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Role of peroxisomes in ROS/RNS-metabolism: implications for human disease.
Biochim Biophys Acta. 2012 Sep; 1822(9):1363-73.BB

Abstract

Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same time, these organelles generate reactive oxygen and nitrogen species as byproducts. Peroxisomes also possess intricate protective mechanisms to counteract oxidative stress and maintain redox balance. An imbalance between peroxisomal reactive oxygen species/reactive nitrogen species production and removal may possibly damage biomolecules, perturb cellular thiol levels, and deregulate cellular signaling pathways implicated in a variety of human diseases. Somewhat surprisingly, the potential role of peroxisomes in cellular redox metabolism has been underestimated for a long time. However, in recent years, peroxisomal reactive oxygen species/reactive nitrogen species metabolism and signaling have become the focus of a rapidly evolving and multidisciplinary research field with great prospects. This review is mainly devoted to discuss evidence supporting the notion that peroxisomal metabolism and oxidative stress are intimately interconnected and associated with age-related diseases. We focus on several key aspects of how peroxisomes contribute to cellular reactive oxygen species/reactive nitrogen species levels in mammalian cells and how these cells cope with peroxisome-derived oxidative stress. We also provide a brief overview of recent strategies that have been successfully employed to detect and modulate the peroxisomal redox status. Finally, we highlight some gaps in our knowledge and propose potential avenues for further research. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of peroxisomes in Health and Disease.

Authors+Show Affiliations

Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium. marc.fransen@med.kuleuven.beNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22178243

Citation

Fransen, Marc, et al. "Role of Peroxisomes in ROS/RNS-metabolism: Implications for Human Disease." Biochimica Et Biophysica Acta, vol. 1822, no. 9, 2012, pp. 1363-73.
Fransen M, Nordgren M, Wang B, et al. Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochim Biophys Acta. 2012;1822(9):1363-73.
Fransen, M., Nordgren, M., Wang, B., & Apanasets, O. (2012). Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochimica Et Biophysica Acta, 1822(9), 1363-73. https://doi.org/10.1016/j.bbadis.2011.12.001
Fransen M, et al. Role of Peroxisomes in ROS/RNS-metabolism: Implications for Human Disease. Biochim Biophys Acta. 2012;1822(9):1363-73. PubMed PMID: 22178243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. AU - Fransen,Marc, AU - Nordgren,Marcus, AU - Wang,Bo, AU - Apanasets,Oksana, Y1 - 2011/12/09/ PY - 2011/09/30/received PY - 2011/11/25/revised PY - 2011/12/02/accepted PY - 2011/12/20/entrez PY - 2011/12/20/pubmed PY - 2013/2/16/medline SP - 1363 EP - 73 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 1822 IS - 9 N2 - Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same time, these organelles generate reactive oxygen and nitrogen species as byproducts. Peroxisomes also possess intricate protective mechanisms to counteract oxidative stress and maintain redox balance. An imbalance between peroxisomal reactive oxygen species/reactive nitrogen species production and removal may possibly damage biomolecules, perturb cellular thiol levels, and deregulate cellular signaling pathways implicated in a variety of human diseases. Somewhat surprisingly, the potential role of peroxisomes in cellular redox metabolism has been underestimated for a long time. However, in recent years, peroxisomal reactive oxygen species/reactive nitrogen species metabolism and signaling have become the focus of a rapidly evolving and multidisciplinary research field with great prospects. This review is mainly devoted to discuss evidence supporting the notion that peroxisomal metabolism and oxidative stress are intimately interconnected and associated with age-related diseases. We focus on several key aspects of how peroxisomes contribute to cellular reactive oxygen species/reactive nitrogen species levels in mammalian cells and how these cells cope with peroxisome-derived oxidative stress. We also provide a brief overview of recent strategies that have been successfully employed to detect and modulate the peroxisomal redox status. Finally, we highlight some gaps in our knowledge and propose potential avenues for further research. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of peroxisomes in Health and Disease. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/22178243/Role_of_peroxisomes_in_ROS/RNS_metabolism:_implications_for_human_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4439(11)00279-1 DB - PRIME DP - Unbound Medicine ER -