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Advanced electrocardiographic parameters change with severity of mitral regurgitation in Cavalier King Charles Spaniels in sinus rhythm.
J Vet Intern Med. 2012 Jan-Feb; 26(1):93-100.JV

Abstract

BACKGROUND

Multiple advanced resting ECG (A-ECG) techniques have improved the diagnostic or prognostic value of ECG in detecting human cardiac diseases even before onset of clinical signs or changes in conventional ECG.

OBJECTIVE

To determine which A-ECG parameters, derived from 12-lead A-ECG recordings, change with severity of mitral regurgitation (MR) caused by myxomatous mitral valve disease (MMVD) in Cavalier King Charles Spaniels (CKCSs) in sinus rhythm.

ANIMALS

Seventy-six privately owned CKCSs.

METHODS

Dogs were prospectively divided into 5 groups according to the degree of MR (estimated by color Doppler mapping as the percentage of the left atrial area affected by the MR jet) and presence of clinical signs. High fidelity approximately 5-minute 12-lead ECG recordings were evaluated using custom software to calculate multiple conventional and A-ECG parameters.

RESULTS

Nineteen of 76 ECG parameters were significantly different (P < .05) across the 5 dog groups. A 4-parameter model that incorporated results from 1 parameter of heart rate variability, 2 parameters of QT variability, and 1 parameter of QRS amplitude was identified that explained 82.4% of the variance with a correlation coefficient (R) of 0.60 (P < .01). When age or murmur grade was included in the statistical model the prediction value further increased the R to 0.74 and 0.85 (P < .01), respectively.

CONCLUSION

In CKCSs with sinus rhythm, 4 selected A-ECG parameters further improve prediction of MR jet severity beyond age and murmur grade, although the predictive increment in this study probably is not sufficient to warrant utilization in clinical veterinary practice.

Authors+Show Affiliations

Institute of Physiology, Medical Faculty, Ljubljana, Slovenia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22168834

Citation

Spiljak Pakkanen, M, et al. "Advanced Electrocardiographic Parameters Change With Severity of Mitral Regurgitation in Cavalier King Charles Spaniels in Sinus Rhythm." Journal of Veterinary Internal Medicine, vol. 26, no. 1, 2012, pp. 93-100.
Spiljak Pakkanen M, Domanjko Petrič A, Olsen LH, et al. Advanced electrocardiographic parameters change with severity of mitral regurgitation in Cavalier King Charles Spaniels in sinus rhythm. J Vet Intern Med. 2012;26(1):93-100.
Spiljak Pakkanen, M., Domanjko Petrič, A., Olsen, L. H., Stepančič, A., Schlegel, T. T., Falk, T., Rasmussen, C. E., & Starc, V. (2012). Advanced electrocardiographic parameters change with severity of mitral regurgitation in Cavalier King Charles Spaniels in sinus rhythm. Journal of Veterinary Internal Medicine, 26(1), 93-100. https://doi.org/10.1111/j.1939-1676.2011.00845.x
Spiljak Pakkanen M, et al. Advanced Electrocardiographic Parameters Change With Severity of Mitral Regurgitation in Cavalier King Charles Spaniels in Sinus Rhythm. J Vet Intern Med. 2012 Jan-Feb;26(1):93-100. PubMed PMID: 22168834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advanced electrocardiographic parameters change with severity of mitral regurgitation in Cavalier King Charles Spaniels in sinus rhythm. AU - Spiljak Pakkanen,M, AU - Domanjko Petrič,A, AU - Olsen,L H, AU - Stepančič,A, AU - Schlegel,T T, AU - Falk,T, AU - Rasmussen,C E, AU - Starc,V, Y1 - 2011/12/14/ PY - 2011/03/22/received PY - 2011/08/24/revised PY - 2011/10/26/accepted PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2012/5/18/medline SP - 93 EP - 100 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 26 IS - 1 N2 - BACKGROUND: Multiple advanced resting ECG (A-ECG) techniques have improved the diagnostic or prognostic value of ECG in detecting human cardiac diseases even before onset of clinical signs or changes in conventional ECG. OBJECTIVE: To determine which A-ECG parameters, derived from 12-lead A-ECG recordings, change with severity of mitral regurgitation (MR) caused by myxomatous mitral valve disease (MMVD) in Cavalier King Charles Spaniels (CKCSs) in sinus rhythm. ANIMALS: Seventy-six privately owned CKCSs. METHODS: Dogs were prospectively divided into 5 groups according to the degree of MR (estimated by color Doppler mapping as the percentage of the left atrial area affected by the MR jet) and presence of clinical signs. High fidelity approximately 5-minute 12-lead ECG recordings were evaluated using custom software to calculate multiple conventional and A-ECG parameters. RESULTS: Nineteen of 76 ECG parameters were significantly different (P < .05) across the 5 dog groups. A 4-parameter model that incorporated results from 1 parameter of heart rate variability, 2 parameters of QT variability, and 1 parameter of QRS amplitude was identified that explained 82.4% of the variance with a correlation coefficient (R) of 0.60 (P < .01). When age or murmur grade was included in the statistical model the prediction value further increased the R to 0.74 and 0.85 (P < .01), respectively. CONCLUSION: In CKCSs with sinus rhythm, 4 selected A-ECG parameters further improve prediction of MR jet severity beyond age and murmur grade, although the predictive increment in this study probably is not sufficient to warrant utilization in clinical veterinary practice. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/22168834/Advanced_electrocardiographic_parameters_change_with_severity_of_mitral_regurgitation_in_Cavalier_King_Charles_Spaniels_in_sinus_rhythm_ L2 - https://doi.org/10.1111/j.1939-1676.2011.00845.x DB - PRIME DP - Unbound Medicine ER -