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Dorsal versus ventral hippocampal contributions to trace and contextual conditioning: differential effects of regionally selective NMDA receptor antagonism on acquisition and expression.
Hippocampus. 2012 Jul; 22(7):1528-39.H

Abstract

The dorsal and ventral subregions of the hippocampus likely play dissociable roles in some forms of learning. For example, we have previously demonstrated that temporary inactivation of ventral, but not dorsal, hippocampus dramatically impaired the acquisition of trace fear conditioning, while temporary inactivation of dorsal, but not ventral, hippocampus impaired spatially guided reinforced alternation (Czerniawski et al. (2009) Hippocampus 19:20-32). Importantly, emerging data suggest that lesions, temporary inactivation, and NMDA receptor antagonism within these subregions can produce quite different patterns of behavioral effects when administered into the same region. Specifically, while neither lesions nor temporary inactivation of dorsal hippocampus impair the acquisition of trace fear conditioning, learning in this paradigm is severely impaired by pre-training administration of the NMDA receptor antagonist dl-2-phosphonovaleric acid (APV) in dorsal hippocampus; the effect of NMDA receptor antagonism within ventral hippocampus on the acquisition and expression of trace conditioning, or on learning in general, has not yet been systematically explored. The present study extends our previous work examining the differential effect of lesions or inactivation of the dorsal and ventral hippocampal subregions by systematically examining the effect of regionally selective pre-training or pre-testing administration of APV on the acquisition and expression of trace and contextual fear conditioning. The results of these studies demonstrate that while pre-training NMDA receptor antagonism within either the dorsal or ventral subregion of the hippocampus impaired the acquisition of both trace and contextual conditioning, pre-testing NMDA receptor antagonism within ventral, but not dorsal, hippocampus impaired the expression of previously-acquired trace and contextual fear conditioning. These data suggest that selectively manipulating the integrity of individual subregions may result in compensatory mechanisms that can support learning, and that NMDA-dependent plasticity within both dorsal and ventral hippocampus is normally required for the acquisition and maintenance of memory in trace and contextual fear conditioning.

Authors+Show Affiliations

Department of Psychology, Rutgers University, New Brunswick, NJ 08854, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22180082

Citation

Czerniawski, Jennifer, et al. "Dorsal Versus Ventral Hippocampal Contributions to Trace and Contextual Conditioning: Differential Effects of Regionally Selective NMDA Receptor Antagonism On Acquisition and Expression." Hippocampus, vol. 22, no. 7, 2012, pp. 1528-39.
Czerniawski J, Ree F, Chia C, et al. Dorsal versus ventral hippocampal contributions to trace and contextual conditioning: differential effects of regionally selective NMDA receptor antagonism on acquisition and expression. Hippocampus. 2012;22(7):1528-39.
Czerniawski, J., Ree, F., Chia, C., & Otto, T. (2012). Dorsal versus ventral hippocampal contributions to trace and contextual conditioning: differential effects of regionally selective NMDA receptor antagonism on acquisition and expression. Hippocampus, 22(7), 1528-39. https://doi.org/10.1002/hipo.20992
Czerniawski J, et al. Dorsal Versus Ventral Hippocampal Contributions to Trace and Contextual Conditioning: Differential Effects of Regionally Selective NMDA Receptor Antagonism On Acquisition and Expression. Hippocampus. 2012;22(7):1528-39. PubMed PMID: 22180082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsal versus ventral hippocampal contributions to trace and contextual conditioning: differential effects of regionally selective NMDA receptor antagonism on acquisition and expression. AU - Czerniawski,Jennifer, AU - Ree,Fredrick, AU - Chia,Chester, AU - Otto,Tim, Y1 - 2011/12/19/ PY - 2011/10/13/accepted PY - 2011/12/20/entrez PY - 2011/12/20/pubmed PY - 2013/1/16/medline SP - 1528 EP - 39 JF - Hippocampus JO - Hippocampus VL - 22 IS - 7 N2 - The dorsal and ventral subregions of the hippocampus likely play dissociable roles in some forms of learning. For example, we have previously demonstrated that temporary inactivation of ventral, but not dorsal, hippocampus dramatically impaired the acquisition of trace fear conditioning, while temporary inactivation of dorsal, but not ventral, hippocampus impaired spatially guided reinforced alternation (Czerniawski et al. (2009) Hippocampus 19:20-32). Importantly, emerging data suggest that lesions, temporary inactivation, and NMDA receptor antagonism within these subregions can produce quite different patterns of behavioral effects when administered into the same region. Specifically, while neither lesions nor temporary inactivation of dorsal hippocampus impair the acquisition of trace fear conditioning, learning in this paradigm is severely impaired by pre-training administration of the NMDA receptor antagonist dl-2-phosphonovaleric acid (APV) in dorsal hippocampus; the effect of NMDA receptor antagonism within ventral hippocampus on the acquisition and expression of trace conditioning, or on learning in general, has not yet been systematically explored. The present study extends our previous work examining the differential effect of lesions or inactivation of the dorsal and ventral hippocampal subregions by systematically examining the effect of regionally selective pre-training or pre-testing administration of APV on the acquisition and expression of trace and contextual fear conditioning. The results of these studies demonstrate that while pre-training NMDA receptor antagonism within either the dorsal or ventral subregion of the hippocampus impaired the acquisition of both trace and contextual conditioning, pre-testing NMDA receptor antagonism within ventral, but not dorsal, hippocampus impaired the expression of previously-acquired trace and contextual fear conditioning. These data suggest that selectively manipulating the integrity of individual subregions may result in compensatory mechanisms that can support learning, and that NMDA-dependent plasticity within both dorsal and ventral hippocampus is normally required for the acquisition and maintenance of memory in trace and contextual fear conditioning. SN - 1098-1063 UR - https://www.unboundmedicine.com/medline/citation/22180082/Dorsal_versus_ventral_hippocampal_contributions_to_trace_and_contextual_conditioning:_differential_effects_of_regionally_selective_NMDA_receptor_antagonism_on_acquisition_and_expression_ L2 - https://doi.org/10.1002/hipo.20992 DB - PRIME DP - Unbound Medicine ER -