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Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women.
Ann Neurol. 2011 Nov; 70(5):722-32.AN

Abstract

OBJECTIVE

Previous cross-sectional studies have observed alterations in activity rhythms in dementia patients but the direction of causation is unclear. We determined whether circadian activity rhythms measured in community-dwelling older women are prospectively associated with incident dementia or mild cognitive impairment (MCI).

METHODS

Activity rhythm data were collected from 1,282 healthy community-dwelling women from the Study of Osteoporotic Fractures (SOF) cohort (mean age 83 years) with wrist actigraphy for a minimum of three 24-hour periods. Each participant completed a neuropsychological test battery and had clinical cognitive status (dementia, MCI, normal) adjudicated by an expert panel approximately 5 years later. All analyses were adjusted for demographics, body mass index (BMI), functional status, depression, medications, alcohol, caffeine, smoking, health status, and comorbidities.

RESULTS

After 4.9 years of follow-up, 195 (15%) women had developed dementia and 302 (24%) had developed MCI. Older women with decreased activity rhythms had a higher likelihood of developing dementia or MCI when comparing those in the lowest quartiles of amplitude (odds ratio [OR] = 1.57; 95% CI, 1.09-2.25) or rhythm robustness (OR = 1.57; 95% CI, 1.10-2.26) to women in the highest quartiles. An increased risk of dementia or MCI (OR = 1.83; 95% CI, 1.29-2.61) was found for women whose timing of peak activity occurred later in the day (after 3:51 PM) when compared to those with average timing (1:34 PM-3:51 PM).

INTERPRETATION

Older, healthy women with decreased circadian activity rhythm amplitude and robustness, and delayed rhythms have increased odds of developing dementia and MCI. If confirmed, future studies should examine whether interventions (physical activity, bright light exposure) that influence activity rhythms will reduce the risk of cognitive deterioration in the elderly.

Authors+Show Affiliations

California Pacific Medical Center Research Institute, San Francisco, CA 94107-1728, USA. gtranah@sfcc-cpmc.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22162057

Citation

Tranah, Gregory J., et al. "Circadian Activity Rhythms and Risk of Incident Dementia and Mild Cognitive Impairment in Older Women." Annals of Neurology, vol. 70, no. 5, 2011, pp. 722-32.
Tranah GJ, Blackwell T, Stone KL, et al. Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Ann Neurol. 2011;70(5):722-32.
Tranah, G. J., Blackwell, T., Stone, K. L., Ancoli-Israel, S., Paudel, M. L., Ensrud, K. E., Cauley, J. A., Redline, S., Hillier, T. A., Cummings, S. R., & Yaffe, K. (2011). Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Annals of Neurology, 70(5), 722-32. https://doi.org/10.1002/ana.22468
Tranah GJ, et al. Circadian Activity Rhythms and Risk of Incident Dementia and Mild Cognitive Impairment in Older Women. Ann Neurol. 2011;70(5):722-32. PubMed PMID: 22162057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. AU - Tranah,Gregory J, AU - Blackwell,Terri, AU - Stone,Katie L, AU - Ancoli-Israel,Sonia, AU - Paudel,Misti L, AU - Ensrud,Kristine E, AU - Cauley,Jane A, AU - Redline,Susan, AU - Hillier,Teresa A, AU - Cummings,Steven R, AU - Yaffe,Kristine, AU - ,, PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/2/10/medline SP - 722 EP - 32 JF - Annals of neurology JO - Ann. Neurol. VL - 70 IS - 5 N2 - OBJECTIVE: Previous cross-sectional studies have observed alterations in activity rhythms in dementia patients but the direction of causation is unclear. We determined whether circadian activity rhythms measured in community-dwelling older women are prospectively associated with incident dementia or mild cognitive impairment (MCI). METHODS: Activity rhythm data were collected from 1,282 healthy community-dwelling women from the Study of Osteoporotic Fractures (SOF) cohort (mean age 83 years) with wrist actigraphy for a minimum of three 24-hour periods. Each participant completed a neuropsychological test battery and had clinical cognitive status (dementia, MCI, normal) adjudicated by an expert panel approximately 5 years later. All analyses were adjusted for demographics, body mass index (BMI), functional status, depression, medications, alcohol, caffeine, smoking, health status, and comorbidities. RESULTS: After 4.9 years of follow-up, 195 (15%) women had developed dementia and 302 (24%) had developed MCI. Older women with decreased activity rhythms had a higher likelihood of developing dementia or MCI when comparing those in the lowest quartiles of amplitude (odds ratio [OR] = 1.57; 95% CI, 1.09-2.25) or rhythm robustness (OR = 1.57; 95% CI, 1.10-2.26) to women in the highest quartiles. An increased risk of dementia or MCI (OR = 1.83; 95% CI, 1.29-2.61) was found for women whose timing of peak activity occurred later in the day (after 3:51 PM) when compared to those with average timing (1:34 PM-3:51 PM). INTERPRETATION: Older, healthy women with decreased circadian activity rhythm amplitude and robustness, and delayed rhythms have increased odds of developing dementia and MCI. If confirmed, future studies should examine whether interventions (physical activity, bright light exposure) that influence activity rhythms will reduce the risk of cognitive deterioration in the elderly. SN - 1531-8249 UR - https://www.unboundmedicine.com/medline/citation/22162057/Circadian_activity_rhythms_and_risk_of_incident_dementia_and_mild_cognitive_impairment_in_older_women_ L2 - https://doi.org/10.1002/ana.22468 DB - PRIME DP - Unbound Medicine ER -