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Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.
Neuropharmacology 2012; 62(4):1777-86N

Abstract

Numerous rodent and human studies have demonstrated that neuropeptide Y (NPY) is involved in the regulation of anxiety-related behaviors. In this study, we examined whether there were differences in NPY signaling between two inbred mouse strains (C57BL/6J and DBA/2J) that exhibit divergent basal and stress-induced anxiety phenotypes. We focused on the bed nucleus of the stria terminals (BNST), a structure in the extended amygdala that is important for the regulation of anxiety-like behavior and contains NPY receptors. While results from whole-cell voltage-clamp recordings and immunofluorescence histochemistry revealed no significant basal differences in NPY signaling or NPY and NPY Y2 receptor (Y2R) expression in the BNST, these measures were differentially altered by chronic restraint stress. Ten days of chronic restraint stress increased basal GABAergic transmission and decreased NPY's ability to inhibit evoked GABAergic transmission in the dorsolateral BNST (dlBNST) via Y2R in DBA/2J, but not C57BL/6J, mice. Additionally, restraint stress increased NPY and Y2R expression across subregions of the BNST of DBA/2J mice 24 h after the last stress exposure, but no changes were observed in C57BL/6J mice. Together, these results suggest that chronic restraint stress engages the NPY system and alters NPY modulation of inhibitory transmission in the dlBNST of DBA/2J mice, but not C57BL/6J mice, which may be related to increased expression of anxiety-related behaviors in this strain.

Authors+Show Affiliations

Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina Chapel Hill, 104 Manning Driv, Chapel Hill, NC 27599, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22182779

Citation

Pleil, Kristen E., et al. "Chronic Stress Alters Neuropeptide Y Signaling in the Bed Nucleus of the Stria Terminalis in DBA/2J but Not C57BL/6J Mice." Neuropharmacology, vol. 62, no. 4, 2012, pp. 1777-86.
Pleil KE, Lopez A, McCall N, et al. Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology. 2012;62(4):1777-86.
Pleil, K. E., Lopez, A., McCall, N., Jijon, A. M., Bravo, J. P., & Kash, T. L. (2012). Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology, 62(4), pp. 1777-86. doi:10.1016/j.neuropharm.2011.12.002.
Pleil KE, et al. Chronic Stress Alters Neuropeptide Y Signaling in the Bed Nucleus of the Stria Terminalis in DBA/2J but Not C57BL/6J Mice. Neuropharmacology. 2012;62(4):1777-86. PubMed PMID: 22182779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. AU - Pleil,Kristen E, AU - Lopez,Alberto, AU - McCall,Nora, AU - Jijon,Ana M, AU - Bravo,Jose Peña, AU - Kash,Thomas L, Y1 - 2011/12/09/ PY - 2011/08/18/received PY - 2011/11/30/revised PY - 2011/12/01/accepted PY - 2011/12/21/entrez PY - 2011/12/21/pubmed PY - 2012/7/28/medline SP - 1777 EP - 86 JF - Neuropharmacology JO - Neuropharmacology VL - 62 IS - 4 N2 - Numerous rodent and human studies have demonstrated that neuropeptide Y (NPY) is involved in the regulation of anxiety-related behaviors. In this study, we examined whether there were differences in NPY signaling between two inbred mouse strains (C57BL/6J and DBA/2J) that exhibit divergent basal and stress-induced anxiety phenotypes. We focused on the bed nucleus of the stria terminals (BNST), a structure in the extended amygdala that is important for the regulation of anxiety-like behavior and contains NPY receptors. While results from whole-cell voltage-clamp recordings and immunofluorescence histochemistry revealed no significant basal differences in NPY signaling or NPY and NPY Y2 receptor (Y2R) expression in the BNST, these measures were differentially altered by chronic restraint stress. Ten days of chronic restraint stress increased basal GABAergic transmission and decreased NPY's ability to inhibit evoked GABAergic transmission in the dorsolateral BNST (dlBNST) via Y2R in DBA/2J, but not C57BL/6J, mice. Additionally, restraint stress increased NPY and Y2R expression across subregions of the BNST of DBA/2J mice 24 h after the last stress exposure, but no changes were observed in C57BL/6J mice. Together, these results suggest that chronic restraint stress engages the NPY system and alters NPY modulation of inhibitory transmission in the dlBNST of DBA/2J mice, but not C57BL/6J mice, which may be related to increased expression of anxiety-related behaviors in this strain. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/22182779/Chronic_stress_alters_neuropeptide_Y_signaling_in_the_bed_nucleus_of_the_stria_terminalis_in_DBA/2J_but_not_C57BL/6J_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(11)00503-X DB - PRIME DP - Unbound Medicine ER -