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Evaluation of latent links between irritable bowel syndrome and sleep quality.
World J Gastroenterol 2011; 17(46):5089-96WJ

Abstract

AIM

To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bowel syndrome (IBS).

METHODS

One hundred and forty-two outpatients (110 female, 32 male) who met the Rome III criteria for IBS with no psychiatric comorbidity were consecutively enrolled in this study. Data on age, body mass index (BMI), and a set of life-habit variables were recorded, and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score (IBS-SSS) and Pittsburgh Sleep Quality Index (PSQI). The association between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score (Pearson's correlation and Fisher's exact test) and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory (IRT).

RESULTS

IBS-SSS ranged from mild to severe (120-470). The global PSQI score ranged from 1 to 17 (median 5), and 60 patients were found to be poor sleepers (PSQI > 5). The correlation between the global IBS-SSS and PSQI score indicated a weak association (r = 0.2 and 95% CI: -0.03 to 0.35, P < 0.05), which becomes stronger using our unitary model. Indeed, the IBS and sleep disturbances severities, estimated as latent variables, resulted significantly high intra-subject correlation (posterior mean of r = 0.45 and 95% CI: 0.17 to 0.70, P < 0.05). Moreover, the correlations between patient features (age, sex, BMI, daily coffee and alcohol intake) and IBS and sleep disturbances were also analyzed through our unitary model. Age was a significant regressor, with patients ≤ 50 years old showing more severe bowel disturbances (posterior mean = -0.38, P < 0.05) and less severe sleep disturbances (posterior mean = 0.49, P < 0.05) than older patients. Higher daily coffee intake was correlated with a lower severity of bowel disturbances (posterior mean = -0.31, P < 0.05). Sex (female) and daily alcohol intake (modest) were correlated with less severe sleep disturbances.

CONCLUSION

The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances.

Authors+Show Affiliations

Gastrointestinal Unit, Department of Gastroenterology, University of Pisa, 56100 Pisa, Italy. mbellini@med.unipi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22171143

Citation

Bellini, Massimo, et al. "Evaluation of Latent Links Between Irritable Bowel Syndrome and Sleep Quality." World Journal of Gastroenterology, vol. 17, no. 46, 2011, pp. 5089-96.
Bellini M, Gemignani A, Gambaccini D, et al. Evaluation of latent links between irritable bowel syndrome and sleep quality. World J Gastroenterol. 2011;17(46):5089-96.
Bellini, M., Gemignani, A., Gambaccini, D., Toti, S., Menicucci, D., Stasi, C., ... Marchi, S. (2011). Evaluation of latent links between irritable bowel syndrome and sleep quality. World Journal of Gastroenterology, 17(46), pp. 5089-96. doi:10.3748/wjg.v17.i46.5089.
Bellini M, et al. Evaluation of Latent Links Between Irritable Bowel Syndrome and Sleep Quality. World J Gastroenterol. 2011 Dec 14;17(46):5089-96. PubMed PMID: 22171143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of latent links between irritable bowel syndrome and sleep quality. AU - Bellini,Massimo, AU - Gemignani,Angelo, AU - Gambaccini,Dario, AU - Toti,Simona, AU - Menicucci,Danilo, AU - Stasi,Cristina, AU - Costa,Francesco, AU - Mumolo,Maria Gloria, AU - Ricchiuti,Angelo, AU - Bedini,Remo, AU - de Bortoli,Nicola, AU - Marchi,Santino, PY - 2011/01/31/received PY - 2011/03/28/revised PY - 2011/04/05/accepted PY - 2011/12/16/entrez PY - 2011/12/16/pubmed PY - 2012/3/3/medline KW - Bayesian model KW - Irritable bowel syndrome KW - Item response theory model KW - Sleep disorders SP - 5089 EP - 96 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 17 IS - 46 N2 - AIM: To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bowel syndrome (IBS). METHODS: One hundred and forty-two outpatients (110 female, 32 male) who met the Rome III criteria for IBS with no psychiatric comorbidity were consecutively enrolled in this study. Data on age, body mass index (BMI), and a set of life-habit variables were recorded, and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score (IBS-SSS) and Pittsburgh Sleep Quality Index (PSQI). The association between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score (Pearson's correlation and Fisher's exact test) and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory (IRT). RESULTS: IBS-SSS ranged from mild to severe (120-470). The global PSQI score ranged from 1 to 17 (median 5), and 60 patients were found to be poor sleepers (PSQI > 5). The correlation between the global IBS-SSS and PSQI score indicated a weak association (r = 0.2 and 95% CI: -0.03 to 0.35, P < 0.05), which becomes stronger using our unitary model. Indeed, the IBS and sleep disturbances severities, estimated as latent variables, resulted significantly high intra-subject correlation (posterior mean of r = 0.45 and 95% CI: 0.17 to 0.70, P < 0.05). Moreover, the correlations between patient features (age, sex, BMI, daily coffee and alcohol intake) and IBS and sleep disturbances were also analyzed through our unitary model. Age was a significant regressor, with patients ≤ 50 years old showing more severe bowel disturbances (posterior mean = -0.38, P < 0.05) and less severe sleep disturbances (posterior mean = 0.49, P < 0.05) than older patients. Higher daily coffee intake was correlated with a lower severity of bowel disturbances (posterior mean = -0.31, P < 0.05). Sex (female) and daily alcohol intake (modest) were correlated with less severe sleep disturbances. CONCLUSION: The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/22171143/Evaluation_of_latent_links_between_irritable_bowel_syndrome_and_sleep_quality_ L2 - http://www.wjgnet.com/1007-9327/full/v17/i46/5089.htm DB - PRIME DP - Unbound Medicine ER -