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Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2.
J Pharm Biomed Anal. 2012 Mar 05; 61:122-35.JP

Abstract

The recent global increase in the abuse of 4'-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4'-methyl-N-ethylcathinone (4-MEC) and 4'-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the "legal high" NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.

Authors+Show Affiliations

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22169465

Citation

Khreit, Osama I G., et al. "Synthesis, Full Chemical Characterisation and Development of Validated Methods for the Quantification of the Components Found in the Evolved "legal High" NRG-2." Journal of Pharmaceutical and Biomedical Analysis, vol. 61, 2012, pp. 122-35.
Khreit OI, Irving C, Schmidt E, et al. Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2. J Pharm Biomed Anal. 2012;61:122-35.
Khreit, O. I., Irving, C., Schmidt, E., Parkinson, J. A., Nic Daeid, N., & Sutcliffe, O. B. (2012). Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2. Journal of Pharmaceutical and Biomedical Analysis, 61, 122-35. https://doi.org/10.1016/j.jpba.2011.11.004
Khreit OI, et al. Synthesis, Full Chemical Characterisation and Development of Validated Methods for the Quantification of the Components Found in the Evolved "legal High" NRG-2. J Pharm Biomed Anal. 2012 Mar 5;61:122-35. PubMed PMID: 22169465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2. AU - Khreit,Osama I G, AU - Irving,Craig, AU - Schmidt,Elke, AU - Parkinson,John A, AU - Nic Daeid,Niamh, AU - Sutcliffe,Oliver B, Y1 - 2011/11/11/ PY - 2011/09/30/received PY - 2011/11/01/revised PY - 2011/11/05/accepted PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2012/9/29/medline SP - 122 EP - 35 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 61 N2 - The recent global increase in the abuse of 4'-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4'-methyl-N-ethylcathinone (4-MEC) and 4'-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the "legal high" NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported. SN - 1873-264X UR - https://www.unboundmedicine.com/medline/citation/22169465/Synthesis_full_chemical_characterisation_and_development_of_validated_methods_for_the_quantification_of_the_components_found_in_the_evolved_"legal_high"_NRG_2_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(11)00631-5 DB - PRIME DP - Unbound Medicine ER -