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Prevalence of sensitivity to cockroach allergens and IgE cross-reactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma.
Chin Med J (Engl). 2010 Dec; 123(24):3540-4.CM

Abstract

BACKGROUND

Cockroaches are an important indoor allergen source causing allergic rhinitis and asthma. The aim of this study was to investigate the cockroach prevalence in mainland of China and the cross-reactivity of IgE between cockroach and house dust mite allergen in Chinese patients.

METHODS

The cockroach sensitization pattern was based on a skin prick test (SPT) obtained from a national multicenter prevalence study, in which 6304 patients from 25 allergy centers across China participated. Factors, including different regions of China, age, gender and the correlations between the American and German cockroaches and house dust mite Der p were investigated. Eighteen out of 1236 clinical sera from south China were selected to perform the cross-inhibition assay between house dust mites and cockroaches.

RESULTS

Totally 25.7% of patients were SPT positive to the American cockroach (Periplaneta Americana, Per a) and 18.7% SPT positive to the German cockroach (Blattella germanica, Bla g). The prevalence of positive cockroach SPT was higher in southern than in northern China, higher in adults than in children, and higher in males than in females. Patients had relatively low levels of cockroach SPT reactions, mainly class 1 or 2. Of the SPT positive cockroach patients, 88% were also SPT positive to house dust mite (Dermatophagoides pteronyssinus, Der p). An IgE cross-inhibition study confirmed that Der p sensitization could cause false positive SPT reactions against cockroach.

CONCLUSIONS

A relatively high prevalence of cockroach sensitivity was found in mainland of China. However, a cross-inhibition study showed that only a small number of patients appear to have Bla g and/or Per a as primary sensitizing source. The importance of cockroaches as a risk factor for sensitization and triggers of allergic symptoms in mainland of China needs to be further investigated.

Authors+Show Affiliations

State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong 510120, China. baoqingsun@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22166627

Citation

Sun, Bao-Qing, et al. "Prevalence of Sensitivity to Cockroach Allergens and IgE Cross-reactivity Between Cockroach and House Dust Mite Allergens in Chinese Patients With Allergic Rhinitis and Asthma." Chinese Medical Journal, vol. 123, no. 24, 2010, pp. 3540-4.
Sun BQ, Lai XX, Gjesing B, et al. Prevalence of sensitivity to cockroach allergens and IgE cross-reactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma. Chin Med J. 2010;123(24):3540-4.
Sun, B. Q., Lai, X. X., Gjesing, B., Spangfort, M. D., & Zhong, N. S. (2010). Prevalence of sensitivity to cockroach allergens and IgE cross-reactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma. Chinese Medical Journal, 123(24), 3540-4.
Sun BQ, et al. Prevalence of Sensitivity to Cockroach Allergens and IgE Cross-reactivity Between Cockroach and House Dust Mite Allergens in Chinese Patients With Allergic Rhinitis and Asthma. Chin Med J. 2010;123(24):3540-4. PubMed PMID: 22166627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of sensitivity to cockroach allergens and IgE cross-reactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma. AU - Sun,Bao-Qing, AU - Lai,Xu-Xin, AU - Gjesing,Birgitte, AU - Spangfort,Michael Dho, AU - Zhong,Nan-Shan, PY - 2011/12/15/entrez PY - 2011/12/15/pubmed PY - 2012/4/26/medline SP - 3540 EP - 4 JF - Chinese medical journal JO - Chin. Med. J. VL - 123 IS - 24 N2 - BACKGROUND: Cockroaches are an important indoor allergen source causing allergic rhinitis and asthma. The aim of this study was to investigate the cockroach prevalence in mainland of China and the cross-reactivity of IgE between cockroach and house dust mite allergen in Chinese patients. METHODS: The cockroach sensitization pattern was based on a skin prick test (SPT) obtained from a national multicenter prevalence study, in which 6304 patients from 25 allergy centers across China participated. Factors, including different regions of China, age, gender and the correlations between the American and German cockroaches and house dust mite Der p were investigated. Eighteen out of 1236 clinical sera from south China were selected to perform the cross-inhibition assay between house dust mites and cockroaches. RESULTS: Totally 25.7% of patients were SPT positive to the American cockroach (Periplaneta Americana, Per a) and 18.7% SPT positive to the German cockroach (Blattella germanica, Bla g). The prevalence of positive cockroach SPT was higher in southern than in northern China, higher in adults than in children, and higher in males than in females. Patients had relatively low levels of cockroach SPT reactions, mainly class 1 or 2. Of the SPT positive cockroach patients, 88% were also SPT positive to house dust mite (Dermatophagoides pteronyssinus, Der p). An IgE cross-inhibition study confirmed that Der p sensitization could cause false positive SPT reactions against cockroach. CONCLUSIONS: A relatively high prevalence of cockroach sensitivity was found in mainland of China. However, a cross-inhibition study showed that only a small number of patients appear to have Bla g and/or Per a as primary sensitizing source. The importance of cockroaches as a risk factor for sensitization and triggers of allergic symptoms in mainland of China needs to be further investigated. SN - 2542-5641 UR - https://www.unboundmedicine.com/medline/citation/22166627/Prevalence_of_sensitivity_to_cockroach_allergens_and_IgE_cross_reactivity_between_cockroach_and_house_dust_mite_allergens_in_Chinese_patients_with_allergic_rhinitis_and_asthma_ L2 - http://Insights.ovid.com/pubmed?pmid=22166627 DB - PRIME DP - Unbound Medicine ER -