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Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients.
Biol Psychiatry. 2012 Apr 01; 71(7):611-7.BP

Abstract

BACKGROUND

Imaging studies have shown that major depressive disorder (MDD) is associated with altered activity patterns of the default mode network (DMN). However, the neural correlates of the resting-state DMN and MDD-related pathopsychological characteristics, such as depressive rumination and overgeneral autobiographical memory (OGM) phenomena, still remain unclear.

METHODS

Using independent component analysis, we analyzed resting-state functional magnetic resonance imaging data obtained from 35 first-episode, treatment-naive young adults with MDD and from 35 matched healthy control subjects.

RESULTS

Patients with MDD exhibited higher levels of rumination and OGM than did the control subjects. We observed increased functional connectivity in the anterior medial cortex regions (especially the medial prefrontal cortex and anterior cingulate cortex) and decreased functional connectivity in the posterior medial cortex regions (especially the posterior cingulate cortex/precuneus) in MDD patients compared with control subjects. In the depressed group, the increased functional connectivity in the anterior medial cortex correlated positively with rumination score, while the decreased functional connectivity in the posterior medial cortex correlated negatively with OGM score.

CONCLUSIONS

We report dissociation between anterior and posterior functional connectivity in resting-state DMNs of first-episode, treatment-naive young adults with MDD. Increased functional connectivity in anterior medial regions of the resting-state DMN was associated with rumination, whereas decreased functional connectivity in posterior medial regions was associated with OGM. These results provide new evidence for the importance of the DMN in the pathophysiology of MDD and suggest that abnormal DMN activity may be an MDD trait.

Authors+Show Affiliations

Medical Psychological Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22177602

Citation

Zhu, Xueling, et al. "Evidence of a Dissociation Pattern in Resting-state Default Mode Network Connectivity in First-episode, Treatment-naive Major Depression Patients." Biological Psychiatry, vol. 71, no. 7, 2012, pp. 611-7.
Zhu X, Wang X, Xiao J, et al. Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients. Biol Psychiatry. 2012;71(7):611-7.
Zhu, X., Wang, X., Xiao, J., Liao, J., Zhong, M., Wang, W., & Yao, S. (2012). Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients. Biological Psychiatry, 71(7), 611-7. https://doi.org/10.1016/j.biopsych.2011.10.035
Zhu X, et al. Evidence of a Dissociation Pattern in Resting-state Default Mode Network Connectivity in First-episode, Treatment-naive Major Depression Patients. Biol Psychiatry. 2012 Apr 1;71(7):611-7. PubMed PMID: 22177602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients. AU - Zhu,Xueling, AU - Wang,Xiang, AU - Xiao,Jin, AU - Liao,Jian, AU - Zhong,Mingtian, AU - Wang,Wei, AU - Yao,Shuqiao, Y1 - 2011/12/15/ PY - 2011/01/08/received PY - 2011/09/28/revised PY - 2011/10/30/accepted PY - 2011/12/20/entrez PY - 2011/12/20/pubmed PY - 2012/7/18/medline SP - 611 EP - 7 JF - Biological psychiatry JO - Biol. Psychiatry VL - 71 IS - 7 N2 - BACKGROUND: Imaging studies have shown that major depressive disorder (MDD) is associated with altered activity patterns of the default mode network (DMN). However, the neural correlates of the resting-state DMN and MDD-related pathopsychological characteristics, such as depressive rumination and overgeneral autobiographical memory (OGM) phenomena, still remain unclear. METHODS: Using independent component analysis, we analyzed resting-state functional magnetic resonance imaging data obtained from 35 first-episode, treatment-naive young adults with MDD and from 35 matched healthy control subjects. RESULTS: Patients with MDD exhibited higher levels of rumination and OGM than did the control subjects. We observed increased functional connectivity in the anterior medial cortex regions (especially the medial prefrontal cortex and anterior cingulate cortex) and decreased functional connectivity in the posterior medial cortex regions (especially the posterior cingulate cortex/precuneus) in MDD patients compared with control subjects. In the depressed group, the increased functional connectivity in the anterior medial cortex correlated positively with rumination score, while the decreased functional connectivity in the posterior medial cortex correlated negatively with OGM score. CONCLUSIONS: We report dissociation between anterior and posterior functional connectivity in resting-state DMNs of first-episode, treatment-naive young adults with MDD. Increased functional connectivity in anterior medial regions of the resting-state DMN was associated with rumination, whereas decreased functional connectivity in posterior medial regions was associated with OGM. These results provide new evidence for the importance of the DMN in the pathophysiology of MDD and suggest that abnormal DMN activity may be an MDD trait. SN - 1873-2402 UR - https://www.unboundmedicine.com/medline/citation/22177602/Evidence_of_a_dissociation_pattern_in_resting_state_default_mode_network_connectivity_in_first_episode_treatment_naive_major_depression_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(11)01103-6 DB - PRIME DP - Unbound Medicine ER -