Tags

Type your tag names separated by a space and hit enter

Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis.
Food Chem Toxicol. 2012 Mar; 50(3-4):719-25.FC

Abstract

The aim of this study was to investigate the protective effect of quercetin (QE) on oxidative stress, apoptosis, and cell proliferation in the rat testis after streptozotocin (STZ)-induced diabetes. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). The rats in the QE-treated group were given QE (15 mg/kg) once a day intraperitoneally for 8 weeks starting 3 days prior to STZ injection. At the end of the study, all animals were sacrificed. Testis tissues and blood samples were collected for histopathologic and biochemical analysis. QE treatment significantly decreased the elevated tissue malondialdehyde (MDA) levels and increased the reduced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzyme activities in testis tissues samples. The QE-treated rats in the diabetic group showed an improved histologic appearance and serum testosterone levels. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling (TUNEL) and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of QE-treated rats in the diabetic group. These results suggest that administration of QE is a potentially beneficial agent to reduce testicular damage in diabetic rats by decreasing oxidative stress.

Authors+Show Affiliations

Department of Histology and Embryology, Faculty of Medicine, University of Trakya, Edirne, Turkey. mkanter65@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22166789

Citation

Kanter, Mehmet, et al. "Protective Effects of Quercetin Against Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rat Testis." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 50, no. 3-4, 2012, pp. 719-25.
Kanter M, Aktas C, Erboga M. Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis. Food Chem Toxicol. 2012;50(3-4):719-25.
Kanter, M., Aktas, C., & Erboga, M. (2012). Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 50(3-4), 719-25. https://doi.org/10.1016/j.fct.2011.11.051
Kanter M, Aktas C, Erboga M. Protective Effects of Quercetin Against Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rat Testis. Food Chem Toxicol. 2012;50(3-4):719-25. PubMed PMID: 22166789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis. AU - Kanter,Mehmet, AU - Aktas,Cevat, AU - Erboga,Mustafa, Y1 - 2011/12/06/ PY - 2011/10/24/received PY - 2011/11/24/revised PY - 2011/11/27/accepted PY - 2011/12/15/entrez PY - 2011/12/15/pubmed PY - 2012/7/17/medline SP - 719 EP - 25 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 50 IS - 3-4 N2 - The aim of this study was to investigate the protective effect of quercetin (QE) on oxidative stress, apoptosis, and cell proliferation in the rat testis after streptozotocin (STZ)-induced diabetes. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). The rats in the QE-treated group were given QE (15 mg/kg) once a day intraperitoneally for 8 weeks starting 3 days prior to STZ injection. At the end of the study, all animals were sacrificed. Testis tissues and blood samples were collected for histopathologic and biochemical analysis. QE treatment significantly decreased the elevated tissue malondialdehyde (MDA) levels and increased the reduced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzyme activities in testis tissues samples. The QE-treated rats in the diabetic group showed an improved histologic appearance and serum testosterone levels. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling (TUNEL) and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of QE-treated rats in the diabetic group. These results suggest that administration of QE is a potentially beneficial agent to reduce testicular damage in diabetic rats by decreasing oxidative stress. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/22166789/Protective_effects_of_quercetin_against_apoptosis_and_oxidative_stress_in_streptozotocin_induced_diabetic_rat_testis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(11)00649-1 DB - PRIME DP - Unbound Medicine ER -