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[Expression of cytokine IL-1α and S100β in different types of plaques in Alzheimer's disease].
Zhonghua Bing Li Xue Za Zhi 2011; 40(9):581-4ZB

Abstract

OBJECTIVE

To study the significance of cytokine IL-1α and S100β expression in formation and evolution of different types of plaques in Alzheimer's disease.

METHODS

Thirty-four autopsy cases of Alzheimer's disease encountered during the period from 1982 to 2008 were retrieved from the archival files of Department of Pathology, Beijing Hospital. Tissue blocks were taken from hippocampus for dual immunostaining for IL-1α/Aβ and S100β/Aβ.

RESULTS

Immunohistochemical studied for IL-1α/Aβ and S100β/Aβ delineated four different types of senile plaques: diffuse non-neuritic plaques, diffuse neuritic plaques, dense-core neuritic plaques and dense-core non-neuritic plaques. The numbers of IL-1α-positive microglias and S100β-positive astrocytes associated with diffuse neuritic plaques were (7.29 ± 3.04) per mm(2) and (6.49 ± 2.20) per mm(2), respectively. In contrast, the numbers of IL-1α-positive microglias and S100β-positive astrocytes associated with diffuse non-neuritic plaques, dense-core neuritic plaques and dense-core non-neuritic plaques were (3.24 ± 1.53) per mm(2) and (4.14 ± 1.77) per mm(2), (2.09 ± 1.37) per mm(2) and (2.25 ± 0.83) per mm(2), and (1.38 ± 0.90) per mm(2) and (0.58 ± 0.36) per mm(2), respectively. The numbers of IL-1α-positive microglias and S100β-positive astrocytes associated with diffuse neuritic plaques were significantly higher than those of the other three types of plaques (P < 0.05).

CONCLUSION

The IL-1α-positive microglias and S100β-positive astrocytes may be of certain significance in transformation of diffuse non-neuritic plaques to diffuse neuritic plaques in Alzheimer's disease.

Authors+Show Affiliations

Department of Pathology, Beijing Hospital, Beijing 100730, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

22177239

Citation

Yao, Jing-jing, et al. "[Expression of Cytokine IL-1α and S100β in Different Types of Plaques in Alzheimer's Disease]." Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology, vol. 40, no. 9, 2011, pp. 581-4.
Yao JJ, He SR, Chen L, et al. [Expression of cytokine IL-1α and S100β in different types of plaques in Alzheimer's disease]. Zhonghua Bing Li Xue Za Zhi. 2011;40(9):581-4.
Yao, J. J., He, S. R., Chen, L., Yang, L., Qiao, X. B., Zhang, W., ... Liu, D. G. (2011). [Expression of cytokine IL-1α and S100β in different types of plaques in Alzheimer's disease]. Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology, 40(9), pp. 581-4.
Yao JJ, et al. [Expression of Cytokine IL-1α and S100β in Different Types of Plaques in Alzheimer's Disease]. Zhonghua Bing Li Xue Za Zhi. 2011;40(9):581-4. PubMed PMID: 22177239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of cytokine IL-1α and S100β in different types of plaques in Alzheimer's disease]. AU - Yao,Jing-jing, AU - He,Shu-rong, AU - Chen,Lan, AU - Yang,Li, AU - Qiao,Xu-bai, AU - Zhang,Wei, AU - Du,Jun, AU - Liu,Dong-ge, PY - 2011/12/20/entrez PY - 2011/12/20/pubmed PY - 2012/4/6/medline SP - 581 EP - 4 JF - Zhonghua bing li xue za zhi = Chinese journal of pathology JO - Zhonghua Bing Li Xue Za Zhi VL - 40 IS - 9 N2 - OBJECTIVE: To study the significance of cytokine IL-1α and S100β expression in formation and evolution of different types of plaques in Alzheimer's disease. METHODS: Thirty-four autopsy cases of Alzheimer's disease encountered during the period from 1982 to 2008 were retrieved from the archival files of Department of Pathology, Beijing Hospital. Tissue blocks were taken from hippocampus for dual immunostaining for IL-1α/Aβ and S100β/Aβ. RESULTS: Immunohistochemical studied for IL-1α/Aβ and S100β/Aβ delineated four different types of senile plaques: diffuse non-neuritic plaques, diffuse neuritic plaques, dense-core neuritic plaques and dense-core non-neuritic plaques. The numbers of IL-1α-positive microglias and S100β-positive astrocytes associated with diffuse neuritic plaques were (7.29 ± 3.04) per mm(2) and (6.49 ± 2.20) per mm(2), respectively. In contrast, the numbers of IL-1α-positive microglias and S100β-positive astrocytes associated with diffuse non-neuritic plaques, dense-core neuritic plaques and dense-core non-neuritic plaques were (3.24 ± 1.53) per mm(2) and (4.14 ± 1.77) per mm(2), (2.09 ± 1.37) per mm(2) and (2.25 ± 0.83) per mm(2), and (1.38 ± 0.90) per mm(2) and (0.58 ± 0.36) per mm(2), respectively. The numbers of IL-1α-positive microglias and S100β-positive astrocytes associated with diffuse neuritic plaques were significantly higher than those of the other three types of plaques (P < 0.05). CONCLUSION: The IL-1α-positive microglias and S100β-positive astrocytes may be of certain significance in transformation of diffuse non-neuritic plaques to diffuse neuritic plaques in Alzheimer's disease. SN - 0529-5807 UR - https://www.unboundmedicine.com/medline/citation/22177239/[Expression_of_cytokine_IL_1α_and_S100β_in_different_types_of_plaques_in_Alzheimer's_disease]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0529-5807&amp;year=2011&amp;vol=40&amp;issue=9&amp;fpage=581 DB - PRIME DP - Unbound Medicine ER -