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Pancreatic cancer risk: associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort.
Mol Carcinog 2012; 51(1):128-37MC

Abstract

BACKGROUND

Epidemiological studies report positive associations between high-temperature cooked meat intake and pancreatic cancer. We assessed associations between dietary intake of heterocyclic amines (HCAs) and benzo(a)pyrene (BaP)-mutagens formed in meat cooked at high temperatures-and incident exocrine pancreatic cancer in a prospective cohort.

METHODS

The 62 581 subjects randomized to screening in the Prostate, Lung, Colorectal, and Ovarian Screening Trial (PLCO) who completed an initial dietary survey that assessed meat intake, cooking methods, and doneness preferences defined the cohort. Subjects were surveyed annually for incident cancers through 2007. A National Cancer Institute research database (CHARRED) was used to estimate HCA and BaP intake and a Mutagenic Activity Index (MAI) from survey data. Proportional hazard ratios (HRs) for risk of pancreatic cancer were estimated from multi-variate Cox regression models by quintile of intake, with the lowest quintile as the referent.

RESULTS

During follow-up (median: 10 yr), 248 cases of exocrine pancreatic cancer were confirmed. Preferences for well and very well done meat were generally associated with increased risks. Significant elevations in pancreatic cancer risk were found in upper quintiles of MAI, and individual mutagens 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Compared to the lowest quintile of MAI, the third and fifth quintiles brought HRs of 1.86 (1.22, 2.85) and 1.87 (1.16, 3.02), respectively. These three exposures exhibited significant (P-trend: 0.01-0.03) positive trends in risk as their levels increased

CONCLUSION

Consuming well-done meat cooked at high temperatures, which contains high mutagen levels, appears to confer increased risk of pancreatic cancer.

Authors+Show Affiliations

Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota 55454, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22162237

Citation

Anderson, Kristin E., et al. "Pancreatic Cancer Risk: Associations With Meat-derived Carcinogen Intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort." Molecular Carcinogenesis, vol. 51, no. 1, 2012, pp. 128-37.
Anderson KE, Mongin SJ, Sinha R, et al. Pancreatic cancer risk: associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Mol Carcinog. 2012;51(1):128-37.
Anderson, K. E., Mongin, S. J., Sinha, R., Stolzenberg-Solomon, R., Gross, M. D., Ziegler, R. G., ... Church, T. R. (2012). Pancreatic cancer risk: associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Molecular Carcinogenesis, 51(1), pp. 128-37. doi:10.1002/mc.20794.
Anderson KE, et al. Pancreatic Cancer Risk: Associations With Meat-derived Carcinogen Intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort. Mol Carcinog. 2012;51(1):128-37. PubMed PMID: 22162237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic cancer risk: associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. AU - Anderson,Kristin E, AU - Mongin,Steven J, AU - Sinha,Rashmi, AU - Stolzenberg-Solomon,Rachael, AU - Gross,Myron D, AU - Ziegler,Regina G, AU - Mabie,Jerome E, AU - Risch,Adam, AU - Kazin,Sally S, AU - Church,Timothy R, PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/1/31/medline SP - 128 EP - 37 JF - Molecular carcinogenesis JO - Mol. Carcinog. VL - 51 IS - 1 N2 - BACKGROUND: Epidemiological studies report positive associations between high-temperature cooked meat intake and pancreatic cancer. We assessed associations between dietary intake of heterocyclic amines (HCAs) and benzo(a)pyrene (BaP)-mutagens formed in meat cooked at high temperatures-and incident exocrine pancreatic cancer in a prospective cohort. METHODS: The 62 581 subjects randomized to screening in the Prostate, Lung, Colorectal, and Ovarian Screening Trial (PLCO) who completed an initial dietary survey that assessed meat intake, cooking methods, and doneness preferences defined the cohort. Subjects were surveyed annually for incident cancers through 2007. A National Cancer Institute research database (CHARRED) was used to estimate HCA and BaP intake and a Mutagenic Activity Index (MAI) from survey data. Proportional hazard ratios (HRs) for risk of pancreatic cancer were estimated from multi-variate Cox regression models by quintile of intake, with the lowest quintile as the referent. RESULTS: During follow-up (median: 10 yr), 248 cases of exocrine pancreatic cancer were confirmed. Preferences for well and very well done meat were generally associated with increased risks. Significant elevations in pancreatic cancer risk were found in upper quintiles of MAI, and individual mutagens 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Compared to the lowest quintile of MAI, the third and fifth quintiles brought HRs of 1.86 (1.22, 2.85) and 1.87 (1.16, 3.02), respectively. These three exposures exhibited significant (P-trend: 0.01-0.03) positive trends in risk as their levels increased CONCLUSION: Consuming well-done meat cooked at high temperatures, which contains high mutagen levels, appears to confer increased risk of pancreatic cancer. SN - 1098-2744 UR - https://www.unboundmedicine.com/medline/citation/22162237/Pancreatic_cancer_risk:_associations_with_meat_derived_carcinogen_intake_in_the_Prostate_Lung_Colorectal_and_Ovarian_Cancer_Screening_Trial__PLCO__cohort_ L2 - https://doi.org/10.1002/mc.20794 DB - PRIME DP - Unbound Medicine ER -