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[Correlation among the levels of C-reactive protein and interleukin-18, quality of life, and lung function in patients with chronic obstructive pulmonary disease].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Nov; 36(11):1090-6.ZN

Abstract

OBJECTIVE

To determine the correlation among the levels of C-reactive protein (CRP) and interleukin-18 (IL-18), quality of life, and pulmonary function in patients with chronic obstructive pulmonary disease (COPD),and to evaluate George's respiratory questionnaire (SGRQ).

METHODS

From October 2008 to March 2009, 39 patients with an acute exacerbation COPD (the AECOPD group), 21 patients with stable COPD (the COPD group), and 22 normal people (the control group) were enrolled in our study. The serum CRP level was measured with Beckman Coulter Immage and the IL-18 level was measured by ELISA. All subjects completed the SGRQ assessment and all patients with COPD accepted pulmonary function test.

RESULTS

The serum levels of CRP and IL-18, and SGRQ scores in the AECOPD group were significant1y higher than those in the COPD group and the control group (P<0.01). The serum levels of CRP and IL-18 and SGRQ scores in the COPD group were significant1y higher than those in the control group (P<0.01). The serum levels of CRP and IL-18 in the AECOPD group and the COPD group were negatively correlated with FEV1% and forced expiratory volume in one second (FEV1)/forced vital capacity (FVC). SGRQ scores in the AECOPD group and the COPD group were negatively correlated with FEV1% and FEV1/FVC. The serum levels of CRP, IL-18 in the AECOPD group and the COPD group were positively correlated with SGRQ scores.

CONCLUSION

CRP and IL-18 are involved in the process of inflammatory reaction of COPD, which could be markers of the acute exacerbation period of COPD. The serum levels of CRP and IL-18 might be related to the lung dysfunction and the lower quality of life in the patients with COPD. SGRQ is an effective, susceptible, and feasible method to evaluate the quality of life in patients with COPD.

Authors+Show Affiliations

Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

22169727

Citation

Long, Haiyan, et al. "[Correlation Among the Levels of C-reactive Protein and Interleukin-18, Quality of Life, and Lung Function in Patients With Chronic Obstructive Pulmonary Disease]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 36, no. 11, 2011, pp. 1090-6.
Long H, Luo H, Chen P, et al. [Correlation among the levels of C-reactive protein and interleukin-18, quality of life, and lung function in patients with chronic obstructive pulmonary disease]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36(11):1090-6.
Long, H., Luo, H., Chen, P., & Li, Y. (2011). [Correlation among the levels of C-reactive protein and interleukin-18, quality of life, and lung function in patients with chronic obstructive pulmonary disease]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 36(11), 1090-6. https://doi.org/10.3969/j.issn.1672-7347.2011.11.010
Long H, et al. [Correlation Among the Levels of C-reactive Protein and Interleukin-18, Quality of Life, and Lung Function in Patients With Chronic Obstructive Pulmonary Disease]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36(11):1090-6. PubMed PMID: 22169727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Correlation among the levels of C-reactive protein and interleukin-18, quality of life, and lung function in patients with chronic obstructive pulmonary disease]. AU - Long,Haiyan, AU - Luo,Hong, AU - Chen,Ping, AU - Li,Yan, PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2013/1/11/medline SP - 1090 EP - 6 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 36 IS - 11 N2 - OBJECTIVE: To determine the correlation among the levels of C-reactive protein (CRP) and interleukin-18 (IL-18), quality of life, and pulmonary function in patients with chronic obstructive pulmonary disease (COPD),and to evaluate George's respiratory questionnaire (SGRQ). METHODS: From October 2008 to March 2009, 39 patients with an acute exacerbation COPD (the AECOPD group), 21 patients with stable COPD (the COPD group), and 22 normal people (the control group) were enrolled in our study. The serum CRP level was measured with Beckman Coulter Immage and the IL-18 level was measured by ELISA. All subjects completed the SGRQ assessment and all patients with COPD accepted pulmonary function test. RESULTS: The serum levels of CRP and IL-18, and SGRQ scores in the AECOPD group were significant1y higher than those in the COPD group and the control group (P<0.01). The serum levels of CRP and IL-18 and SGRQ scores in the COPD group were significant1y higher than those in the control group (P<0.01). The serum levels of CRP and IL-18 in the AECOPD group and the COPD group were negatively correlated with FEV1% and forced expiratory volume in one second (FEV1)/forced vital capacity (FVC). SGRQ scores in the AECOPD group and the COPD group were negatively correlated with FEV1% and FEV1/FVC. The serum levels of CRP, IL-18 in the AECOPD group and the COPD group were positively correlated with SGRQ scores. CONCLUSION: CRP and IL-18 are involved in the process of inflammatory reaction of COPD, which could be markers of the acute exacerbation period of COPD. The serum levels of CRP and IL-18 might be related to the lung dysfunction and the lower quality of life in the patients with COPD. SGRQ is an effective, susceptible, and feasible method to evaluate the quality of life in patients with COPD. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/22169727/[Correlation_among_the_levels_of_C_reactive_protein_and_interleukin_18_quality_of_life_and_lung_function_in_patients_with_chronic_obstructive_pulmonary_disease]_ L2 - http://xbyxb.csu.edu.cn/xbwk/fileup/PDF/2011111090.pdf DB - PRIME DP - Unbound Medicine ER -