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Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma.
Am J Clin Nutr. 2012 Jan; 95(1):155-62.AJ

Abstract

BACKGROUND

The evidence for meat intake and renal cell carcinoma (RCC) risk is inconsistent. Mutagens related to meat cooking and processing, and variation by RCC subtype may be important to consider.

OBJECTIVE

In a large US cohort, we prospectively investigated intake of meat and meat-related compounds in relation to risk of RCC, as well as clear cell and papillary RCC histologic subtypes.

DESIGN

Study participants (492,186) completed a detailed dietary assessment linked to a database of heme iron, heterocyclic amines (HCA), polycyclic aromatic hydrocarbons (PAHs), nitrate, and nitrite concentrations in cooked and processed meats. Over 9 (mean) y of follow-up, we identified 1814 cases of RCC (498 clear cell and 115 papillary adenocarcinomas). HRs and 95% CIs were estimated within quintiles by using multivariable Cox proportional hazards regression.

RESULTS

Red meat intake [62.7 g (quintile 5) compared with 9.8 g (quintile 1) per 1000 kcal (median)] was associated with a tendency toward an increased risk of RCC [HR: 1.19; 95% CI: 1.01, 1.40; P-trend = 0.06] and a 2-fold increased risk of papillary RCC [P-trend = 0.002]. Intakes of benzo(a)pyrene (BaP), a marker of PAHs, and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), an HCA, were associated with a significant 20-30% elevated risk of RCC and a 2-fold increased risk of papillary RCC. No associations were observed for the clear cell subtype.

CONCLUSIONS

Red meat intake may increase the risk of RCC through mechanisms related to the cooking compounds BaP and PhIP. Our findings for RCC appeared to be driven by strong associations with the rarer papillary histologic variant. This study is registered at clinicaltrials.gov as NCT00340015.

Authors+Show Affiliations

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD, USA. carrie.daniel@nih.hhs.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

22170360

Citation

Daniel, Carrie R., et al. "Large Prospective Investigation of Meat Intake, Related Mutagens, and Risk of Renal Cell Carcinoma." The American Journal of Clinical Nutrition, vol. 95, no. 1, 2012, pp. 155-62.
Daniel CR, Cross AJ, Graubard BI, et al. Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma. Am J Clin Nutr. 2012;95(1):155-62.
Daniel, C. R., Cross, A. J., Graubard, B. I., Park, Y., Ward, M. H., Rothman, N., Hollenbeck, A. R., Chow, W. H., & Sinha, R. (2012). Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma. The American Journal of Clinical Nutrition, 95(1), 155-62. https://doi.org/10.3945/ajcn.111.019364
Daniel CR, et al. Large Prospective Investigation of Meat Intake, Related Mutagens, and Risk of Renal Cell Carcinoma. Am J Clin Nutr. 2012;95(1):155-62. PubMed PMID: 22170360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma. AU - Daniel,Carrie R, AU - Cross,Amanda J, AU - Graubard,Barry I, AU - Park,Yikyung, AU - Ward,Mary H, AU - Rothman,Nathaniel, AU - Hollenbeck,Albert R, AU - Chow,Wong-Ho, AU - Sinha,Rashmi, Y1 - 2011/12/14/ PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2012/2/18/medline SP - 155 EP - 62 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 95 IS - 1 N2 - BACKGROUND: The evidence for meat intake and renal cell carcinoma (RCC) risk is inconsistent. Mutagens related to meat cooking and processing, and variation by RCC subtype may be important to consider. OBJECTIVE: In a large US cohort, we prospectively investigated intake of meat and meat-related compounds in relation to risk of RCC, as well as clear cell and papillary RCC histologic subtypes. DESIGN: Study participants (492,186) completed a detailed dietary assessment linked to a database of heme iron, heterocyclic amines (HCA), polycyclic aromatic hydrocarbons (PAHs), nitrate, and nitrite concentrations in cooked and processed meats. Over 9 (mean) y of follow-up, we identified 1814 cases of RCC (498 clear cell and 115 papillary adenocarcinomas). HRs and 95% CIs were estimated within quintiles by using multivariable Cox proportional hazards regression. RESULTS: Red meat intake [62.7 g (quintile 5) compared with 9.8 g (quintile 1) per 1000 kcal (median)] was associated with a tendency toward an increased risk of RCC [HR: 1.19; 95% CI: 1.01, 1.40; P-trend = 0.06] and a 2-fold increased risk of papillary RCC [P-trend = 0.002]. Intakes of benzo(a)pyrene (BaP), a marker of PAHs, and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), an HCA, were associated with a significant 20-30% elevated risk of RCC and a 2-fold increased risk of papillary RCC. No associations were observed for the clear cell subtype. CONCLUSIONS: Red meat intake may increase the risk of RCC through mechanisms related to the cooking compounds BaP and PhIP. Our findings for RCC appeared to be driven by strong associations with the rarer papillary histologic variant. This study is registered at clinicaltrials.gov as NCT00340015. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22170360/Large_prospective_investigation_of_meat_intake_related_mutagens_and_risk_of_renal_cell_carcinoma_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.019364 DB - PRIME DP - Unbound Medicine ER -