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Chemical composition and biological activity of the volatile extracts of Achillea millefolium.
Nat Prod Commun. 2011 Oct; 6(10):1527-30.NP

Abstract

In this study, flowering aerial parts of wild Achillea millefolium growing on the Mediterranean coast (Sardinia Island, Italy) and on the Atlantic coast (Portugal- Serra de Montemuro) were used as a matrix for supercritical extraction of volatile oil with CO2 (SFE). The collected extracts were analyzed by GC-FID and GC-MS methods and their composition were compared with that of the essential oil isolated by hydrodistillation. A strong chemical variability in essential oils depending on the origin of the samples was observed. The results showed the presence of two type oils. The Italian volatile extracts (SFE and essential oil) are predominantly composed by alpha-asarone (25.6-33.3%, in the SFE extract and in the HD oil, respectively), beta-bisabolene (27.3-16.6%) and alpha-pinene (10.0-17.0%); whereas the main components of the Portuguese extracts are trans-thujone (31.4-29.0%), trans-crhysanthenyl acetate (19.8-15.8%) and beta-pinene (1.2-11.1%). The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida albicans, C. tropicalis, C. krusei, C. guillermondii, C. parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, T. mentagrophytes, T. mentagrophytes var. interdigitale, T. verrucosum, Microsporum canis, M. gypseum, Epidermophyton floccosum, Aspergillus niger, A. fumigatus and A. flavus. The oils showed the highest activity against dermatophyte strains, with MIC values ranging from 0.32-1.25 microL mL(-1).

Authors+Show Affiliations

Falconieri D
Dipartimento di Scienze Chimiche, Università degli Studi di Cagliari, Cittadella Universitaria di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy.
Piras A
No affiliation info available
Porcedda S
No affiliation info available
Marongiu B
No affiliation info available
Gonçalves MJ
No affiliation info available
Cabral C
No affiliation info available
Cavaleiro C
No affiliation info available
Salgueiro L
No affiliation info available

MeSH

AchilleaOils, VolatilePlant Extracts

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22164800

Citation

Falconieri, Danilo, et al. "Chemical Composition and Biological Activity of the Volatile Extracts of Achillea Millefolium." Natural Product Communications, vol. 6, no. 10, 2011, pp. 1527-30.
Falconieri D, Piras A, Porcedda S, et al. Chemical composition and biological activity of the volatile extracts of Achillea millefolium. Nat Prod Commun. 2011;6(10):1527-30.
Falconieri, D., Piras, A., Porcedda, S., Marongiu, B., Gonçalves, M. J., Cabral, C., Cavaleiro, C., & Salgueiro, L. (2011). Chemical composition and biological activity of the volatile extracts of Achillea millefolium. Natural Product Communications, 6(10), 1527-30.
Falconieri D, et al. Chemical Composition and Biological Activity of the Volatile Extracts of Achillea Millefolium. Nat Prod Commun. 2011;6(10):1527-30. PubMed PMID: 22164800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and biological activity of the volatile extracts of Achillea millefolium. AU - Falconieri,Danilo, AU - Piras,Alessandra, AU - Porcedda,Silvia, AU - Marongiu,Bruno, AU - Gonçalves,Maria J, AU - Cabral,Célia, AU - Cavaleiro,Carlos, AU - Salgueiro,Ligia, PY - 2011/12/15/entrez PY - 2011/12/15/pubmed PY - 2012/3/1/medline SP - 1527 EP - 30 JF - Natural product communications JO - Nat Prod Commun VL - 6 IS - 10 N2 - In this study, flowering aerial parts of wild Achillea millefolium growing on the Mediterranean coast (Sardinia Island, Italy) and on the Atlantic coast (Portugal- Serra de Montemuro) were used as a matrix for supercritical extraction of volatile oil with CO2 (SFE). The collected extracts were analyzed by GC-FID and GC-MS methods and their composition were compared with that of the essential oil isolated by hydrodistillation. A strong chemical variability in essential oils depending on the origin of the samples was observed. The results showed the presence of two type oils. The Italian volatile extracts (SFE and essential oil) are predominantly composed by alpha-asarone (25.6-33.3%, in the SFE extract and in the HD oil, respectively), beta-bisabolene (27.3-16.6%) and alpha-pinene (10.0-17.0%); whereas the main components of the Portuguese extracts are trans-thujone (31.4-29.0%), trans-crhysanthenyl acetate (19.8-15.8%) and beta-pinene (1.2-11.1%). The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida albicans, C. tropicalis, C. krusei, C. guillermondii, C. parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, T. mentagrophytes, T. mentagrophytes var. interdigitale, T. verrucosum, Microsporum canis, M. gypseum, Epidermophyton floccosum, Aspergillus niger, A. fumigatus and A. flavus. The oils showed the highest activity against dermatophyte strains, with MIC values ranging from 0.32-1.25 microL mL(-1). SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/22164800/Chemical_composition_and_biological_activity_of_the_volatile_extracts_of_Achillea_millefolium_ DB - PRIME DP - Unbound Medicine ER -