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Increased FGFR1 copy number in lung squamous cell carcinomas.
Mol Med Rep. 2012 Mar; 5(3):725-8.MM

Abstract

The basic fibroblast growth factor (bFGF), via activation of its receptor, FGFR1, has been postulated to be an important inducer of host stromal response and angiogenesis. More recently, FGFR1 amplifications were investigated using large-scale single nucleotide polymorphism arrays in lung cancer. We hypothesized that FGFR1 overexpression may be correlated with the clinicopathological features of lung cancers. The increased copy number of the FGFR1 gene was analyzed by real-time polymerase chain reaction amplifications in 100 surgically treated non-small cell lung cancer cases from Nagoya City University Hospital. Sixty-five squamous cell carcinoma cases were included. An increased FGFR1 gene copy number was found in 32 (32%) lung cancer patients. The increased FGFR1 copy number status significantly correlated with gender (females 13.8% vs. males 39.4%, p=0.0173), smoking status (never smoker 4.2% vs. smoker 40.8%, p=0.0004) and pathological subtypes (squamous cell carcinoma 41.5% vs. non-squamous cell carcinoma 14.3%, p=0.0066). However, within the squamous cell carcinomas the FGFR1 copy number status did not significantly correlate with gender, smoking status, pathological stages and differentiation status of the lung cancers. Thus, the FGFR1 copy number is common within squamous cell carcinoma.

Authors+Show Affiliations

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. hisasaki@med.nagoya-cu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22179561

Citation

Sasaki, Hidefumi, et al. "Increased FGFR1 Copy Number in Lung Squamous Cell Carcinomas." Molecular Medicine Reports, vol. 5, no. 3, 2012, pp. 725-8.
Sasaki H, Shitara M, Yokota K, et al. Increased FGFR1 copy number in lung squamous cell carcinomas. Mol Med Rep. 2012;5(3):725-8.
Sasaki, H., Shitara, M., Yokota, K., Hikosaka, Y., Moriyama, S., Yano, M., & Fujii, Y. (2012). Increased FGFR1 copy number in lung squamous cell carcinomas. Molecular Medicine Reports, 5(3), 725-8. https://doi.org/10.3892/mmr.2011.715
Sasaki H, et al. Increased FGFR1 Copy Number in Lung Squamous Cell Carcinomas. Mol Med Rep. 2012;5(3):725-8. PubMed PMID: 22179561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased FGFR1 copy number in lung squamous cell carcinomas. AU - Sasaki,Hidefumi, AU - Shitara,Masayuki, AU - Yokota,Keisuke, AU - Hikosaka,Yu, AU - Moriyama,Satoru, AU - Yano,Motoki, AU - Fujii,Yoshitaka, Y1 - 2011/12/15/ PY - 2011/08/17/received PY - 2011/12/09/accepted PY - 2011/12/20/entrez PY - 2011/12/20/pubmed PY - 2012/5/4/medline SP - 725 EP - 8 JF - Molecular medicine reports JO - Mol Med Rep VL - 5 IS - 3 N2 - The basic fibroblast growth factor (bFGF), via activation of its receptor, FGFR1, has been postulated to be an important inducer of host stromal response and angiogenesis. More recently, FGFR1 amplifications were investigated using large-scale single nucleotide polymorphism arrays in lung cancer. We hypothesized that FGFR1 overexpression may be correlated with the clinicopathological features of lung cancers. The increased copy number of the FGFR1 gene was analyzed by real-time polymerase chain reaction amplifications in 100 surgically treated non-small cell lung cancer cases from Nagoya City University Hospital. Sixty-five squamous cell carcinoma cases were included. An increased FGFR1 gene copy number was found in 32 (32%) lung cancer patients. The increased FGFR1 copy number status significantly correlated with gender (females 13.8% vs. males 39.4%, p=0.0173), smoking status (never smoker 4.2% vs. smoker 40.8%, p=0.0004) and pathological subtypes (squamous cell carcinoma 41.5% vs. non-squamous cell carcinoma 14.3%, p=0.0066). However, within the squamous cell carcinomas the FGFR1 copy number status did not significantly correlate with gender, smoking status, pathological stages and differentiation status of the lung cancers. Thus, the FGFR1 copy number is common within squamous cell carcinoma. SN - 1791-3004 UR - https://www.unboundmedicine.com/medline/citation/22179561/Increased_FGFR1_copy_number_in_lung_squamous_cell_carcinomas_ L2 - http://www.spandidos-publications.com/mmr/5/3/725 DB - PRIME DP - Unbound Medicine ER -