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Hydroxyapatite paste Ostim, without elevation of full-thickness flaps, improves alveolar healing stimulating BMP- and VEGF-mediated signal pathways: an experimental study in humans.
Clin Oral Implants Res 2013; 24 Suppl A100:42-8CO

Abstract

OBJECTIVE

Tooth extraction is considered as the starting point of jaw atrophy via osteoclast activity stimulation. The maintenance of dental alveolar bone depends on surgery procedure and use of materials to maintain prior space favoring bone regeneration. Among substitutes used in dentistry to fill bone defects, Ostim-Pastes (Ostim) is a nanocrystalline paste tested for treatment of severe clinical conditions. This research first investigated the effect of Ostim on alveolar healing, comparing in the same healthy subjects, an Ostim-filled socket with a not-filled one. Moreover, it also proposed a new surgical protocol for the post-extractive socket treatment using the graft materials without elevation of full-thickness flaps.

MATERIAL AND METHODS

Fourteen patients were enrolled to bilateral maxillary or mandibular extraction that was performed without elevation of full-thickness flaps. In each patient, one socket was filled using Ostim, and the other one was allowed to undergo natural healing. No suture was carried out. Clinical and biologic parameters were screened at 1, 7, and 14 days.

RESULTS

Obtained results evidenced that nanocrystalline hydroxyapatite supports bone regeneration, increasing the synthesis of pro-osteogenic factors as bone morphogenetics protein (BMP)-4, BMP-7, alkaline phosphatase, and osteocalcin. Moreover, filling post-extractive socket with nanocrystalline hydroxyapatite paste leads to a complete epithelialization already at 7 days after extraction, despite the fact that the teeth were extracted without elevation of full-thickness flaps . The improved epithelialization is mediated by increased vascular endothelial growth factor (VEGF) expression. No significant change was observed in inflammatory parameters, with exception of an early and transient IL-1β induction, that could trigger and improve alveolar healing.

CONCLUSIONS

Clinical and biomolecular observations of this explorative study evidenced that nanocrystalline hydroxyapatite improves alveolar socket healing, increasing angiogenesis, epithelialization, and osteogenesis, also in absence of elevation of full-thickness flaps.

Authors+Show Affiliations

Department of Experimental Medicine and Oncology, University of Turin, Turin, Italy.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22168539

Citation

Canuto, R A., et al. "Hydroxyapatite Paste Ostim, Without Elevation of Full-thickness Flaps, Improves Alveolar Healing Stimulating BMP- and VEGF-mediated Signal Pathways: an Experimental Study in Humans." Clinical Oral Implants Research, vol. 24 Suppl A100, 2013, pp. 42-8.
Canuto RA, Pol R, Martinasso G, et al. Hydroxyapatite paste Ostim, without elevation of full-thickness flaps, improves alveolar healing stimulating BMP- and VEGF-mediated signal pathways: an experimental study in humans. Clin Oral Implants Res. 2013;24 Suppl A100:42-8.
Canuto, R. A., Pol, R., Martinasso, G., Muzio, G., Gallesio, G., & Mozzati, M. (2013). Hydroxyapatite paste Ostim, without elevation of full-thickness flaps, improves alveolar healing stimulating BMP- and VEGF-mediated signal pathways: an experimental study in humans. Clinical Oral Implants Research, 24 Suppl A100, pp. 42-8. doi:10.1111/j.1600-0501.2011.02363.x.
Canuto RA, et al. Hydroxyapatite Paste Ostim, Without Elevation of Full-thickness Flaps, Improves Alveolar Healing Stimulating BMP- and VEGF-mediated Signal Pathways: an Experimental Study in Humans. Clin Oral Implants Res. 2013;24 Suppl A100:42-8. PubMed PMID: 22168539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroxyapatite paste Ostim, without elevation of full-thickness flaps, improves alveolar healing stimulating BMP- and VEGF-mediated signal pathways: an experimental study in humans. AU - Canuto,R A, AU - Pol,R, AU - Martinasso,G, AU - Muzio,G, AU - Gallesio,G, AU - Mozzati,M, Y1 - 2011/12/15/ PY - 2011/10/02/accepted PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2014/9/3/medline KW - bone morphogenetics protein KW - bone repair KW - dental restorative material KW - hydroxyapatite paste Ostim® KW - interleukin KW - mucosa KW - vascular endothelial growth factor SP - 42 EP - 8 JF - Clinical oral implants research JO - Clin Oral Implants Res VL - 24 Suppl A100 N2 - OBJECTIVE: Tooth extraction is considered as the starting point of jaw atrophy via osteoclast activity stimulation. The maintenance of dental alveolar bone depends on surgery procedure and use of materials to maintain prior space favoring bone regeneration. Among substitutes used in dentistry to fill bone defects, Ostim-Pastes (Ostim) is a nanocrystalline paste tested for treatment of severe clinical conditions. This research first investigated the effect of Ostim on alveolar healing, comparing in the same healthy subjects, an Ostim-filled socket with a not-filled one. Moreover, it also proposed a new surgical protocol for the post-extractive socket treatment using the graft materials without elevation of full-thickness flaps. MATERIAL AND METHODS: Fourteen patients were enrolled to bilateral maxillary or mandibular extraction that was performed without elevation of full-thickness flaps. In each patient, one socket was filled using Ostim, and the other one was allowed to undergo natural healing. No suture was carried out. Clinical and biologic parameters were screened at 1, 7, and 14 days. RESULTS: Obtained results evidenced that nanocrystalline hydroxyapatite supports bone regeneration, increasing the synthesis of pro-osteogenic factors as bone morphogenetics protein (BMP)-4, BMP-7, alkaline phosphatase, and osteocalcin. Moreover, filling post-extractive socket with nanocrystalline hydroxyapatite paste leads to a complete epithelialization already at 7 days after extraction, despite the fact that the teeth were extracted without elevation of full-thickness flaps . The improved epithelialization is mediated by increased vascular endothelial growth factor (VEGF) expression. No significant change was observed in inflammatory parameters, with exception of an early and transient IL-1β induction, that could trigger and improve alveolar healing. CONCLUSIONS: Clinical and biomolecular observations of this explorative study evidenced that nanocrystalline hydroxyapatite improves alveolar socket healing, increasing angiogenesis, epithelialization, and osteogenesis, also in absence of elevation of full-thickness flaps. SN - 1600-0501 UR - https://www.unboundmedicine.com/medline/citation/22168539/Hydroxyapatite_paste_Ostim_without_elevation_of_full_thickness_flaps_improves_alveolar_healing_stimulating_BMP__and_VEGF_mediated_signal_pathways:_an_experimental_study_in_humans_ L2 - https://doi.org/10.1111/j.1600-0501.2011.02363.x DB - PRIME DP - Unbound Medicine ER -