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Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial.
Am J Clin Nutr 2012; 95(1):49-63AJ

Abstract

BACKGROUND

The most effective and safe dietary approach for weight loss and its impact on the metabolic functions and morphology of adipose tissue remain unclear.

OBJECTIVES

We evaluated whether an energy-restricted high-protein diet with a low glycemic index and soluble fiber (LC-P-LGI) would be more effective than a low-calorie conventional diet (LC-CONV) on weight loss and related metabolic risk factors. We further determined factors that may influence adipocyte size during energy restriction.

DESIGN

Thirteen obese participants were randomly assigned in a crossover design to 2 periods of a 4-wk hypocaloric diet as either LC-P-LGI or LC-CONV, separated by 8-wk washout intervals.

RESULTS

In comparison with the LC-CONV diet, the main effect of the LC-P-LGI diet was a greater decrease in adipocyte diameter (P = 0.048), plasma plasminogen activator inhibitor protein-1 (P = 0.019), vascular endothelial growth factor (P = 0.032), and interferon-γ inducible protein 10 (P = 0.010). Whereas fasting plasma glucose and high-sensitivity C-reactive protein decreased only after the LC-P-LGI diet, with no differences between diets, fasting plasma insulin and insulin resistance were lower after the LC-CONV diet. The diet results did not differ for body composition and lipid variables. Kinetic modifications in adipocyte diameter were associated with metabolic variables and genes implicated in adipocyte proliferation, apoptosis, and angiogenesis.

CONCLUSIONS

In comparison with the LC-CONV diet, the LC-P-LGI diet was associated with improvement in some cardiometabolic risk factors and greater reduction in adipocyte size. Profiles of genes involved in inhibiting adipogenesis and angiogenesis, but increasing apoptosis, were correlated with decreased adipocyte size. This study provides insight into the adipose tissue-remodeling changes that induce regulation of adipocyte size during dietary weight loss. This trial was registered at clinicaltrials.gov as NCT01312740.

Authors+Show Affiliations

INSERM, U, Nutriomique Team 7, Centre de Recherche des Cordeliers, UMR S, Paris, France. salwa.rizkalla@psl.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22170375

Citation

Rizkalla, Salwa W., et al. "Differential Effects of Macronutrient Content in 2 Energy-restricted Diets On Cardiovascular Risk Factors and Adipose Tissue Cell Size in Moderately Obese Individuals: a Randomized Controlled Trial." The American Journal of Clinical Nutrition, vol. 95, no. 1, 2012, pp. 49-63.
Rizkalla SW, Prifti E, Cotillard A, et al. Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial. Am J Clin Nutr. 2012;95(1):49-63.
Rizkalla, S. W., Prifti, E., Cotillard, A., Pelloux, V., Rouault, C., Allouche, R., ... Clement, K. (2012). Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial. The American Journal of Clinical Nutrition, 95(1), pp. 49-63. doi:10.3945/ajcn.111.017277.
Rizkalla SW, et al. Differential Effects of Macronutrient Content in 2 Energy-restricted Diets On Cardiovascular Risk Factors and Adipose Tissue Cell Size in Moderately Obese Individuals: a Randomized Controlled Trial. Am J Clin Nutr. 2012;95(1):49-63. PubMed PMID: 22170375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial. AU - Rizkalla,Salwa W, AU - Prifti,Edi, AU - Cotillard,Aurélie, AU - Pelloux,Veronique, AU - Rouault,Christine, AU - Allouche,Reginald, AU - Laromiguière,Muriel, AU - Kong,LingChun, AU - Darakhshan,Froogh, AU - Massiera,Florence, AU - Clement,Karine, Y1 - 2011/12/14/ PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2012/2/18/medline SP - 49 EP - 63 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 1 N2 - BACKGROUND: The most effective and safe dietary approach for weight loss and its impact on the metabolic functions and morphology of adipose tissue remain unclear. OBJECTIVES: We evaluated whether an energy-restricted high-protein diet with a low glycemic index and soluble fiber (LC-P-LGI) would be more effective than a low-calorie conventional diet (LC-CONV) on weight loss and related metabolic risk factors. We further determined factors that may influence adipocyte size during energy restriction. DESIGN: Thirteen obese participants were randomly assigned in a crossover design to 2 periods of a 4-wk hypocaloric diet as either LC-P-LGI or LC-CONV, separated by 8-wk washout intervals. RESULTS: In comparison with the LC-CONV diet, the main effect of the LC-P-LGI diet was a greater decrease in adipocyte diameter (P = 0.048), plasma plasminogen activator inhibitor protein-1 (P = 0.019), vascular endothelial growth factor (P = 0.032), and interferon-γ inducible protein 10 (P = 0.010). Whereas fasting plasma glucose and high-sensitivity C-reactive protein decreased only after the LC-P-LGI diet, with no differences between diets, fasting plasma insulin and insulin resistance were lower after the LC-CONV diet. The diet results did not differ for body composition and lipid variables. Kinetic modifications in adipocyte diameter were associated with metabolic variables and genes implicated in adipocyte proliferation, apoptosis, and angiogenesis. CONCLUSIONS: In comparison with the LC-CONV diet, the LC-P-LGI diet was associated with improvement in some cardiometabolic risk factors and greater reduction in adipocyte size. Profiles of genes involved in inhibiting adipogenesis and angiogenesis, but increasing apoptosis, were correlated with decreased adipocyte size. This study provides insight into the adipose tissue-remodeling changes that induce regulation of adipocyte size during dietary weight loss. This trial was registered at clinicaltrials.gov as NCT01312740. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22170375/Differential_effects_of_macronutrient_content_in_2_energy_restricted_diets_on_cardiovascular_risk_factors_and_adipose_tissue_cell_size_in_moderately_obese_individuals:_a_randomized_controlled_trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.017277 DB - PRIME DP - Unbound Medicine ER -