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Mechanical strength of cortical allografts with gamma radiation versus ethylene oxide sterilization.
Acta Orthop Belg 2011; 77(5):670-5AO

Abstract

We investigated the effects of gamma irradiation versus ethylene oxide (ETO) sterilization on the mechanical strength of cortical bone grafts. Tibias were collected from cadavers of mature goats. Sixty test specimens were randomized into four groups: fresh (no processing), frozen (freezing at -70 degrees C), gamma-irradiated, and ETO-sterilized specimens. Torsion, three-point bending, and compression testing were separately performed with a material testing machine. Parameters studied included maximum stress, strain, deflection, extension, load, shear modulus, and E-modulus. Compared with findings for the fresh specimens, findings were as follows for gamma-irradiated specimens: maximal shear modulus, reduced by 48%; shear stress, by 55%; deflection, by 71%; bending stress, by 51%; bending strain, by 74%; extension, by 60%; and compression strain, by 50%. However, there were no reductions in those parameters for the frozen specimens or the ETO-sterilized specimens. These findings confirm that shear, bending, and compression strength of cortical allografts are weakened by gamma irradiation at room temperature. To maintain optimum mechanical properties, ETO sterilization of allografts is better than gamma sterilization, especially for cortical bone, because it is usually used in load-bearing settings.

Authors+Show Affiliations

Department of Orthopaedic Surgery, West China Hospital of Sichuan University, Chengdu, China. zhouzongke@scu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22187845

Citation

Zhou, Zongke, et al. "Mechanical Strength of Cortical Allografts With Gamma Radiation Versus Ethylene Oxide Sterilization." Acta Orthopaedica Belgica, vol. 77, no. 5, 2011, pp. 670-5.
Zhou Z, Qin T, Yang J, et al. Mechanical strength of cortical allografts with gamma radiation versus ethylene oxide sterilization. Acta Orthop Belg. 2011;77(5):670-5.
Zhou, Z., Qin, T., Yang, J., Shen, B., Kang, P., & Peil, F. (2011). Mechanical strength of cortical allografts with gamma radiation versus ethylene oxide sterilization. Acta Orthopaedica Belgica, 77(5), pp. 670-5.
Zhou Z, et al. Mechanical Strength of Cortical Allografts With Gamma Radiation Versus Ethylene Oxide Sterilization. Acta Orthop Belg. 2011;77(5):670-5. PubMed PMID: 22187845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanical strength of cortical allografts with gamma radiation versus ethylene oxide sterilization. AU - Zhou,Zongke, AU - Qin,Tingwu, AU - Yang,Jing, AU - Shen,Bin, AU - Kang,Pengde, AU - Peil,Fuxing, PY - 2011/12/23/entrez PY - 2011/12/23/pubmed PY - 2012/1/18/medline SP - 670 EP - 5 JF - Acta orthopaedica Belgica JO - Acta Orthop Belg VL - 77 IS - 5 N2 - We investigated the effects of gamma irradiation versus ethylene oxide (ETO) sterilization on the mechanical strength of cortical bone grafts. Tibias were collected from cadavers of mature goats. Sixty test specimens were randomized into four groups: fresh (no processing), frozen (freezing at -70 degrees C), gamma-irradiated, and ETO-sterilized specimens. Torsion, three-point bending, and compression testing were separately performed with a material testing machine. Parameters studied included maximum stress, strain, deflection, extension, load, shear modulus, and E-modulus. Compared with findings for the fresh specimens, findings were as follows for gamma-irradiated specimens: maximal shear modulus, reduced by 48%; shear stress, by 55%; deflection, by 71%; bending stress, by 51%; bending strain, by 74%; extension, by 60%; and compression strain, by 50%. However, there were no reductions in those parameters for the frozen specimens or the ETO-sterilized specimens. These findings confirm that shear, bending, and compression strength of cortical allografts are weakened by gamma irradiation at room temperature. To maintain optimum mechanical properties, ETO sterilization of allografts is better than gamma sterilization, especially for cortical bone, because it is usually used in load-bearing settings. SN - 0001-6462 UR - https://www.unboundmedicine.com/medline/citation/22187845/Mechanical_strength_of_cortical_allografts_with_gamma_radiation_versus_ethylene_oxide_sterilization_ L2 - https://medlineplus.gov/bonegrafts.html DB - PRIME DP - Unbound Medicine ER -