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Effects of Ficus carica paste on loperamide-induced constipation in rats.
Food Chem Toxicol. 2012 Mar; 50(3-4):895-902.FC

Abstract

OBJECTIVE

Constipation is one of the most common gastrointestinal complaints worldwide. This study examined the effects of fig (Ficus carica L.) paste for the treatment of loperamide-induced constipation in a rat model.

METHODS

Animals were divided into one normal control group and four experimental groups (0, 1, 6, and 30 g/kg). Loperamide (2 mg/kg, twice per day) was injected intraperitoneally to induce constipation in the four experimental groups. Fig paste was administered for 4 weeks to assess its anti-constipation effects.

RESULTS

Fecal pellet number, weight and water content were increased in the fig-treated groups as compared to the control group. Reductions in body weight and increased intestinal transit length were observed in the fig-treated groups. Fecal pellet number was reduced in the distal colons of the fig-treated rats. Exercise and ileum tension increased in the experimental groups as compared to the control group. According to histological analyses, the thickness of the distal colon and areas of crypt epithelial cells that produce mucin were increased in the fig-treated groups in a dose-dependent manner.

CONCLUSION

Constipation was decreased when fig fruit was fed to rats. Specifically, fecal number, weight, and water content, as well as histological parameters such as thickness and mucin areas in the distal colon were improved. Fig treatment may be a useful therapeutic and preventive strategy for chronic constipation.

Authors+Show Affiliations

BIOSOLOMON, Inc., Jeonju, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22178225

Citation

Lee, Hak-Yong, et al. "Effects of Ficus Carica Paste On Loperamide-induced Constipation in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 50, no. 3-4, 2012, pp. 895-902.
Lee HY, Kim JH, Jeung HW, et al. Effects of Ficus carica paste on loperamide-induced constipation in rats. Food Chem Toxicol. 2012;50(3-4):895-902.
Lee, H. Y., Kim, J. H., Jeung, H. W., Lee, C. U., Kim, D. S., Li, B., Lee, G. H., Sung, M. S., Ha, K. C., Back, H. I., Kim, S. Y., Park, S. H., Oh, M. R., Kim, M. G., Jeon, J. Y., Im, Y. J., Hwang, M. H., So, B. O., Shin, S. J., ... Chae, S. W. (2012). Effects of Ficus carica paste on loperamide-induced constipation in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 50(3-4), 895-902. https://doi.org/10.1016/j.fct.2011.12.001
Lee HY, et al. Effects of Ficus Carica Paste On Loperamide-induced Constipation in Rats. Food Chem Toxicol. 2012;50(3-4):895-902. PubMed PMID: 22178225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Ficus carica paste on loperamide-induced constipation in rats. AU - Lee,Hak-Yong, AU - Kim,Jung-Hoon, AU - Jeung,Han-Wool, AU - Lee,Cha-Uk, AU - Kim,Do-Sung, AU - Li,Bo, AU - Lee,Geum-Hwa, AU - Sung,Myung-Soon, AU - Ha,Ki-Chan, AU - Back,Hyang-Im, AU - Kim,Sun-Young, AU - Park,Soo-Hyun, AU - Oh,Mi-Ra, AU - Kim,Min-Gul, AU - Jeon,Ji-Young, AU - Im,Yong-Jin, AU - Hwang,Min-Ho, AU - So,Byung-Ok, AU - Shin,Sook-Jeong, AU - Yoo,Wan-Hee, AU - Kim,Hyung-Ryong, AU - Chae,Han-Jung, AU - Chae,Soo-Wan, Y1 - 2011/12/09/ PY - 2011/03/28/received PY - 2011/09/11/revised PY - 2011/12/01/accepted PY - 2011/12/20/entrez PY - 2011/12/20/pubmed PY - 2012/7/17/medline SP - 895 EP - 902 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 50 IS - 3-4 N2 - OBJECTIVE: Constipation is one of the most common gastrointestinal complaints worldwide. This study examined the effects of fig (Ficus carica L.) paste for the treatment of loperamide-induced constipation in a rat model. METHODS: Animals were divided into one normal control group and four experimental groups (0, 1, 6, and 30 g/kg). Loperamide (2 mg/kg, twice per day) was injected intraperitoneally to induce constipation in the four experimental groups. Fig paste was administered for 4 weeks to assess its anti-constipation effects. RESULTS: Fecal pellet number, weight and water content were increased in the fig-treated groups as compared to the control group. Reductions in body weight and increased intestinal transit length were observed in the fig-treated groups. Fecal pellet number was reduced in the distal colons of the fig-treated rats. Exercise and ileum tension increased in the experimental groups as compared to the control group. According to histological analyses, the thickness of the distal colon and areas of crypt epithelial cells that produce mucin were increased in the fig-treated groups in a dose-dependent manner. CONCLUSION: Constipation was decreased when fig fruit was fed to rats. Specifically, fecal number, weight, and water content, as well as histological parameters such as thickness and mucin areas in the distal colon were improved. Fig treatment may be a useful therapeutic and preventive strategy for chronic constipation. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/22178225/Effects_of_Ficus_carica_paste_on_loperamide_induced_constipation_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(11)00654-5 DB - PRIME DP - Unbound Medicine ER -