Tags

Type your tag names separated by a space and hit enter

Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution.
J Investig Clin Dent 2012; 3(2):98-102JI

Abstract

AIM

The aim of this retrospective study was to evaluate the outcome of medical treatment of classic trigeminal neuralgia and to assess the factors affecting the choice of drug regimen (single or multiple), and the duration of treatment for pain control.

METHODS

A total of 260 consecutive patients were included in the study. Sixty-one patients with less than 6 months' follow up were excluded. All patients were treated with carbamazepine alone or in combination with other drugs. The dosage was adjusted according to the level of pain control and side-effects.

RESULTS

Treatment was terminated in 99 patients (49.7%) after a mean follow-up period of 36.46 months (standard deviation: ±26.5). Of these, 39.4% were on a single drug. Carbamazepine was the drug used in 36 patients. The rest (61%) needed various combinations of drugs. One-hundred patients (50.3%) continued with medical treatment during the follow-up period. Of these, 67.4% were on multi-drug therapy.

CONCLUSION

The present study showed that the administration of multidrug regimens is a useful alternative in controlling trigeminal neuralgia in patients who are unable to tolerate higher doses of carbamazepine. Age, sex, ethnicity, and the side of affliction did not have a significant influence on the choice of drug regimen and the duration of treatment for pain control.

Authors+Show Affiliations

Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. spaga@pdn.ac.lkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22180190

Citation

Ariyawardana, Anura, et al. "Use of Single- and Multi-drug Regimens in the Management of Classic (idiopathic) Trigeminal Neuralgia: an 11-year Experience at a Single Sri Lankan Institution." Journal of Investigative and Clinical Dentistry, vol. 3, no. 2, 2012, pp. 98-102.
Ariyawardana A, Pallegama R, Sitheeque M, et al. Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution. J Investig Clin Dent. 2012;3(2):98-102.
Ariyawardana, A., Pallegama, R., Sitheeque, M., & Ranasinghe, A. (2012). Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution. Journal of Investigative and Clinical Dentistry, 3(2), pp. 98-102. doi:10.1111/j.2041-1626.2011.00109.x.
Ariyawardana A, et al. Use of Single- and Multi-drug Regimens in the Management of Classic (idiopathic) Trigeminal Neuralgia: an 11-year Experience at a Single Sri Lankan Institution. J Investig Clin Dent. 2012;3(2):98-102. PubMed PMID: 22180190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution. AU - Ariyawardana,Anura, AU - Pallegama,Ranjith, AU - Sitheeque,Mohaideen, AU - Ranasinghe,Ajith, Y1 - 2011/12/19/ PY - 2011/12/20/entrez PY - 2011/12/20/pubmed PY - 2013/4/17/medline SP - 98 EP - 102 JF - Journal of investigative and clinical dentistry JO - J Investig Clin Dent VL - 3 IS - 2 N2 - AIM: The aim of this retrospective study was to evaluate the outcome of medical treatment of classic trigeminal neuralgia and to assess the factors affecting the choice of drug regimen (single or multiple), and the duration of treatment for pain control. METHODS: A total of 260 consecutive patients were included in the study. Sixty-one patients with less than 6 months' follow up were excluded. All patients were treated with carbamazepine alone or in combination with other drugs. The dosage was adjusted according to the level of pain control and side-effects. RESULTS: Treatment was terminated in 99 patients (49.7%) after a mean follow-up period of 36.46 months (standard deviation: ±26.5). Of these, 39.4% were on a single drug. Carbamazepine was the drug used in 36 patients. The rest (61%) needed various combinations of drugs. One-hundred patients (50.3%) continued with medical treatment during the follow-up period. Of these, 67.4% were on multi-drug therapy. CONCLUSION: The present study showed that the administration of multidrug regimens is a useful alternative in controlling trigeminal neuralgia in patients who are unable to tolerate higher doses of carbamazepine. Age, sex, ethnicity, and the side of affliction did not have a significant influence on the choice of drug regimen and the duration of treatment for pain control. SN - 2041-1626 UR - https://www.unboundmedicine.com/medline/citation/22180190/Use_of_single__and_multi_drug_regimens_in_the_management_of_classic__idiopathic__trigeminal_neuralgia:_an_11_year_experience_at_a_single_Sri_Lankan_institution_ L2 - https://doi.org/10.1111/j.2041-1626.2011.00109.x DB - PRIME DP - Unbound Medicine ER -