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The value of fine needle aspiration biopsy in the diagnosis and prognostic assessment of palpable breast lesions.
Diagn Cytopathol. 2012 Jan; 40(1):26-34.DC

Abstract

In recent years there appears to be a growing movement toward the use of core needle biopsy (CNB) over fine needle aspiration biopsy (FNAB) for the detection of breast carcinoma. This tendency is caused in part by the idea that CNB can provide a more specific or definitive diagnosis as well as the belief that the assessment of prognostic/predictive factor is not possible or reliable on cytologic specimens. At our institution, FNAB of breast has been practiced for over 25 years with excellent cytologic-histological correlation. This practice has been beneficial not only for patients, but also for training physicians since nowadays a very small number of centers in the United States still routinely perform fine needle aspiration as a diagnostic tool in breast cases. To assess the diagnostic accuracy of FNAB in palpable breast lesions, we reviewed our experience during an 8-year-period and compared fine needle aspiration results with follow-up surgical specimens. From the cytology point of view, the lesions were divided as negative/benign, atypical/suspicious, positive, and insufficient. Only cases performed by pathologists were included. A total of 1,583 cases were retrieved from our archives. A definitive malignant diagnosis was reached in 357 cases. One-hundred and thirty-nine cases were classified as atypical/ suspicious, 135 cases had insufficient cells for establishing a diagnosis, and 952 were categorized as negative. A total of 408 follow-up surgical specimens were available for comparison with cytologic results. There were 19 false-negative, and no false-positive results were found. The majority of false-negative results were secondary to sampling errors. In 93% of the malignant cases, there was enough material obtained in cytological specimens to perform prognostic/predictive factors studies. Our data proves once again that FNAB is a reliable method for the initial evaluation and diagnosis of palpable masses of the breast. In addition, it also has the ability of providing necessary prognostic/predictive information, particularly for patients that may undergo neoadjuvant therapy.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, University of Florida, College of Medicine, Jacksonville, Florida 32209, USA. marilin.rosa@jax.ufl.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22180235

Citation

Rosa, Marilin, et al. "The Value of Fine Needle Aspiration Biopsy in the Diagnosis and Prognostic Assessment of Palpable Breast Lesions." Diagnostic Cytopathology, vol. 40, no. 1, 2012, pp. 26-34.
Rosa M, Mohammadi A, Masood S. The value of fine needle aspiration biopsy in the diagnosis and prognostic assessment of palpable breast lesions. Diagn Cytopathol. 2012;40(1):26-34.
Rosa, M., Mohammadi, A., & Masood, S. (2012). The value of fine needle aspiration biopsy in the diagnosis and prognostic assessment of palpable breast lesions. Diagnostic Cytopathology, 40(1), 26-34. https://doi.org/10.1002/dc.21497
Rosa M, Mohammadi A, Masood S. The Value of Fine Needle Aspiration Biopsy in the Diagnosis and Prognostic Assessment of Palpable Breast Lesions. Diagn Cytopathol. 2012;40(1):26-34. PubMed PMID: 22180235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The value of fine needle aspiration biopsy in the diagnosis and prognostic assessment of palpable breast lesions. AU - Rosa,Marilin, AU - Mohammadi,Amir, AU - Masood,Shahla, Y1 - 2010/11/02/ PY - 2010/05/07/received PY - 2010/06/10/accepted PY - 2011/12/20/entrez PY - 2011/12/20/pubmed PY - 2012/4/5/medline SP - 26 EP - 34 JF - Diagnostic cytopathology JO - Diagn Cytopathol VL - 40 IS - 1 N2 - In recent years there appears to be a growing movement toward the use of core needle biopsy (CNB) over fine needle aspiration biopsy (FNAB) for the detection of breast carcinoma. This tendency is caused in part by the idea that CNB can provide a more specific or definitive diagnosis as well as the belief that the assessment of prognostic/predictive factor is not possible or reliable on cytologic specimens. At our institution, FNAB of breast has been practiced for over 25 years with excellent cytologic-histological correlation. This practice has been beneficial not only for patients, but also for training physicians since nowadays a very small number of centers in the United States still routinely perform fine needle aspiration as a diagnostic tool in breast cases. To assess the diagnostic accuracy of FNAB in palpable breast lesions, we reviewed our experience during an 8-year-period and compared fine needle aspiration results with follow-up surgical specimens. From the cytology point of view, the lesions were divided as negative/benign, atypical/suspicious, positive, and insufficient. Only cases performed by pathologists were included. A total of 1,583 cases were retrieved from our archives. A definitive malignant diagnosis was reached in 357 cases. One-hundred and thirty-nine cases were classified as atypical/ suspicious, 135 cases had insufficient cells for establishing a diagnosis, and 952 were categorized as negative. A total of 408 follow-up surgical specimens were available for comparison with cytologic results. There were 19 false-negative, and no false-positive results were found. The majority of false-negative results were secondary to sampling errors. In 93% of the malignant cases, there was enough material obtained in cytological specimens to perform prognostic/predictive factors studies. Our data proves once again that FNAB is a reliable method for the initial evaluation and diagnosis of palpable masses of the breast. In addition, it also has the ability of providing necessary prognostic/predictive information, particularly for patients that may undergo neoadjuvant therapy. SN - 1097-0339 UR - https://www.unboundmedicine.com/medline/citation/22180235/The_value_of_fine_needle_aspiration_biopsy_in_the_diagnosis_and_prognostic_assessment_of_palpable_breast_lesions_ L2 - https://doi.org/10.1002/dc.21497 DB - PRIME DP - Unbound Medicine ER -