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Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008.
Emerg Infect Dis. 2011 Dec; 17(12):2223-31.EI

Abstract

Hand, foot, and mouth disease (HFMD), a common disease caused by enteroviruses (EVs), usually affects children. Clustered and sporadic HFMD cases, followed by onychomadesis (nail shedding), occurred during summer and fall 2008 in Valencia, Spain. Fecal samples from onychomadesis patients, who did or did not have previous HFMD, and from healthy children exposed to onychomadesis patients tested positive for EV. The complete viral protein 1 capsid gene sequence was obtained for typing and phylogenetic analysis. Two EV serotypes, coxsackievirus A10 and coxsackievirus B1 (CVB1), were mainly detected as a monoinfection or co-infection in a childcare center where an onychomadesis outbreak occurred. On the basis of our results, and detection of CVB1 in 2 other contemporary onychomadesis outbreaks in childcare centers in Spain, we propose that mixed infection of an EV serotype that causes HFMD, plus the serotype CVB1, could explain the emergence after HFMD of onychomadesis, a rare and late complication.

Authors+Show Affiliations

Centro Superior de Investigación en Salud Pública, Valencia, Spain. alma.bracho@uv.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22172227

Citation

Bracho, Maria A., et al. "Enterovirus Co-infections and Onychomadesis After Hand, Foot, and Mouth Disease, Spain, 2008." Emerging Infectious Diseases, vol. 17, no. 12, 2011, pp. 2223-31.
Bracho MA, González-Candelas F, Valero A, et al. Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008. Emerg Infect Dis. 2011;17(12):2223-31.
Bracho, M. A., González-Candelas, F., Valero, A., Córdoba, J., & Salazar, A. (2011). Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008. Emerging Infectious Diseases, 17(12), 2223-31. https://doi.org/10.3201/eid1712.110395
Bracho MA, et al. Enterovirus Co-infections and Onychomadesis After Hand, Foot, and Mouth Disease, Spain, 2008. Emerg Infect Dis. 2011;17(12):2223-31. PubMed PMID: 22172227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008. AU - Bracho,Maria A, AU - González-Candelas,Fernando, AU - Valero,Ana, AU - Córdoba,Juan, AU - Salazar,Antonio, PY - 2011/12/17/entrez PY - 2011/12/17/pubmed PY - 2012/5/1/medline SP - 2223 EP - 31 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 17 IS - 12 N2 - Hand, foot, and mouth disease (HFMD), a common disease caused by enteroviruses (EVs), usually affects children. Clustered and sporadic HFMD cases, followed by onychomadesis (nail shedding), occurred during summer and fall 2008 in Valencia, Spain. Fecal samples from onychomadesis patients, who did or did not have previous HFMD, and from healthy children exposed to onychomadesis patients tested positive for EV. The complete viral protein 1 capsid gene sequence was obtained for typing and phylogenetic analysis. Two EV serotypes, coxsackievirus A10 and coxsackievirus B1 (CVB1), were mainly detected as a monoinfection or co-infection in a childcare center where an onychomadesis outbreak occurred. On the basis of our results, and detection of CVB1 in 2 other contemporary onychomadesis outbreaks in childcare centers in Spain, we propose that mixed infection of an EV serotype that causes HFMD, plus the serotype CVB1, could explain the emergence after HFMD of onychomadesis, a rare and late complication. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/22172227/Enterovirus_co_infections_and_onychomadesis_after_hand_foot_and_mouth_disease_Spain_2008_ L2 - https://dx.doi.org/10.3201/eid1712.110395 DB - PRIME DP - Unbound Medicine ER -