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Repeated measurements of serum carotenoid, retinol and tocopherol levels in relation to colorectal cancer risk in the Women's Health Initiative.
Eur J Clin Nutr 2012; 66(5):549-54EJ

Abstract

BACKGROUND/OBJECTIVE

Previous cohort studies examining the association of serum antioxidant levels and risk of colorectal cancer have used a single (baseline) measurement only. In the present study, we assessed the association of serum levels of eight antioxidant nutrients in relation to risk of colorectal cancer, using repeated measurements.

SUBJECTS/METHODS

Data on a subsample of women in the Women's Health Initiative with repeated measurements of serum retinol, α-carotene, β-carotene, β-cryptoxanthin, lutein+zeaxanthin, lycopene, α-tocopherol and γ-tocopherol during follow-up were included in the analysis. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CIs).

RESULTS

Among 5477 women with baseline serum antioxidant values, 88 incident cases of colorectal cancer were identified over a median follow-up time of 12 years. Serum antioxidants measured at baseline generally showed no association with risk of colorectal cancer, although serum β-carotene at baseline showed a non-significant inverse association with colon cancer alone. Furthermore, using the repeated measurements of β-carotene, the average of all measurements was inversely associated with risk of both colorectal and colon cancer: HRs for highest vs lowest tertile 0.54, 95% CI 0.31-0.96, and 0.47, 95% CI 0.25-0.88, respectively. No associations were seen with other antioxidant nutrients in the repeated measure analyses.

CONCLUSIONS

In this study, baseline levels of antioxidant nutrients were not associated with risk of colorectal or colon cancer; however, using repeated measures, a relatively high serum level of β-carotene (average of all measurements) was inversely associated with risk of colon and colorectal cancer in postmenopausal women.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Geoffrey.kabat@einstein.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22166899

Citation

Kabat, G C., et al. "Repeated Measurements of Serum Carotenoid, Retinol and Tocopherol Levels in Relation to Colorectal Cancer Risk in the Women's Health Initiative." European Journal of Clinical Nutrition, vol. 66, no. 5, 2012, pp. 549-54.
Kabat GC, Kim MY, Sarto GE, et al. Repeated measurements of serum carotenoid, retinol and tocopherol levels in relation to colorectal cancer risk in the Women's Health Initiative. Eur J Clin Nutr. 2012;66(5):549-54.
Kabat, G. C., Kim, M. Y., Sarto, G. E., Shikany, J. M., & Rohan, T. E. (2012). Repeated measurements of serum carotenoid, retinol and tocopherol levels in relation to colorectal cancer risk in the Women's Health Initiative. European Journal of Clinical Nutrition, 66(5), pp. 549-54. doi:10.1038/ejcn.2011.207.
Kabat GC, et al. Repeated Measurements of Serum Carotenoid, Retinol and Tocopherol Levels in Relation to Colorectal Cancer Risk in the Women's Health Initiative. Eur J Clin Nutr. 2012;66(5):549-54. PubMed PMID: 22166899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated measurements of serum carotenoid, retinol and tocopherol levels in relation to colorectal cancer risk in the Women's Health Initiative. AU - Kabat,G C, AU - Kim,M Y, AU - Sarto,G E, AU - Shikany,J M, AU - Rohan,T E, Y1 - 2011/12/14/ PY - 2011/12/15/entrez PY - 2011/12/15/pubmed PY - 2012/8/17/medline SP - 549 EP - 54 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 66 IS - 5 N2 - BACKGROUND/OBJECTIVE: Previous cohort studies examining the association of serum antioxidant levels and risk of colorectal cancer have used a single (baseline) measurement only. In the present study, we assessed the association of serum levels of eight antioxidant nutrients in relation to risk of colorectal cancer, using repeated measurements. SUBJECTS/METHODS: Data on a subsample of women in the Women's Health Initiative with repeated measurements of serum retinol, α-carotene, β-carotene, β-cryptoxanthin, lutein+zeaxanthin, lycopene, α-tocopherol and γ-tocopherol during follow-up were included in the analysis. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CIs). RESULTS: Among 5477 women with baseline serum antioxidant values, 88 incident cases of colorectal cancer were identified over a median follow-up time of 12 years. Serum antioxidants measured at baseline generally showed no association with risk of colorectal cancer, although serum β-carotene at baseline showed a non-significant inverse association with colon cancer alone. Furthermore, using the repeated measurements of β-carotene, the average of all measurements was inversely associated with risk of both colorectal and colon cancer: HRs for highest vs lowest tertile 0.54, 95% CI 0.31-0.96, and 0.47, 95% CI 0.25-0.88, respectively. No associations were seen with other antioxidant nutrients in the repeated measure analyses. CONCLUSIONS: In this study, baseline levels of antioxidant nutrients were not associated with risk of colorectal or colon cancer; however, using repeated measures, a relatively high serum level of β-carotene (average of all measurements) was inversely associated with risk of colon and colorectal cancer in postmenopausal women. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/22166899/Repeated_measurements_of_serum_carotenoid_retinol_and_tocopherol_levels_in_relation_to_colorectal_cancer_risk_in_the_Women's_Health_Initiative_ L2 - http://dx.doi.org/10.1038/ejcn.2011.207 DB - PRIME DP - Unbound Medicine ER -