Tags

Type your tag names separated by a space and hit enter

Efficacy of prophylactic intramuscular ephedrine in prevention of hypotension during caesarean section under spinal anaesthesia: a comparative study.
J Indian Med Assoc. 2011 May; 109(5):300-3, 307.JI

Abstract

Hypotension during caesarean section under spinal anaesthesia is a common complication. Several measures are used to reduce the incidence of hypotension but no method is fully effective. Prophylactic intramuscular ephedrine may be effective in reducing the incidence of hypotension in addition to conventional measures. To evaluate the efficacy of prophylactic intramuscular (IM) ephedrine (0.5 mg/kg, maximum up to 45 mg), given 10 minutes and 20 minutes before spinal anaesthesia to prevent hypotension, and to observe the adverse effects of IM ephedrine. A prospective, randomised, double-blind controlled study was undertaken where 150 pregnant mothers aged between 18 and 29 years and belonging to ASA physical status I, posted for elective caesarean section, were randomly allocated into one of the three groups. Group C received only preloading with 15 ml/kg of Ringer lactate (RL) solution, group E10 and group E20 received injection ephedrine 0.5 mg/kg IM 10 minutes and 20 minutes prior to performing spinal anaesthesia respectively along with 15 ml/kg RL preloading. The incidence of hypotension was significantly more in group C compared to other two groups. Mean arterial pressure and heart rate were significantly more in group E10 compared to group C. No significant increase in the incidence of hypertension and tachycardia in any group were observed. The findings of this study indicate that prophylactic IM ephedrine 0.5 mg/kg given 10 minutes before spinal anaesthesia gives better haemodynamic stability during intra-operative period without any significant increase in the incidence of adverse effects.

Authors+Show Affiliations

Department of Anaesthesiology, Midnapore Medical College & Hospital, Paschim Medinipur 721101.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22187760

Citation

Bhar, Debasish, et al. "Efficacy of Prophylactic Intramuscular Ephedrine in Prevention of Hypotension During Caesarean Section Under Spinal Anaesthesia: a Comparative Study." Journal of the Indian Medical Association, vol. 109, no. 5, 2011, pp. 300-3, 307.
Bhar D, Bharati S, Halder PS, et al. Efficacy of prophylactic intramuscular ephedrine in prevention of hypotension during caesarean section under spinal anaesthesia: a comparative study. J Indian Med Assoc. 2011;109(5):300-3, 307.
Bhar, D., Bharati, S., Halder, P. S., Mondal, S., Sarkar, M., & Jana, S. (2011). Efficacy of prophylactic intramuscular ephedrine in prevention of hypotension during caesarean section under spinal anaesthesia: a comparative study. Journal of the Indian Medical Association, 109(5), 300-3, 307.
Bhar D, et al. Efficacy of Prophylactic Intramuscular Ephedrine in Prevention of Hypotension During Caesarean Section Under Spinal Anaesthesia: a Comparative Study. J Indian Med Assoc. 2011;109(5):300-3, 307. PubMed PMID: 22187760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of prophylactic intramuscular ephedrine in prevention of hypotension during caesarean section under spinal anaesthesia: a comparative study. AU - Bhar,Debasish, AU - Bharati,Saswata, AU - Halder,Partha Sarathi, AU - Mondal,Subrata, AU - Sarkar,Malay, AU - Jana,Swapan, PY - 2011/12/23/entrez PY - 2011/12/23/pubmed PY - 2012/1/20/medline SP - 300-3, 307 JF - Journal of the Indian Medical Association JO - J Indian Med Assoc VL - 109 IS - 5 N2 - Hypotension during caesarean section under spinal anaesthesia is a common complication. Several measures are used to reduce the incidence of hypotension but no method is fully effective. Prophylactic intramuscular ephedrine may be effective in reducing the incidence of hypotension in addition to conventional measures. To evaluate the efficacy of prophylactic intramuscular (IM) ephedrine (0.5 mg/kg, maximum up to 45 mg), given 10 minutes and 20 minutes before spinal anaesthesia to prevent hypotension, and to observe the adverse effects of IM ephedrine. A prospective, randomised, double-blind controlled study was undertaken where 150 pregnant mothers aged between 18 and 29 years and belonging to ASA physical status I, posted for elective caesarean section, were randomly allocated into one of the three groups. Group C received only preloading with 15 ml/kg of Ringer lactate (RL) solution, group E10 and group E20 received injection ephedrine 0.5 mg/kg IM 10 minutes and 20 minutes prior to performing spinal anaesthesia respectively along with 15 ml/kg RL preloading. The incidence of hypotension was significantly more in group C compared to other two groups. Mean arterial pressure and heart rate were significantly more in group E10 compared to group C. No significant increase in the incidence of hypertension and tachycardia in any group were observed. The findings of this study indicate that prophylactic IM ephedrine 0.5 mg/kg given 10 minutes before spinal anaesthesia gives better haemodynamic stability during intra-operative period without any significant increase in the incidence of adverse effects. SN - 0019-5847 UR - https://www.unboundmedicine.com/medline/citation/22187760/Efficacy_of_prophylactic_intramuscular_ephedrine_in_prevention_of_hypotension_during_caesarean_section_under_spinal_anaesthesia:_a_comparative_study_ L2 - https://medlineplus.gov/cesareansection.html DB - PRIME DP - Unbound Medicine ER -