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Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it.
Neuroscience. 2012 Mar 01; 204:159-85.N

Abstract

The endocannabinoid system seems to play very specific roles in fear extinction, which can only be described within a well-defined model of the various fear relief processes. We, therefore, seek to clarify the current conceptual framework of fear relief within classical and operant fear conditioning paradigms as well as propose new clarifications within this framework where necessary. Based on these revisions as well as previous research involving the endocannabinoid system and fear relief, we are able to pinpoint the processes in which endocannabinoids seem to play a significant role. Following auditory-cued fear conditioning, this applies in particular to habituation and its involvement in acute and long-lasting fear relief. Following contextual conditioning, in contrast, endocannabinoids seem to affect relearning processes as well. Furthermore, we describe how the involvement of the endocannabinoid system develops over the course of the fear relief process and what this may imply for the clinical use of pharmacotherapies targeting the endocannabinoid system in treating fear and anxiety disorders.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Research Group Neuronal Plasticity, Kraepelinstr. 2, D-80804, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22173015

Citation

Riebe, C J., et al. "Fear Relief-toward a New Conceptual Frame Work and what Endocannabinoids Gotta Do With It." Neuroscience, vol. 204, 2012, pp. 159-85.
Riebe CJ, Pamplona FA, Pamplona F, et al. Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it. Neuroscience. 2012;204:159-85.
Riebe, C. J., Pamplona, F. A., Pamplona, F., Kamprath, K., & Wotjak, C. T. (2012). Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it. Neuroscience, 204, 159-85. https://doi.org/10.1016/j.neuroscience.2011.11.057
Riebe CJ, et al. Fear Relief-toward a New Conceptual Frame Work and what Endocannabinoids Gotta Do With It. Neuroscience. 2012 Mar 1;204:159-85. PubMed PMID: 22173015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it. AU - Riebe,C J, AU - Pamplona,F A, AU - Pamplona,F, AU - Kamprath,K, AU - Wotjak,C T, Y1 - 2011/12/03/ PY - 2011/10/04/received PY - 2011/11/21/accepted PY - 2011/12/17/entrez PY - 2011/12/17/pubmed PY - 2012/7/24/medline SP - 159 EP - 85 JF - Neuroscience JO - Neuroscience VL - 204 N2 - The endocannabinoid system seems to play very specific roles in fear extinction, which can only be described within a well-defined model of the various fear relief processes. We, therefore, seek to clarify the current conceptual framework of fear relief within classical and operant fear conditioning paradigms as well as propose new clarifications within this framework where necessary. Based on these revisions as well as previous research involving the endocannabinoid system and fear relief, we are able to pinpoint the processes in which endocannabinoids seem to play a significant role. Following auditory-cued fear conditioning, this applies in particular to habituation and its involvement in acute and long-lasting fear relief. Following contextual conditioning, in contrast, endocannabinoids seem to affect relearning processes as well. Furthermore, we describe how the involvement of the endocannabinoid system develops over the course of the fear relief process and what this may imply for the clinical use of pharmacotherapies targeting the endocannabinoid system in treating fear and anxiety disorders. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/22173015/Fear_relief_toward_a_new_conceptual_frame_work_and_what_endocannabinoids_gotta_do_with_it_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(11)01344-3 DB - PRIME DP - Unbound Medicine ER -