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Relationships among interleukin-6, tumor necrosis factor-α, adipokines, vitamin D, and chronic periodontitis.
J Periodontol. 2012 Sep; 83(9):1183-91.JP

Abstract

BACKGROUND

The aim of this study is to explore relationships among serum adipokines, vitamin D, and clinical and microbial parameters of chronic periodontitis before and after treatment.

METHODS

Weight, height, and smoking status were recorded for 56 patients with chronic periodontitis. Plaque, gingivitis, bleeding on probing, suppuration, probing depth, and clinical attachment level were measured at all teeth present. Subgingival biofilm samples from each tooth were analyzed for levels of 40 bacterial species using checkerboard DNA-DNA hybridization. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-α, adiponectin, leptin, resistin, and vitamin D were measured at baseline. Sample collection was then performed in a subset of the population 6 months after therapy (n = 17). Serum samples were analyzed using enzyme-linked immunosorbent assay and immunoassays. Differences in clinical, microbial, and serum factors among groups were sought using the Mann-Whitney U test. Correlations among factors were evaluated using regression analysis. Effects of therapy were sought using the Wilcoxon signed rank test.

RESULTS

There were positive correlations between adiponectin/vitamin D and between IL-6/leptin, negative correlations between IL-6/vitamin D and leptin/vitamin D, but no associations between serum analytes and clinical or microbial parameters. Sex and body mass index were associated with levels of adipokines. Periodontal therapy improved clinical and microbiologic parameters but did not influence the levels of serum analytes.

CONCLUSION

Adipokines and IL-6 levels were affected by sex and body mass index. Serum analytes were not influenced by periodontal therapy.

Authors+Show Affiliations

Department of Periodontology, The Forsyth Institute, Cambridge, MA 02142, USA. fteles@forsyth.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22181684

Citation

Teles, Flavia R., et al. "Relationships Among Interleukin-6, Tumor Necrosis Factor-α, Adipokines, Vitamin D, and Chronic Periodontitis." Journal of Periodontology, vol. 83, no. 9, 2012, pp. 1183-91.
Teles FR, Teles RP, Martin L, et al. Relationships among interleukin-6, tumor necrosis factor-α, adipokines, vitamin D, and chronic periodontitis. J Periodontol. 2012;83(9):1183-91.
Teles, F. R., Teles, R. P., Martin, L., Socransky, S. S., & Haffajee, A. D. (2012). Relationships among interleukin-6, tumor necrosis factor-α, adipokines, vitamin D, and chronic periodontitis. Journal of Periodontology, 83(9), 1183-91. https://doi.org/10.1902/jop.2011.110346
Teles FR, et al. Relationships Among Interleukin-6, Tumor Necrosis Factor-α, Adipokines, Vitamin D, and Chronic Periodontitis. J Periodontol. 2012;83(9):1183-91. PubMed PMID: 22181684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships among interleukin-6, tumor necrosis factor-α, adipokines, vitamin D, and chronic periodontitis. AU - Teles,Flavia R, AU - Teles,Ricardo P, AU - Martin,Lynn, AU - Socransky,Sigmund S, AU - Haffajee,Anne D, Y1 - 2011/12/19/ PY - 2011/12/21/entrez PY - 2011/12/21/pubmed PY - 2013/2/13/medline SP - 1183 EP - 91 JF - Journal of periodontology JO - J. Periodontol. VL - 83 IS - 9 N2 - BACKGROUND: The aim of this study is to explore relationships among serum adipokines, vitamin D, and clinical and microbial parameters of chronic periodontitis before and after treatment. METHODS: Weight, height, and smoking status were recorded for 56 patients with chronic periodontitis. Plaque, gingivitis, bleeding on probing, suppuration, probing depth, and clinical attachment level were measured at all teeth present. Subgingival biofilm samples from each tooth were analyzed for levels of 40 bacterial species using checkerboard DNA-DNA hybridization. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-α, adiponectin, leptin, resistin, and vitamin D were measured at baseline. Sample collection was then performed in a subset of the population 6 months after therapy (n = 17). Serum samples were analyzed using enzyme-linked immunosorbent assay and immunoassays. Differences in clinical, microbial, and serum factors among groups were sought using the Mann-Whitney U test. Correlations among factors were evaluated using regression analysis. Effects of therapy were sought using the Wilcoxon signed rank test. RESULTS: There were positive correlations between adiponectin/vitamin D and between IL-6/leptin, negative correlations between IL-6/vitamin D and leptin/vitamin D, but no associations between serum analytes and clinical or microbial parameters. Sex and body mass index were associated with levels of adipokines. Periodontal therapy improved clinical and microbiologic parameters but did not influence the levels of serum analytes. CONCLUSION: Adipokines and IL-6 levels were affected by sex and body mass index. Serum analytes were not influenced by periodontal therapy. SN - 1943-3670 UR - https://www.unboundmedicine.com/medline/citation/22181684/Relationships_among_interleukin_6_tumor_necrosis_factor_α_adipokines_vitamin_D_and_chronic_periodontitis_ L2 - https://doi.org/10.1902/jop.2011.110346 DB - PRIME DP - Unbound Medicine ER -