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The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.
J Clin Gastroenterol 2012; 46(3):220-7JC

Abstract

BACKGROUND

The clinical effect of probiotics on irritable bowel syndrome (IBS) is still controversial.

AIMS

We aimed to evaluate the effects of a probiotic mixture on IBS symptoms and the composition of fecal microbiota in patients with diarrhea-dominant IBS (D-IBS).

METHODS

Fifty patients with D-IBS were randomized into placebo or probiotic mixture (Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, and Streptococcus thermophilus 1.0×10 CFU) groups. Treatment was taken daily for 8 weeks. The primary outcome was adequate relief (AR) of overall IBS symptoms, which was assessed weekly for 10 weeks. A responder was defined as a patient who experienced AR for at least half of the 10-week study period. Secondary outcomes included the effects on individual symptoms, stool parameters, and IBS quality of life. The fecal flora compositions were analyzed by polymerase chain reaction denaturing gradient gel electrophoresis (DGGE).

RESULTS

The proportion of AR was consistently higher in the probiotics group than in the placebo group throughout the 10-week period (P<0.05). The proportion of responders was significantly higher in the probiotics group than in the placebo group (48% vs. 12%, P=0.01). Stool consistency improved significantly in the probiotics group compared with the placebo group. Percent changes in individual symptom scores were similar in the 2 groups, but IBS quality of life improvement tended to be higher in the probiotics group. Comparison of denaturing gradient gel electrophoresis profiles of fecal flora showed that the concordance rate between bacterial compositions before and after treatment was significantly higher in the probiotics group than in the placebo group (69.5% vs. 56.5%, P=0.005).

CONCLUSIONS

The probiotic mixture was effective in providing AR of overall IBS symptoms and improvement of stool consistency in D-IBS patients, although it had no significant effect on individual symptoms. The therapeutic effect of probiotics is associated with the stabilization of intestinal microbiota.

Authors+Show Affiliations

Department of Internal Medicine, Chung-Ang University College of Medicine, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22157240

Citation

Ki Cha, Bong, et al. "The Effect of a Multispecies Probiotic Mixture On the Symptoms and Fecal Microbiota in Diarrhea-dominant Irritable Bowel Syndrome: a Randomized, Double-blind, Placebo-controlled Trial." Journal of Clinical Gastroenterology, vol. 46, no. 3, 2012, pp. 220-7.
Ki Cha B, Mun Jung S, Hwan Choi C, et al. The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Gastroenterol. 2012;46(3):220-7.
Ki Cha, B., Mun Jung, S., Hwan Choi, C., Song, I. D., Woong Lee, H., Joon Kim, H., ... Seo, J. G. (2012). The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. Journal of Clinical Gastroenterology, 46(3), pp. 220-7. doi:10.1097/MCG.0b013e31823712b1.
Ki Cha B, et al. The Effect of a Multispecies Probiotic Mixture On the Symptoms and Fecal Microbiota in Diarrhea-dominant Irritable Bowel Syndrome: a Randomized, Double-blind, Placebo-controlled Trial. J Clin Gastroenterol. 2012;46(3):220-7. PubMed PMID: 22157240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. AU - Ki Cha,Bong, AU - Mun Jung,Seung, AU - Hwan Choi,Chang, AU - Song,In-Do, AU - Woong Lee,Hyun, AU - Joon Kim,Hyung, AU - Hyuk,Jae, AU - Kyung Chang,Sae, AU - Kim,Kijeong, AU - Chung,Won-Seok, AU - Seo,Jae-Gu, PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/6/20/medline SP - 220 EP - 7 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 46 IS - 3 N2 - BACKGROUND: The clinical effect of probiotics on irritable bowel syndrome (IBS) is still controversial. AIMS: We aimed to evaluate the effects of a probiotic mixture on IBS symptoms and the composition of fecal microbiota in patients with diarrhea-dominant IBS (D-IBS). METHODS: Fifty patients with D-IBS were randomized into placebo or probiotic mixture (Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, and Streptococcus thermophilus 1.0×10 CFU) groups. Treatment was taken daily for 8 weeks. The primary outcome was adequate relief (AR) of overall IBS symptoms, which was assessed weekly for 10 weeks. A responder was defined as a patient who experienced AR for at least half of the 10-week study period. Secondary outcomes included the effects on individual symptoms, stool parameters, and IBS quality of life. The fecal flora compositions were analyzed by polymerase chain reaction denaturing gradient gel electrophoresis (DGGE). RESULTS: The proportion of AR was consistently higher in the probiotics group than in the placebo group throughout the 10-week period (P<0.05). The proportion of responders was significantly higher in the probiotics group than in the placebo group (48% vs. 12%, P=0.01). Stool consistency improved significantly in the probiotics group compared with the placebo group. Percent changes in individual symptom scores were similar in the 2 groups, but IBS quality of life improvement tended to be higher in the probiotics group. Comparison of denaturing gradient gel electrophoresis profiles of fecal flora showed that the concordance rate between bacterial compositions before and after treatment was significantly higher in the probiotics group than in the placebo group (69.5% vs. 56.5%, P=0.005). CONCLUSIONS: The probiotic mixture was effective in providing AR of overall IBS symptoms and improvement of stool consistency in D-IBS patients, although it had no significant effect on individual symptoms. The therapeutic effect of probiotics is associated with the stabilization of intestinal microbiota. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/22157240/The_effect_of_a_multispecies_probiotic_mixture_on_the_symptoms_and_fecal_microbiota_in_diarrhea_dominant_irritable_bowel_syndrome:_a_randomized_double_blind_placebo_controlled_trial_ L2 - http://Insights.ovid.com/pubmed?pmid=22157240 DB - PRIME DP - Unbound Medicine ER -