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Power loss and right ventricular efficiency in patients after tetralogy of Fallot repair with pulmonary insufficiency: clinical implications.
J Thorac Cardiovasc Surg. 2012 Jun; 143(6):1279-85.JT

Abstract

OBJECTIVES

To quantify right ventricular output power and efficiency and correlate these to ventricular function in patients with repaired tetralogy of Fallot. This might aid in determining the optimal timing for pulmonary valve replacement.

METHODS

We reviewed the cardiac catheterization and magnetic resonance imaging data of 13 patients with tetralogy of Fallot (age, 22 ± 17 years). Using pressure and flow measurements in the main pulmonary artery, cardiac output and regurgitation fraction, right ventricular (RV) power output, loss, and efficiency were calculated. The RV function was evaluated using cardiac magnetic resonance imaging.

RESULTS

The RV systolic power was 1.08 ± 0.62 W, with 20.3% ± 8.6% power loss owing to 41% ± 14% pulmonary regurgitation (efficiency, 79.7% ± 8.6%; 0.84 ± 0.73 W), resulting in a net cardiac output of 4.24 ± 1.82 L/min. Power loss correlated significantly with the indexed RV end-diastolic and end-systolic volume (R = 0.78, P = .002 and R = 0.69, P = .009, respectively). The normalized RV power output had a significant negative correlation with RV end-diastolic and end-systolic volumes (both R = -0.87, P = .002 and R = -0.68, P = .023, respectively). A rapid decrease occurred in the RV power capacity with an increasing RV volume, with the curve flattening out at an indexed RV end-diastolic and end-systolic volume threshold of 139 mL/m(2) and 75 mL/m(2), respectively.

CONCLUSIONS

Significant power loss is present in patients with repaired tetralogy of Fallot and pulmonary regurgitation. A rapid decrease in efficiency occurs with increasing RV volume, suggesting that pulmonary valve replacement should be done before the critical value of 139 mL/m(2) and 75 mL/m(2) for the RV end-diastolic and end-systolic volume, respectively, to preserve RV function.

Authors+Show Affiliations

Division of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. fogel@email.chop.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22154796

Citation

Fogel, Mark A., et al. "Power Loss and Right Ventricular Efficiency in Patients After Tetralogy of Fallot Repair With Pulmonary Insufficiency: Clinical Implications." The Journal of Thoracic and Cardiovascular Surgery, vol. 143, no. 6, 2012, pp. 1279-85.
Fogel MA, Sundareswaran KS, de Zelicourt D, et al. Power loss and right ventricular efficiency in patients after tetralogy of Fallot repair with pulmonary insufficiency: clinical implications. J Thorac Cardiovasc Surg. 2012;143(6):1279-85.
Fogel, M. A., Sundareswaran, K. S., de Zelicourt, D., Dasi, L. P., Pawlowski, T., Rome, J., & Yoganathan, A. P. (2012). Power loss and right ventricular efficiency in patients after tetralogy of Fallot repair with pulmonary insufficiency: clinical implications. The Journal of Thoracic and Cardiovascular Surgery, 143(6), 1279-85. https://doi.org/10.1016/j.jtcvs.2011.10.066
Fogel MA, et al. Power Loss and Right Ventricular Efficiency in Patients After Tetralogy of Fallot Repair With Pulmonary Insufficiency: Clinical Implications. J Thorac Cardiovasc Surg. 2012;143(6):1279-85. PubMed PMID: 22154796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Power loss and right ventricular efficiency in patients after tetralogy of Fallot repair with pulmonary insufficiency: clinical implications. AU - Fogel,Mark A, AU - Sundareswaran,Kartik S, AU - de Zelicourt,Diane, AU - Dasi,Lakshmi P, AU - Pawlowski,Tom, AU - Rome,Jack, AU - Yoganathan,Ajit P, Y1 - 2011/12/10/ PY - 2010/12/07/received PY - 2011/05/31/revised PY - 2011/10/24/accepted PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/7/12/medline SP - 1279 EP - 85 JF - The Journal of thoracic and cardiovascular surgery JO - J. Thorac. Cardiovasc. Surg. VL - 143 IS - 6 N2 - OBJECTIVES: To quantify right ventricular output power and efficiency and correlate these to ventricular function in patients with repaired tetralogy of Fallot. This might aid in determining the optimal timing for pulmonary valve replacement. METHODS: We reviewed the cardiac catheterization and magnetic resonance imaging data of 13 patients with tetralogy of Fallot (age, 22 ± 17 years). Using pressure and flow measurements in the main pulmonary artery, cardiac output and regurgitation fraction, right ventricular (RV) power output, loss, and efficiency were calculated. The RV function was evaluated using cardiac magnetic resonance imaging. RESULTS: The RV systolic power was 1.08 ± 0.62 W, with 20.3% ± 8.6% power loss owing to 41% ± 14% pulmonary regurgitation (efficiency, 79.7% ± 8.6%; 0.84 ± 0.73 W), resulting in a net cardiac output of 4.24 ± 1.82 L/min. Power loss correlated significantly with the indexed RV end-diastolic and end-systolic volume (R = 0.78, P = .002 and R = 0.69, P = .009, respectively). The normalized RV power output had a significant negative correlation with RV end-diastolic and end-systolic volumes (both R = -0.87, P = .002 and R = -0.68, P = .023, respectively). A rapid decrease occurred in the RV power capacity with an increasing RV volume, with the curve flattening out at an indexed RV end-diastolic and end-systolic volume threshold of 139 mL/m(2) and 75 mL/m(2), respectively. CONCLUSIONS: Significant power loss is present in patients with repaired tetralogy of Fallot and pulmonary regurgitation. A rapid decrease in efficiency occurs with increasing RV volume, suggesting that pulmonary valve replacement should be done before the critical value of 139 mL/m(2) and 75 mL/m(2) for the RV end-diastolic and end-systolic volume, respectively, to preserve RV function. SN - 1097-685X UR - https://www.unboundmedicine.com/medline/citation/22154796/Power_loss_and_right_ventricular_efficiency_in_patients_after_tetralogy_of_Fallot_repair_with_pulmonary_insufficiency:_clinical_implications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5223(11)01229-3 DB - PRIME DP - Unbound Medicine ER -