, Y1 - 2011/12/09/ PY - 2011/01/11/received PY - 2011/11/03/revised PY - 2011/11/07/accepted PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2013/2/6/medline SP - 636 EP - 9 JF - Thrombosis research JO - Thromb Res VL - 130 IS - 4 N2 - BACKGROUND: The risk of venous tromboembolism (VTE) in women taking combined oral contraceptives (COCs) is attributed to changes in coagulation and fibrinolysis. The impact of the COCs may be greater in women with preexisting thrombophilic defects. Nevertheless most women who suffer from venous thrombosis do not have any of the well known hereditary or acquired risk factors. A simple and sensitive marker of"thrombogenicity" has not been identified. OBJECTIVES: To investigate the effects of two different monophasic combined oral contraceptives (COCs) on the plasma concentrations of activated protein C-inhibitor of protein C (APC-PCI) and on comparable hemostatic factors in fertile women. METHOD: Forty four healthy nulliparous women with regular menstrual periods were included and randomly assigned to start with a monophasic preparation containing 30μg ethinylestradiol and 150μg levonogestrel (LNG/EE) or a preparation containing 30μg ethinylestradiol and 150 ug desogestrel (DG/EE). After a wash out period of two months, treatment with the alternate preparation was initiated and continued for two more cycles. RESULTS: The plasma concentration of the APC-PCI complex and thrombin-antithrombin complex (TAT) increased during treatment with the two COCs. During DG/EE treatment the APC-PCI complex increased significantly more than during LNG/EE (p<0,01).The plasma concentration of D-dimer did not increase during OC treatment. CONCLUSION: The APC-PCI complex concentration, which serves as a marker for thrombin generation and indicates hypercoagulability, was increased during COC treatment compared to baseline. The method is a sufficiently sensitive marker to detect even small differences in the activation of coagulation. SN - 1879-2472 UR - https://www.unboundmedicine.com/medline/citation/22154243/The_APC_PCI_concentration_as_an_early_marker_of_activation_of_blood_coagulation:_a_study_of_women_on_combined_oral_contraceptives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(11)00583-4 DB - PRIME DP - Unbound Medicine ER -