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[Contribution of the CoLaus study to decipher the determinants of serum uric acid].
Rev Med Suisse 2011; 7(315):2142, 2144-5RM

Abstract

Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far.

Authors+Show Affiliations

Institut de médecine sociale et préventive, CHUV, Route de la Corniche 2, 1066 Epalinges. Murielle.Bochud@chuv.chNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

22187784

Citation

Bochud, M, et al. "[Contribution of the CoLaus Study to Decipher the Determinants of Serum Uric Acid]." Revue Medicale Suisse, vol. 7, no. 315, 2011, pp. 2142, 2144-5.
Bochud M, Vollenweider P, Waeber G. [Contribution of the CoLaus study to decipher the determinants of serum uric acid]. Rev Med Suisse. 2011;7(315):2142, 2144-5.
Bochud, M., Vollenweider, P., & Waeber, G. (2011). [Contribution of the CoLaus study to decipher the determinants of serum uric acid]. Revue Medicale Suisse, 7(315), pp. 2142, 2144-5.
Bochud M, Vollenweider P, Waeber G. [Contribution of the CoLaus Study to Decipher the Determinants of Serum Uric Acid]. Rev Med Suisse. 2011 Nov 2;7(315):2142, 2144-5. PubMed PMID: 22187784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Contribution of the CoLaus study to decipher the determinants of serum uric acid]. AU - Bochud,M, AU - Vollenweider,P, AU - Waeber,G, PY - 2011/12/23/entrez PY - 2011/12/23/pubmed PY - 2012/2/9/medline SP - 2142, 2144-5 JF - Revue medicale suisse JO - Rev Med Suisse VL - 7 IS - 315 N2 - Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far. SN - 1660-9379 UR - https://www.unboundmedicine.com/medline/citation/22187784/[Contribution_of_the_CoLaus_study_to_decipher_the_determinants_of_serum_uric_acid]_ L2 - https://medlineplus.gov/gout.html DB - PRIME DP - Unbound Medicine ER -