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Application of magnifying narrow-band imaging endoscopy for diagnosis of early gastric cancer and precancerous lesion.
BMC Gastroenterol 2011; 11:135BG

Abstract

BACKGROUND

Gastric carcinoma is the second commonest cause of cancer deaths worldwide. Early detection and diagnosis of gastric cancer in the stomach is important for improving the prognosis of gastric cancer. This retrospective study was designed to investigate the value of magnifying narrow-band imaging (NBI) in the diagnosis of precancerous lesions and early gastric cancer.

METHODS

This study included 122 patients who were diagnosed with early gastric cancer or precancerous gastric lesions by endoscopy. The patients underwent an examination with conventional endoscopy, magnifying NBI, and magnifying chromoendoscopy. Images resolution was evaluated, and the morphology, pit patterns and blood capillary forms of lesions were analyzed. The presence of gastric carcinoma and high grade intraepithelial neoplasia in the biopsy samples was considered as a positive pathological result, which is used to assess accuracy of endoscopic diagnosis.

RESULTS

For image resolution, magnifying NBI and magnifying chromoendoscopy were significantly superior to magnifying conventional endoscopy in morphology, pit pattern and blood capillary form (P < 0.01), and magnifying NBI was significantly superior to magnifying chromoendoscopy in blood capillary form (P < 0.01). IV, V(1), and VI type of gastric pit pattern were detected in 14 cases, 43 cases, and 17 cases in patients with high grade intraepithelial neoplasia, respectively. V(1) and VI type of gastric pit pattern were detected in 9 cases and 39 cases in patients with early gastric cancer, respectively. The presence of irregular minute vessels and variation in the caliber of vessels was found in 109 cases. The accuracy, sensitivity, specificity, false positive rate and false negative rate for diagnosis of early gastric cancer and precancerous gastric lesions were 68.9%, 95.1%, 63.1%, 24.5%, and 32.4% for conventional endoscopy, 93.6%, 92.7%, 94.5%, 5.7%, and 6.9% for magnifying NBI, and 91.3%, 88.6%, 93.2%, 13.2%, and 21.48% for magnifying chromoendoscopy, respectively.

CONCLUSIONS

This study demonstrates that magnifying NBI is superior to conventional endoscopy in the diagnosis of early gastric cancer and precancerous gastric lesions, and can be used for screening early malignancies of the stomach.

Authors+Show Affiliations

Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Dalian 0086-116011, Liaoning Province, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22168239

Citation

Zhang, Jing, et al. "Application of Magnifying Narrow-band Imaging Endoscopy for Diagnosis of Early Gastric Cancer and Precancerous Lesion." BMC Gastroenterology, vol. 11, 2011, p. 135.
Zhang J, Guo SB, Duan ZJ. Application of magnifying narrow-band imaging endoscopy for diagnosis of early gastric cancer and precancerous lesion. BMC Gastroenterol. 2011;11:135.
Zhang, J., Guo, S. B., & Duan, Z. J. (2011). Application of magnifying narrow-band imaging endoscopy for diagnosis of early gastric cancer and precancerous lesion. BMC Gastroenterology, 11, p. 135. doi:10.1186/1471-230X-11-135.
Zhang J, Guo SB, Duan ZJ. Application of Magnifying Narrow-band Imaging Endoscopy for Diagnosis of Early Gastric Cancer and Precancerous Lesion. BMC Gastroenterol. 2011 Dec 14;11:135. PubMed PMID: 22168239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Application of magnifying narrow-band imaging endoscopy for diagnosis of early gastric cancer and precancerous lesion. AU - Zhang,Jing, AU - Guo,Shi-Bin, AU - Duan,Zhi-Jun, Y1 - 2011/12/14/ PY - 2011/08/29/received PY - 2011/12/14/accepted PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2012/4/20/medline SP - 135 EP - 135 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 11 N2 - BACKGROUND: Gastric carcinoma is the second commonest cause of cancer deaths worldwide. Early detection and diagnosis of gastric cancer in the stomach is important for improving the prognosis of gastric cancer. This retrospective study was designed to investigate the value of magnifying narrow-band imaging (NBI) in the diagnosis of precancerous lesions and early gastric cancer. METHODS: This study included 122 patients who were diagnosed with early gastric cancer or precancerous gastric lesions by endoscopy. The patients underwent an examination with conventional endoscopy, magnifying NBI, and magnifying chromoendoscopy. Images resolution was evaluated, and the morphology, pit patterns and blood capillary forms of lesions were analyzed. The presence of gastric carcinoma and high grade intraepithelial neoplasia in the biopsy samples was considered as a positive pathological result, which is used to assess accuracy of endoscopic diagnosis. RESULTS: For image resolution, magnifying NBI and magnifying chromoendoscopy were significantly superior to magnifying conventional endoscopy in morphology, pit pattern and blood capillary form (P < 0.01), and magnifying NBI was significantly superior to magnifying chromoendoscopy in blood capillary form (P < 0.01). IV, V(1), and VI type of gastric pit pattern were detected in 14 cases, 43 cases, and 17 cases in patients with high grade intraepithelial neoplasia, respectively. V(1) and VI type of gastric pit pattern were detected in 9 cases and 39 cases in patients with early gastric cancer, respectively. The presence of irregular minute vessels and variation in the caliber of vessels was found in 109 cases. The accuracy, sensitivity, specificity, false positive rate and false negative rate for diagnosis of early gastric cancer and precancerous gastric lesions were 68.9%, 95.1%, 63.1%, 24.5%, and 32.4% for conventional endoscopy, 93.6%, 92.7%, 94.5%, 5.7%, and 6.9% for magnifying NBI, and 91.3%, 88.6%, 93.2%, 13.2%, and 21.48% for magnifying chromoendoscopy, respectively. CONCLUSIONS: This study demonstrates that magnifying NBI is superior to conventional endoscopy in the diagnosis of early gastric cancer and precancerous gastric lesions, and can be used for screening early malignancies of the stomach. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/22168239/Application_of_magnifying_narrow_band_imaging_endoscopy_for_diagnosis_of_early_gastric_cancer_and_precancerous_lesion_ L2 - https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-11-135 DB - PRIME DP - Unbound Medicine ER -