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JZTX-XIII, a Kv channel gating modifier toxin from Chinese tarantula Chilobrachys jingzhao.
Toxicon. 2012 Feb; 59(2):265-71.T

Abstract

Jingzhaotoxin-XIII (JZTX-XIII), a 35 residue polypeptide, with the ability to inhibit voltage-dependent potassium channels in the shab (Kv2) and shal (Kv4) subfamilies, was purified from the venom of the Chinese tarantula Chilobrachys jingzhao. Electrophysiological recordings carried out in Xenopus laevis oocytes showed that JZTX-XIII acted as gating modifier of voltage-dependent K+ channels which inhibited the Kv2.1 channel and Kv4.1 channel, with the IC50 value of 0.47 μM and 1.17 μM, respectively. JZTX-XIII shares high sequence similarity with gating modifier toxins inhibiting a wide variety of ion channels including Nav1.5 subtype, but it showed no Nav1.5 channel activity. Structure-function analysis indicates that the acidic residues of Glu10 and Glu17 in JZTX-XIII might be responsible for the loss of the Nav1.5 channel inhibitory potency for JZTX-XIII.

Authors+Show Affiliations

Department of Neurobiology, Southern Medical University, Guangzhou, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22155305

Citation

Yuan, Chunhua, et al. "JZTX-XIII, a Kv Channel Gating Modifier Toxin From Chinese Tarantula Chilobrachys Jingzhao." Toxicon : Official Journal of the International Society On Toxinology, vol. 59, no. 2, 2012, pp. 265-71.
Yuan C, Liu Z, Hu W, et al. JZTX-XIII, a Kv channel gating modifier toxin from Chinese tarantula Chilobrachys jingzhao. Toxicon. 2012;59(2):265-71.
Yuan, C., Liu, Z., Hu, W., Gao, T., & Liang, S. (2012). JZTX-XIII, a Kv channel gating modifier toxin from Chinese tarantula Chilobrachys jingzhao. Toxicon : Official Journal of the International Society On Toxinology, 59(2), 265-71. https://doi.org/10.1016/j.toxicon.2011.11.021
Yuan C, et al. JZTX-XIII, a Kv Channel Gating Modifier Toxin From Chinese Tarantula Chilobrachys Jingzhao. Toxicon. 2012;59(2):265-71. PubMed PMID: 22155305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - JZTX-XIII, a Kv channel gating modifier toxin from Chinese tarantula Chilobrachys jingzhao. AU - Yuan,Chunhua, AU - Liu,Zhonghua, AU - Hu,Weijun, AU - Gao,Tianming, AU - Liang,Songping, Y1 - 2011/12/08/ PY - 2011/06/16/received PY - 2011/10/22/revised PY - 2011/11/29/accepted PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/5/9/medline SP - 265 EP - 71 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 59 IS - 2 N2 - Jingzhaotoxin-XIII (JZTX-XIII), a 35 residue polypeptide, with the ability to inhibit voltage-dependent potassium channels in the shab (Kv2) and shal (Kv4) subfamilies, was purified from the venom of the Chinese tarantula Chilobrachys jingzhao. Electrophysiological recordings carried out in Xenopus laevis oocytes showed that JZTX-XIII acted as gating modifier of voltage-dependent K+ channels which inhibited the Kv2.1 channel and Kv4.1 channel, with the IC50 value of 0.47 μM and 1.17 μM, respectively. JZTX-XIII shares high sequence similarity with gating modifier toxins inhibiting a wide variety of ion channels including Nav1.5 subtype, but it showed no Nav1.5 channel activity. Structure-function analysis indicates that the acidic residues of Glu10 and Glu17 in JZTX-XIII might be responsible for the loss of the Nav1.5 channel inhibitory potency for JZTX-XIII. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/22155305/JZTX_XIII_a_Kv_channel_gating_modifier_toxin_from_Chinese_tarantula_Chilobrachys_jingzhao_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(11)00370-9 DB - PRIME DP - Unbound Medicine ER -