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Subclinical carotid atherosclerosis and cardiovascular risk factors in HIV-infected patients.

Abstract

BACKGROUND

HIV infected patients, especially those treated with antiretroviral (ARV) drugs, show an increased risk and incidence of cardiovascular disease.

OBJECTIVES

The aim of this study was to evaluate the progression of subclinical atherosclerosis in the carotid arteries, expressed as the value of carotid intima-media thickness (cIMT) and the amount of atherosclerotic plaques, and to analyze the correlation between cIMT and risk factors for cardiovascular diseases in a cohort of HIV infected patients.

METHODS

The analysis included 72 HIV infected patients, mean age 39.4 years, and 27 healthy HIV negative individuals, matched for age and sex. The data collected included evaluation of the infection, ARV treatment, past cardiovascular events, assessment of traditional and nontraditional risk factors for cardiovascular diseases, cIMT measurements and amount of atherosclerotic plaques in the carotid arteries.

RESULTS

HIV infected patients show more advanced subclinical atherosclerosis in the carotid arteries (cIMT and plaques incidence). The cardiovascular risk profile of the HIV infected patients is significantly different from HIV negative people. Among the HIV positive group lower body mass index (BMI) and higher waist/hip ratio (WHR) are observed. The concentration of all cholesterol fractions is lower, whereas the concentration of triglycerides is higher. Cigarette smoking is more common among HIV-infected individuals. A strong statistical correlation between cIMT and age, hypertension, non-high-density lipoprotein (non-HDL) cholesterol and ARV time were found. Total and LDL cholesterol, and lifetime smoking exposure also affect the cIMT. The relationship between cIMT and current HIV RNA may indicate the impact of the current infection status on the cIMT dynamics in this subpopulation.

Authors+Show Affiliations

Department of Angiology, Regional Specialist Hospital in Wroclaw, Research and Development Center, Poland. kwiatkowska_w@interia.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22173442

Citation

Kwiatkowska, Wiesława, et al. "Subclinical Carotid Atherosclerosis and Cardiovascular Risk Factors in HIV-infected Patients." Postepy Higieny I Medycyny Doswiadczalnej (Online), vol. 65, 2011, pp. 770-83.
Kwiatkowska W, Knysz B, Drelichowska-Durawa J, et al. Subclinical carotid atherosclerosis and cardiovascular risk factors in HIV-infected patients. Postepy Hig Med Dosw (Online). 2011;65:770-83.
Kwiatkowska, W., Knysz, B., Drelichowska-Durawa, J., Czarnecki, M., Gąsiorowski, J., Biłyk, E., ... Witkiewicz, W. (2011). Subclinical carotid atherosclerosis and cardiovascular risk factors in HIV-infected patients. Postepy Higieny I Medycyny Doswiadczalnej (Online), 65, pp. 770-83.
Kwiatkowska W, et al. Subclinical Carotid Atherosclerosis and Cardiovascular Risk Factors in HIV-infected Patients. Postepy Hig Med Dosw (Online). 2011 Nov 25;65:770-83. PubMed PMID: 22173442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subclinical carotid atherosclerosis and cardiovascular risk factors in HIV-infected patients. AU - Kwiatkowska,Wiesława, AU - Knysz,Brygida, AU - Drelichowska-Durawa,Justyna, AU - Czarnecki,Marcin, AU - Gąsiorowski,Jacek, AU - Biłyk,Ewa, AU - Karczewski,Maciej, AU - Witkiewicz,Wojciech, Y1 - 2011/11/25/ PY - 2011/12/17/entrez PY - 2011/12/17/pubmed PY - 2012/5/23/medline SP - 770 EP - 83 JF - Postepy higieny i medycyny doswiadczalnej (Online) JO - Postepy Hig Med Dosw (Online) VL - 65 N2 - BACKGROUND: HIV infected patients, especially those treated with antiretroviral (ARV) drugs, show an increased risk and incidence of cardiovascular disease. OBJECTIVES: The aim of this study was to evaluate the progression of subclinical atherosclerosis in the carotid arteries, expressed as the value of carotid intima-media thickness (cIMT) and the amount of atherosclerotic plaques, and to analyze the correlation between cIMT and risk factors for cardiovascular diseases in a cohort of HIV infected patients. METHODS: The analysis included 72 HIV infected patients, mean age 39.4 years, and 27 healthy HIV negative individuals, matched for age and sex. The data collected included evaluation of the infection, ARV treatment, past cardiovascular events, assessment of traditional and nontraditional risk factors for cardiovascular diseases, cIMT measurements and amount of atherosclerotic plaques in the carotid arteries. RESULTS: HIV infected patients show more advanced subclinical atherosclerosis in the carotid arteries (cIMT and plaques incidence). The cardiovascular risk profile of the HIV infected patients is significantly different from HIV negative people. Among the HIV positive group lower body mass index (BMI) and higher waist/hip ratio (WHR) are observed. The concentration of all cholesterol fractions is lower, whereas the concentration of triglycerides is higher. Cigarette smoking is more common among HIV-infected individuals. A strong statistical correlation between cIMT and age, hypertension, non-high-density lipoprotein (non-HDL) cholesterol and ARV time were found. Total and LDL cholesterol, and lifetime smoking exposure also affect the cIMT. The relationship between cIMT and current HIV RNA may indicate the impact of the current infection status on the cIMT dynamics in this subpopulation. SN - 1732-2693 UR - https://www.unboundmedicine.com/medline/citation/22173442/Subclinical_carotid_atherosclerosis_and_cardiovascular_risk_factors_in_HIV_infected_patients_ L2 - http://www.phmd.pl/fulltxt.php?ICID=967075 DB - PRIME DP - Unbound Medicine ER -