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SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission.
Curr Opin Virol. 2011 Dec; 1(6):624-34.CO

Abstract

Most new emerging viruses are derived from strains circulating in zoonotic reservoirs. Coronaviruses, which had an established potential for cross-species transmission within domesticated animals, suddenly became relevant with the unexpected emergence of the highly pathogenic human SARS-CoV strain from zoonotic reservoirs in 2002. SARS-CoV infected approximately 8000 people worldwide before public health measures halted the epidemic. Supported by robust time-ordered sequence variation, structural biology, well-characterized patient pools, and biological data, the emergence of SARS-CoV represents one of the best-studied natural models of viral disease emergence from zoonotic sources. This review article summarizes previous and more recent advances into the molecular and structural characteristics, with particular emphasis on host–receptor interactions, that drove this remarkable virus disease outbreak in human populations.

Authors+Show Affiliations

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

22180768

Citation

Bolles, Meagan, et al. "SARS-CoV and Emergent Coronaviruses: Viral Determinants of Interspecies Transmission." Current Opinion in Virology, vol. 1, no. 6, 2011, pp. 624-34.
Bolles M, Donaldson E, Baric R. SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission. Curr Opin Virol. 2011;1(6):624-34.
Bolles, M., Donaldson, E., & Baric, R. (2011). SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission. Current Opinion in Virology, 1(6), 624-34. https://doi.org/10.1016/j.coviro.2011.10.012
Bolles M, Donaldson E, Baric R. SARS-CoV and Emergent Coronaviruses: Viral Determinants of Interspecies Transmission. Curr Opin Virol. 2011;1(6):624-34. PubMed PMID: 22180768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission. AU - Bolles,Meagan, AU - Donaldson,Eric, AU - Baric,Ralph, PY - 2011/12/20/entrez PY - 2011/12/20/pubmed PY - 2012/12/10/medline SP - 624 EP - 34 JF - Current opinion in virology JO - Curr Opin Virol VL - 1 IS - 6 N2 - Most new emerging viruses are derived from strains circulating in zoonotic reservoirs. Coronaviruses, which had an established potential for cross-species transmission within domesticated animals, suddenly became relevant with the unexpected emergence of the highly pathogenic human SARS-CoV strain from zoonotic reservoirs in 2002. SARS-CoV infected approximately 8000 people worldwide before public health measures halted the epidemic. Supported by robust time-ordered sequence variation, structural biology, well-characterized patient pools, and biological data, the emergence of SARS-CoV represents one of the best-studied natural models of viral disease emergence from zoonotic sources. This review article summarizes previous and more recent advances into the molecular and structural characteristics, with particular emphasis on host–receptor interactions, that drove this remarkable virus disease outbreak in human populations. SN - 1879-6265 UR - https://www.unboundmedicine.com/medline/citation/22180768/SARS_CoV_and_emergent_coronaviruses:_viral_determinants_of_interspecies_transmission_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1879-6257(11)00131-3 DB - PRIME DP - Unbound Medicine ER -