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Possible role of dopamine D1-like and D2-like receptors in behavioural activation and evaluation of response efficacy in the forced swimming test.
Neuropharmacology. 2012 Mar; 62(4):1717-29.N

Abstract

Based on the different effects of the dopamine D1-like and D2-like receptor antagonists SCH 23390 and raclopride on the measures of licking microstructure in rats ingesting a sucrose solution, we suggested that the behavioural activation of reward-associated responses depends on dopamine D1-like receptor stimulation, and its level is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated evaluation process. The aim of this study was to test this hypothesis on the forced swimming test response. The effects of the dopamine D1-like and D2-like receptor antagonists SCH 23390 (0.01-0.04 mg/kg) and raclopride (0.025-0.25 mg/kg) administered before a 15-min exposure to forced swimming, and the response to a second session performed 24 h later, were examined. SCH 23390 dose-dependently reduced climbing scores in the first session and increased them in the second session, but the within-session decline of this measure was similar to that observed in the control group in both sessions. Raclopride-treated subjects showed a slightly reduced level of climbing scores at the beginning of the first session, but persisted in emitting this costly behavioural response up to the end of the session, while no effects were observed in the second session. These results, along with our results examining licking for sucrose, are consistent with the hypothesis that behavioural activation and response effort allocation are directly mediated by dopamine D1-like receptor stimulation, but the level of this activation is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated mechanism of response efficacy evaluation.

Authors+Show Affiliations

Dipartimento di Scienze del Farmaco, Università di Sassari, Sassari, Italy. dsfpaolo@uniss.itNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22155445

Citation

D'Aquila, Paolo S., and Adriana Galistu. "Possible Role of Dopamine D1-like and D2-like Receptors in Behavioural Activation and Evaluation of Response Efficacy in the Forced Swimming Test." Neuropharmacology, vol. 62, no. 4, 2012, pp. 1717-29.
D'Aquila PS, Galistu A. Possible role of dopamine D1-like and D2-like receptors in behavioural activation and evaluation of response efficacy in the forced swimming test. Neuropharmacology. 2012;62(4):1717-29.
D'Aquila, P. S., & Galistu, A. (2012). Possible role of dopamine D1-like and D2-like receptors in behavioural activation and evaluation of response efficacy in the forced swimming test. Neuropharmacology, 62(4), 1717-29. https://doi.org/10.1016/j.neuropharm.2011.11.018
D'Aquila PS, Galistu A. Possible Role of Dopamine D1-like and D2-like Receptors in Behavioural Activation and Evaluation of Response Efficacy in the Forced Swimming Test. Neuropharmacology. 2012;62(4):1717-29. PubMed PMID: 22155445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible role of dopamine D1-like and D2-like receptors in behavioural activation and evaluation of response efficacy in the forced swimming test. AU - D'Aquila,Paolo S, AU - Galistu,Adriana, Y1 - 2011/12/06/ PY - 2011/07/03/received PY - 2011/10/31/revised PY - 2011/11/27/accepted PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/7/28/medline SP - 1717 EP - 29 JF - Neuropharmacology JO - Neuropharmacology VL - 62 IS - 4 N2 - Based on the different effects of the dopamine D1-like and D2-like receptor antagonists SCH 23390 and raclopride on the measures of licking microstructure in rats ingesting a sucrose solution, we suggested that the behavioural activation of reward-associated responses depends on dopamine D1-like receptor stimulation, and its level is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated evaluation process. The aim of this study was to test this hypothesis on the forced swimming test response. The effects of the dopamine D1-like and D2-like receptor antagonists SCH 23390 (0.01-0.04 mg/kg) and raclopride (0.025-0.25 mg/kg) administered before a 15-min exposure to forced swimming, and the response to a second session performed 24 h later, were examined. SCH 23390 dose-dependently reduced climbing scores in the first session and increased them in the second session, but the within-session decline of this measure was similar to that observed in the control group in both sessions. Raclopride-treated subjects showed a slightly reduced level of climbing scores at the beginning of the first session, but persisted in emitting this costly behavioural response up to the end of the session, while no effects were observed in the second session. These results, along with our results examining licking for sucrose, are consistent with the hypothesis that behavioural activation and response effort allocation are directly mediated by dopamine D1-like receptor stimulation, but the level of this activation is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated mechanism of response efficacy evaluation. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/22155445/Possible_role_of_dopamine_D1_like_and_D2_like_receptors_in_behavioural_activation_and_evaluation_of_response_efficacy_in_the_forced_swimming_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(11)00497-7 DB - PRIME DP - Unbound Medicine ER -