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Isolation of the volatile oil from Satureja thymbra by supercritical carbon dioxide extraction: chemical composition and biological activity.
Nat Prod Commun. 2011 Oct; 6(10):1523-6.NP

Abstract

Satureja thymbra L. is well known in Italy by the popular name of "Santoreggia sarda". It grows only in Sardinia and nowadays it is restricted to the slope of the Colle San Michele in Cagliari. The composition of the aromatic extracts obtained by supercritical CO2 and by hydrodistillation and their antifungal activity is reported. The collected extracts were analyzed by GC-FID and GC-MS methods. No significant differences were observed in the composition of the volatile extracts depending on the extraction method. The results showed the presence of thymol, gamma-terpinene, beta-caryophyllene, p-cymene, carvacrol and borneol as main components. The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida albicans, C. tropicalis, C. krusei, C. guillermondii, C. parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, T. mentagrophytes, T. mentagrophytes var. interdigitale, Trichophyton rubrum, T. verrucosum, Microsporum canis, M. gypseum, Epidermophyton floccosum, Aspergillus niger, A. fumigatus and A. flavus. The volatile extracts revealed a wide-spectrum antifungal activity. They were fungicidal and similarly potent against yeasts, dermatophyte and Aspergillus stains, with MICs ranging from 0.16 to 0.32 pL x mL(-1).

Authors+Show Affiliations

Piras A
Dipartimento di Scienze Chimiche, Università degli Studi di Cagliari, Cittadella Universitaria di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy. apiras@unica.it
Cocco V
No affiliation info available
Falconieri D
No affiliation info available
Porcedda S
No affiliation info available
Marongiu B
No affiliation info available
Maxia A
No affiliation info available
Frau MA
No affiliation info available
Gonçalves MJ
No affiliation info available
Cavaleiro C
No affiliation info available
Salgueiro L
No affiliation info available

MeSH

Carbon DioxideChromatography, Supercritical FluidOils, VolatilePlant OilsSatureja

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22164799

Citation

Piras, Alessandra, et al. "Isolation of the Volatile Oil From Satureja Thymbra By Supercritical Carbon Dioxide Extraction: Chemical Composition and Biological Activity." Natural Product Communications, vol. 6, no. 10, 2011, pp. 1523-6.
Piras A, Cocco V, Falconieri D, et al. Isolation of the volatile oil from Satureja thymbra by supercritical carbon dioxide extraction: chemical composition and biological activity. Nat Prod Commun. 2011;6(10):1523-6.
Piras, A., Cocco, V., Falconieri, D., Porcedda, S., Marongiu, B., Maxia, A., Frau, M. A., Gonçalves, M. J., Cavaleiro, C., & Salgueiro, L. (2011). Isolation of the volatile oil from Satureja thymbra by supercritical carbon dioxide extraction: chemical composition and biological activity. Natural Product Communications, 6(10), 1523-6.
Piras A, et al. Isolation of the Volatile Oil From Satureja Thymbra By Supercritical Carbon Dioxide Extraction: Chemical Composition and Biological Activity. Nat Prod Commun. 2011;6(10):1523-6. PubMed PMID: 22164799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation of the volatile oil from Satureja thymbra by supercritical carbon dioxide extraction: chemical composition and biological activity. AU - Piras,Alessandra, AU - Cocco,Viviana, AU - Falconieri,Danilo, AU - Porcedda,Silvia, AU - Marongiu,Bruno, AU - Maxia,Andrea, AU - Frau,Maria Assunta, AU - Gonçalves,Maria J, AU - Cavaleiro,Carlos, AU - Salgueiro,Ligia, PY - 2011/12/15/entrez PY - 2011/12/15/pubmed PY - 2012/3/1/medline SP - 1523 EP - 6 JF - Natural product communications JO - Nat Prod Commun VL - 6 IS - 10 N2 - Satureja thymbra L. is well known in Italy by the popular name of "Santoreggia sarda". It grows only in Sardinia and nowadays it is restricted to the slope of the Colle San Michele in Cagliari. The composition of the aromatic extracts obtained by supercritical CO2 and by hydrodistillation and their antifungal activity is reported. The collected extracts were analyzed by GC-FID and GC-MS methods. No significant differences were observed in the composition of the volatile extracts depending on the extraction method. The results showed the presence of thymol, gamma-terpinene, beta-caryophyllene, p-cymene, carvacrol and borneol as main components. The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida albicans, C. tropicalis, C. krusei, C. guillermondii, C. parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, T. mentagrophytes, T. mentagrophytes var. interdigitale, Trichophyton rubrum, T. verrucosum, Microsporum canis, M. gypseum, Epidermophyton floccosum, Aspergillus niger, A. fumigatus and A. flavus. The volatile extracts revealed a wide-spectrum antifungal activity. They were fungicidal and similarly potent against yeasts, dermatophyte and Aspergillus stains, with MICs ranging from 0.16 to 0.32 pL x mL(-1). SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/22164799/Isolation_of_the_volatile_oil_from_Satureja_thymbra_by_supercritical_carbon_dioxide_extraction:_chemical_composition_and_biological_activity_ DB - PRIME DP - Unbound Medicine ER -