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Usual interstitial pneumonia and nonspecific interstitial pneumonia: correlation between CT findings at the site of biopsy with pathological diagnoses.
Eur J Radiol. 2012 Oct; 81(10):2919-24.EJ

Abstract

OBJECTIVES

The aim of this study was to correlate high-resolution CT (HRCT) findings at the site of biopsy with the whole lung CT and pathologic diagnoses in usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP).

METHODS

The study included 35 patients (25 UIP and 10 NSIP) diagnosed both pathologically and clinically. 81 surgical biopsy specimens (54 UIP, and 27 NSIP) and extracted areas corresponding to biopsy sites on HRCT were analyzed. CT interpretations were compared with pathological diagnoses in both extracted images and the whole lung. Concordant and discordant cases in multiple extracted images were divided and analyzed. Then the whole cases were categorized by including or not at least one UIP diagnosis of extracted images and evaluated.

RESULTS

The diagnoses in extracted sites significantly correlated with pathological diagnoses (p=0.047). There were significant differences in the concordances of extracted images compared with the diagnosis of whole lung and pathology (p=0.008, 0.003, respectively). All 7 cases that were not concordant were diagnosed as radiological UIP with whole lung CT. The cases with at least one UIP diagnosis of extracted CT images were diagnosed as UIP in pathology more frequently (18 in 25) (p=0.007).

CONCLUSIONS

Radiological UIP in whole CT had more frequently discordant diagnoses from multiple extracted images than NSIP. And there were more cases in pathological UIP that included at least one UIP diagnosis of extracted images compared with pathological NSIP.

Authors+Show Affiliations

Department of Radiology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0825, Japan. h-sumikawa@radiol.med.osaka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22169358

Citation

Sumikawa, Hiromitsu, et al. "Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia: Correlation Between CT Findings at the Site of Biopsy With Pathological Diagnoses." European Journal of Radiology, vol. 81, no. 10, 2012, pp. 2919-24.
Sumikawa H, Johkoh T, Fujimoto K, et al. Usual interstitial pneumonia and nonspecific interstitial pneumonia: correlation between CT findings at the site of biopsy with pathological diagnoses. Eur J Radiol. 2012;81(10):2919-24.
Sumikawa, H., Johkoh, T., Fujimoto, K., Ichikado, K., Colby, T. V., Fukuoka, J., Taniguchi, H., Kondoh, Y., Kataoka, K., Yanagawa, M., Koyama, M., Honda, O., & Tomiyama, N. (2012). Usual interstitial pneumonia and nonspecific interstitial pneumonia: correlation between CT findings at the site of biopsy with pathological diagnoses. European Journal of Radiology, 81(10), 2919-24. https://doi.org/10.1016/j.ejrad.2011.11.018
Sumikawa H, et al. Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia: Correlation Between CT Findings at the Site of Biopsy With Pathological Diagnoses. Eur J Radiol. 2012;81(10):2919-24. PubMed PMID: 22169358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usual interstitial pneumonia and nonspecific interstitial pneumonia: correlation between CT findings at the site of biopsy with pathological diagnoses. AU - Sumikawa,Hiromitsu, AU - Johkoh,Takeshi, AU - Fujimoto,Kiminori, AU - Ichikado,Kazuya, AU - Colby,Thomas V, AU - Fukuoka,Junya, AU - Taniguchi,Hiroyuki, AU - Kondoh,Yasuhiro, AU - Kataoka,Kensuke, AU - Yanagawa,Masahiro, AU - Koyama,Mitsuhiro, AU - Honda,Osamu, AU - Tomiyama,Noriyuki, Y1 - 2011/12/12/ PY - 2011/06/20/received PY - 2011/11/11/revised PY - 2011/11/15/accepted PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2013/1/25/medline SP - 2919 EP - 24 JF - European journal of radiology JO - Eur J Radiol VL - 81 IS - 10 N2 - OBJECTIVES: The aim of this study was to correlate high-resolution CT (HRCT) findings at the site of biopsy with the whole lung CT and pathologic diagnoses in usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). METHODS: The study included 35 patients (25 UIP and 10 NSIP) diagnosed both pathologically and clinically. 81 surgical biopsy specimens (54 UIP, and 27 NSIP) and extracted areas corresponding to biopsy sites on HRCT were analyzed. CT interpretations were compared with pathological diagnoses in both extracted images and the whole lung. Concordant and discordant cases in multiple extracted images were divided and analyzed. Then the whole cases were categorized by including or not at least one UIP diagnosis of extracted images and evaluated. RESULTS: The diagnoses in extracted sites significantly correlated with pathological diagnoses (p=0.047). There were significant differences in the concordances of extracted images compared with the diagnosis of whole lung and pathology (p=0.008, 0.003, respectively). All 7 cases that were not concordant were diagnosed as radiological UIP with whole lung CT. The cases with at least one UIP diagnosis of extracted CT images were diagnosed as UIP in pathology more frequently (18 in 25) (p=0.007). CONCLUSIONS: Radiological UIP in whole CT had more frequently discordant diagnoses from multiple extracted images than NSIP. And there were more cases in pathological UIP that included at least one UIP diagnosis of extracted images compared with pathological NSIP. SN - 1872-7727 UR - https://www.unboundmedicine.com/medline/citation/22169358/Usual_interstitial_pneumonia_and_nonspecific_interstitial_pneumonia:_correlation_between_CT_findings_at_the_site_of_biopsy_with_pathological_diagnoses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0720-048X(11)00796-0 DB - PRIME DP - Unbound Medicine ER -