Tags

Type your tag names separated by a space and hit enter

Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan.
Am J Clin Nutr 2012; 95(1):147-54AJ

Abstract

BACKGROUND

Isoflavones are structurally similar to 17β-estradiol and may be able to prevent gastric cancer. However, there is contradictory evidence concerning the relation between the intake of soy food, which is rich in isoflavones, and gastric cancer. The association with gastric cancer might differ between isoflavones and soy foods, and research on the effects of isoflavone intake alone on gastric cancer is needed.

OBJECTIVE

We investigated the association between isoflavone intake and the incidence of gastric cancer.

DESIGN

We conducted a large, population-based prospective study of 39,569 men and 45,312 women aged 45-74 y. Dietary soy and isoflavone intakes were measured by using a validated food-frequency questionnaire in 1995 and 1998.

RESULTS

During 806,550 person-years of follow-up, we identified 1249 new gastric cancer cases. Isoflavone intake was not associated with gastric cancer in either men or women. Compared with the lowest quartile, the HR and 95% CI for developing gastric cancer in the fourth quartile of isoflavone intake was 1.00 (0.81, 1.24) for men and 1.07 (0.77, 1.50) for women. In a stratified analysis by exogenous female hormones (women only), however, we found an increasing trend in risk of gastric cancer associated with higher isoflavone intakes among exogenous female hormone users (P-trend = 0.03) but not for nonusers (P-interaction = 0.04).

CONCLUSION

The current study does not support the hypothesis that higher intakes of isoflavones prevent gastric cancer in either men or women.

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22170362

Citation

Hara, Azusa, et al. "Isoflavone Intake and Risk of Gastric Cancer: a Population-based Prospective Cohort Study in Japan." The American Journal of Clinical Nutrition, vol. 95, no. 1, 2012, pp. 147-54.
Hara A, Sasazuki S, Inoue M, et al. Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan. Am J Clin Nutr. 2012;95(1):147-54.
Hara, A., Sasazuki, S., Inoue, M., Iwasaki, M., Shimazu, T., Sawada, N., ... Tsugane, S. (2012). Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan. The American Journal of Clinical Nutrition, 95(1), pp. 147-54. doi:10.3945/ajcn.111.020479.
Hara A, et al. Isoflavone Intake and Risk of Gastric Cancer: a Population-based Prospective Cohort Study in Japan. Am J Clin Nutr. 2012;95(1):147-54. PubMed PMID: 22170362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan. AU - Hara,Azusa, AU - Sasazuki,Shizuka, AU - Inoue,Manami, AU - Iwasaki,Motoki, AU - Shimazu,Taichi, AU - Sawada,Norie, AU - Yamaji,Taiki, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2011/12/14/ PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2012/2/18/medline SP - 147 EP - 54 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 1 N2 - BACKGROUND: Isoflavones are structurally similar to 17β-estradiol and may be able to prevent gastric cancer. However, there is contradictory evidence concerning the relation between the intake of soy food, which is rich in isoflavones, and gastric cancer. The association with gastric cancer might differ between isoflavones and soy foods, and research on the effects of isoflavone intake alone on gastric cancer is needed. OBJECTIVE: We investigated the association between isoflavone intake and the incidence of gastric cancer. DESIGN: We conducted a large, population-based prospective study of 39,569 men and 45,312 women aged 45-74 y. Dietary soy and isoflavone intakes were measured by using a validated food-frequency questionnaire in 1995 and 1998. RESULTS: During 806,550 person-years of follow-up, we identified 1249 new gastric cancer cases. Isoflavone intake was not associated with gastric cancer in either men or women. Compared with the lowest quartile, the HR and 95% CI for developing gastric cancer in the fourth quartile of isoflavone intake was 1.00 (0.81, 1.24) for men and 1.07 (0.77, 1.50) for women. In a stratified analysis by exogenous female hormones (women only), however, we found an increasing trend in risk of gastric cancer associated with higher isoflavone intakes among exogenous female hormone users (P-trend = 0.03) but not for nonusers (P-interaction = 0.04). CONCLUSION: The current study does not support the hypothesis that higher intakes of isoflavones prevent gastric cancer in either men or women. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22170362/Isoflavone_intake_and_risk_of_gastric_cancer:_a_population_based_prospective_cohort_study_in_Japan_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.020479 DB - PRIME DP - Unbound Medicine ER -