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Tumor location is an independent prognostic factor in head and neck Merkel cell carcinoma.
Otolaryngol Head Neck Surg. 2012 Mar; 146(3):403-8.OH

Abstract

OBJECTIVE

Explore the relationship between tumor location and prognosis among patients with Merkel cell carcinoma (MCC) of the head and neck.

STUDY DESIGN

Retrospective analysis of large population database.

SETTING

Surveillance Epidemiology and End Results (SEER) database/multiple settings.

SUBJECTS AND METHODS

Using the SEER database, the authors identified patients with MCC of the head and neck. They compared clinicopathologic characteristics and disease-specific survival (DSS) between patients with head and neck MCC at different anatomic subsites. DSS was estimated by the Kaplan-Meier method, and a multivariable regression model was constructed so that independent predictors of DSS could be determined.

RESULTS

Of the 2104 patients identified, 61.0% were men. The mean age at diagnosis was 77.5 years. Tumors were most commonly located on the face (61.1%). Scalp tumors were significantly larger (10.4% >5 cm, P = .0001) and more likely to present with distant metastasis (8.7%, P = .07) than other head and neck tumors. Lip tumors had the highest rate of invasion into bone, cartilage, and muscle (13.7%, P = .012), and ear tumors had the highest rate of nodal metastasis (63.2%, P = .011). Patients with scalp/neck and lip primary sites had significantly worse survival on univariable analysis (P = .0054 and P = .0007, respectively); however, the lip was the only site associated with worse survival on multivariable analysis (hazard ratio = 1.8, P = .005).

CONCLUSIONS

This study is the first to report lip location as an independent prognostic factor in head and neck MCC. More aggressive treatment of patients with MCC of the lip may be warranted to improve outcomes.

Authors+Show Affiliations

College of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425-5500, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22166964

Citation

Smith, Valerie A., et al. "Tumor Location Is an Independent Prognostic Factor in Head and Neck Merkel Cell Carcinoma." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 146, no. 3, 2012, pp. 403-8.
Smith VA, MaDan OP, Lentsch EJ. Tumor location is an independent prognostic factor in head and neck Merkel cell carcinoma. Otolaryngol Head Neck Surg. 2012;146(3):403-8.
Smith, V. A., MaDan, O. P., & Lentsch, E. J. (2012). Tumor location is an independent prognostic factor in head and neck Merkel cell carcinoma. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 146(3), 403-8. https://doi.org/10.1177/0194599811431789
Smith VA, MaDan OP, Lentsch EJ. Tumor Location Is an Independent Prognostic Factor in Head and Neck Merkel Cell Carcinoma. Otolaryngol Head Neck Surg. 2012;146(3):403-8. PubMed PMID: 22166964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumor location is an independent prognostic factor in head and neck Merkel cell carcinoma. AU - Smith,Valerie A, AU - MaDan,Olivia P, AU - Lentsch,Eric J, Y1 - 2011/12/13/ PY - 2011/12/15/entrez PY - 2011/12/15/pubmed PY - 2012/4/24/medline SP - 403 EP - 8 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 146 IS - 3 N2 - OBJECTIVE: Explore the relationship between tumor location and prognosis among patients with Merkel cell carcinoma (MCC) of the head and neck. STUDY DESIGN: Retrospective analysis of large population database. SETTING: Surveillance Epidemiology and End Results (SEER) database/multiple settings. SUBJECTS AND METHODS: Using the SEER database, the authors identified patients with MCC of the head and neck. They compared clinicopathologic characteristics and disease-specific survival (DSS) between patients with head and neck MCC at different anatomic subsites. DSS was estimated by the Kaplan-Meier method, and a multivariable regression model was constructed so that independent predictors of DSS could be determined. RESULTS: Of the 2104 patients identified, 61.0% were men. The mean age at diagnosis was 77.5 years. Tumors were most commonly located on the face (61.1%). Scalp tumors were significantly larger (10.4% >5 cm, P = .0001) and more likely to present with distant metastasis (8.7%, P = .07) than other head and neck tumors. Lip tumors had the highest rate of invasion into bone, cartilage, and muscle (13.7%, P = .012), and ear tumors had the highest rate of nodal metastasis (63.2%, P = .011). Patients with scalp/neck and lip primary sites had significantly worse survival on univariable analysis (P = .0054 and P = .0007, respectively); however, the lip was the only site associated with worse survival on multivariable analysis (hazard ratio = 1.8, P = .005). CONCLUSIONS: This study is the first to report lip location as an independent prognostic factor in head and neck MCC. More aggressive treatment of patients with MCC of the lip may be warranted to improve outcomes. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/22166964/Tumor_location_is_an_independent_prognostic_factor_in_head_and_neck_Merkel_cell_carcinoma_ L2 - https://journals.sagepub.com/doi/10.1177/0194599811431789?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -