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Synthesis of biocompatible poly(ɛ-caprolactone)- block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles.
Int J Nanomedicine 2011; 6:2981-95IJ

Abstract

Poly(propylene adipate)-block-poly(ɛ-caprolactone) copolymers were synthesized using a combination of polycondensation and ring-opening polymerization of ɛ-caprolactone in the presence of poly(propylene adipate). Gel permeation chromatography was used for molecular weight determination, whereas hydrogen-1 nuclear magnetic resonance and carbon-13 nuclear magnetic resonance spectroscopy were employed for copolymer characterization and composition evaluation. The copolymers were found to be block while their composition was similar to the feeding ratio. They formed semicrystalline structures, while only poly(ɛ-caprolactone) formed crystals, as shown by wide angle X-ray diffraction. Differential scanning calorimetry data suggest that the melting point and heat of fusion of copolymers decreased by increasing the poly(propylene adipate) amount. The synthesized polymers exhibited low cytotoxicity and were used to encapsulate desferrioxamine, an iron-chelating drug. The desferrioxamine nanoparticles were self-assembled into core shell structures, had mean particle size <250 nm, and the drug remained in crystalline form. Further studies revealed that the dissolution rate was mainly related to the melting temperature, as well as to the degree of crystallinity of copolymers.

Authors+Show Affiliations

Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22162656

Citation

Nanaki, Stavroula G., et al. "Synthesis of Biocompatible Poly(ɛ-caprolactone)- Block-poly(propylene Adipate) Copolymers Appropriate for Drug Nanoencapsulation in the Form of Core-shell Nanoparticles." International Journal of Nanomedicine, vol. 6, 2011, pp. 2981-95.
Nanaki SG, Pantopoulos K, Bikiaris DN. Synthesis of biocompatible poly(ɛ-caprolactone)- block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles. Int J Nanomedicine. 2011;6:2981-95.
Nanaki, S. G., Pantopoulos, K., & Bikiaris, D. N. (2011). Synthesis of biocompatible poly(ɛ-caprolactone)- block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles. International Journal of Nanomedicine, 6, pp. 2981-95. doi:10.2147/IJN.S26568.
Nanaki SG, Pantopoulos K, Bikiaris DN. Synthesis of Biocompatible Poly(ɛ-caprolactone)- Block-poly(propylene Adipate) Copolymers Appropriate for Drug Nanoencapsulation in the Form of Core-shell Nanoparticles. Int J Nanomedicine. 2011;6:2981-95. PubMed PMID: 22162656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of biocompatible poly(ɛ-caprolactone)- block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles. AU - Nanaki,Stavroula G, AU - Pantopoulos,Kostas, AU - Bikiaris,Dimitrios N, Y1 - 2011/11/22/ PY - 2011/12/14/entrez PY - 2011/12/14/pubmed PY - 2012/6/22/medline KW - biocompatible polyesters KW - desferrioxamine KW - drug encapsulation KW - poly(propylene adipate) KW - poly(ɛ-caprolactone) SP - 2981 EP - 95 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 6 N2 - Poly(propylene adipate)-block-poly(ɛ-caprolactone) copolymers were synthesized using a combination of polycondensation and ring-opening polymerization of ɛ-caprolactone in the presence of poly(propylene adipate). Gel permeation chromatography was used for molecular weight determination, whereas hydrogen-1 nuclear magnetic resonance and carbon-13 nuclear magnetic resonance spectroscopy were employed for copolymer characterization and composition evaluation. The copolymers were found to be block while their composition was similar to the feeding ratio. They formed semicrystalline structures, while only poly(ɛ-caprolactone) formed crystals, as shown by wide angle X-ray diffraction. Differential scanning calorimetry data suggest that the melting point and heat of fusion of copolymers decreased by increasing the poly(propylene adipate) amount. The synthesized polymers exhibited low cytotoxicity and were used to encapsulate desferrioxamine, an iron-chelating drug. The desferrioxamine nanoparticles were self-assembled into core shell structures, had mean particle size <250 nm, and the drug remained in crystalline form. Further studies revealed that the dissolution rate was mainly related to the melting temperature, as well as to the degree of crystallinity of copolymers. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/22162656/Synthesis_of_biocompatible_poly_ɛ_caprolactone___block_poly_propylene_adipate__copolymers_appropriate_for_drug_nanoencapsulation_in_the_form_of_core_shell_nanoparticles_ L2 - https://dx.doi.org/10.2147/IJN.S26568 DB - PRIME DP - Unbound Medicine ER -