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Fruit, vegetables, fibre and micronutrients and risk of US renal cell carcinoma.

Abstract

The association between renal cell cancer (RCC) and intake of fruit, vegetables and nutrients was examined in a population-based case-control study of 323 cases and 1827 controls; dietary intake was obtained using a mailed questionnaire. Cancer risks were estimated by OR and 95 % CI, adjusting for age, sex, smoking, obesity, hypertension, proxy status, alcohol consumption and dietary fat intake and energy. Intake of vegetables was associated with a decreased risk of RCC (OR 0·5; 95 % CI 0·3, 0·7; P trend = 0·002), (top compared to the bottom quartile of intake). When intake of individual nutrients was investigated, vegetable fibre intake was associated with decreased risks (OR 0·4; 95 % CI 0·2, 0·6; P < 0·001), but this was not the case with fruit fibre (OR 0·7; 95 % CI 0·4, 1·1) or grain fibre (OR 1·0; 95 % CI 0·6, 1·5). β-Cryptoxanthin and lycopene were also associated with decreased risks, but when both were included in a mutually adjusted backwards stepwise regression model, only β-cryptoxanthin remained significant (OR 0·5; 95 % CI 0·3, 0·8). When other micronutrients and types of fibre were investigated together, only vegetable fibre and β-cryptoxanthin had significant trends (P < 0·01) (OR 0·6; 95 % CI 0·3, 0·9) (OR 0·5; 95 % CI 0·3, 0·9), respectively. These findings were stronger in those aged over 65 years (P interaction = 0·001). Among non-smokers, low intake of cruciferous vegetables and fruit fibre was also associated with increased risk of RCC (P interaction = 0·03); similar inverse associations were found for β-cryptoxanthin, lycopene and vitamin C. When nutrients were mutually adjusted by backwards regression in these subgroups, only β-cryptoxanthin remained associated with lower RCC risk. These findings deserve further investigation in ongoing prospective studies when sample size becomes sufficient.

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  • Authors+Show Affiliations

    ,

    Department of Behavioural and Social Sciences, Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia. kaye.brock@sydney.edu.au

    , , , , , ,

    Source

    The British journal of nutrition 108:6 2012 Sep 28 pg 1077-85

    MeSH

    Adult
    Age Factors
    Aged
    Aged, 80 and over
    Carcinoma, Renal Cell
    Case-Control Studies
    Cryptoxanthins
    Diet
    Dietary Fiber
    Edible Grain
    Female
    Fruit
    Humans
    Iowa
    Kidney Neoplasms
    Male
    Micronutrients
    Middle Aged
    Nutrition Surveys
    Registries
    Risk Factors
    Vegetables
    Xanthophylls

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22186835

    Citation

    Brock, Kaye E., et al. "Fruit, Vegetables, Fibre and Micronutrients and Risk of US Renal Cell Carcinoma." The British Journal of Nutrition, vol. 108, no. 6, 2012, pp. 1077-85.
    Brock KE, Ke L, Gridley G, et al. Fruit, vegetables, fibre and micronutrients and risk of US renal cell carcinoma. Br J Nutr. 2012;108(6):1077-85.
    Brock, K. E., Ke, L., Gridley, G., Chiu, B. C., Ershow, A. G., Lynch, C. F., ... Cantor, K. P. (2012). Fruit, vegetables, fibre and micronutrients and risk of US renal cell carcinoma. The British Journal of Nutrition, 108(6), pp. 1077-85. doi:10.1017/S0007114511006489.
    Brock KE, et al. Fruit, Vegetables, Fibre and Micronutrients and Risk of US Renal Cell Carcinoma. Br J Nutr. 2012 Sep 28;108(6):1077-85. PubMed PMID: 22186835.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruit, vegetables, fibre and micronutrients and risk of US renal cell carcinoma. AU - Brock,Kaye E, AU - Ke,Liang, AU - Gridley,Gloria, AU - Chiu,Brian C-H, AU - Ershow,Abby G, AU - Lynch,Charles F, AU - Graubard,Barry I, AU - Cantor,Kenneth P, Y1 - 2011/12/20/ PY - 2011/12/22/entrez PY - 2011/12/22/pubmed PY - 2012/12/10/medline SP - 1077 EP - 85 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 108 IS - 6 N2 - The association between renal cell cancer (RCC) and intake of fruit, vegetables and nutrients was examined in a population-based case-control study of 323 cases and 1827 controls; dietary intake was obtained using a mailed questionnaire. Cancer risks were estimated by OR and 95 % CI, adjusting for age, sex, smoking, obesity, hypertension, proxy status, alcohol consumption and dietary fat intake and energy. Intake of vegetables was associated with a decreased risk of RCC (OR 0·5; 95 % CI 0·3, 0·7; P trend = 0·002), (top compared to the bottom quartile of intake). When intake of individual nutrients was investigated, vegetable fibre intake was associated with decreased risks (OR 0·4; 95 % CI 0·2, 0·6; P < 0·001), but this was not the case with fruit fibre (OR 0·7; 95 % CI 0·4, 1·1) or grain fibre (OR 1·0; 95 % CI 0·6, 1·5). β-Cryptoxanthin and lycopene were also associated with decreased risks, but when both were included in a mutually adjusted backwards stepwise regression model, only β-cryptoxanthin remained significant (OR 0·5; 95 % CI 0·3, 0·8). When other micronutrients and types of fibre were investigated together, only vegetable fibre and β-cryptoxanthin had significant trends (P < 0·01) (OR 0·6; 95 % CI 0·3, 0·9) (OR 0·5; 95 % CI 0·3, 0·9), respectively. These findings were stronger in those aged over 65 years (P interaction = 0·001). Among non-smokers, low intake of cruciferous vegetables and fruit fibre was also associated with increased risk of RCC (P interaction = 0·03); similar inverse associations were found for β-cryptoxanthin, lycopene and vitamin C. When nutrients were mutually adjusted by backwards regression in these subgroups, only β-cryptoxanthin remained associated with lower RCC risk. These findings deserve further investigation in ongoing prospective studies when sample size becomes sufficient. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/22186835/Fruit_vegetables_fibre_and_micronutrients_and_risk_of_US_renal_cell_carcinoma_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511006489/type/journal_article DB - PRIME DP - Unbound Medicine ER -