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Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year.
Allergy. 2012 Mar; 67(3):380-9.A

Abstract

BACKGROUND

Regulatory T cells (Tregs) with stable FOXP3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg-specific demethylated region, TSDR). The aim of this study was to analyse the influence of prenatal factors on cord blood Treg numbers, as detected by changes in the TSDR demethylation, and the subsequent risk for allergic diseases.

METHODS

Analyses were performed within the LINA study in blood samples from pregnant women (34th gestational week) and in cord blood (n = 346 mother-child pairs). Treg numbers were detected via DNA demethylation in the FOXP3 TSDR. At age 1, total and specific IgE was measured in children's blood. In addition, maternal cytokine production (Th1/Th2/Th17) was analysed. Exposure and disease outcomes were assessed by questionnaires.

RESULTS

Boys had lower Treg numbers compared with girls (P < 0.001). Parental atopy history, particularly maternal hay fever and paternal asthma were related to lower Treg numbers in cord blood (adj. MR = 0.81, 95% CI = 0.68-0.97; adj. MR = 0.60, 95% CI = 0.45-0.81). Maternal cytokines (IL-13, IL-17E and IFN-γ) and maternal smoking/exposure to tobacco smoke during pregnancy were also associated with decreased cord blood Treg numbers (adj. MR = 0.89, 95% CI = 0.97-1.00). Children with lower Treg numbers at birth had a higher risk to develop atopic dermatitis (adj. OR = 1.55, 95% CI = 1.00-2.41) and sensitization to food allergens (adj. OR = 1.55, 95% CI = 1.06-2.25) during the first year of life.

CONCLUSIONS

These results indicate that both genetic and environmental factors presumably influence the development of foetal Tregs. Low cord blood Treg numbers may predict early atopic dermatitis.

Authors+Show Affiliations

Department of Environmental Immunology, UFZ - Helmholtz Centre for Environmental Research Leipzig, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22187950

Citation

Hinz, D, et al. "Cord Blood Tregs With Stable FOXP3 Expression Are Influenced By Prenatal Environment and Associated With Atopic Dermatitis at the Age of One Year." Allergy, vol. 67, no. 3, 2012, pp. 380-9.
Hinz D, Bauer M, Röder S, et al. Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. Allergy. 2012;67(3):380-9.
Hinz, D., Bauer, M., Röder, S., Olek, S., Huehn, J., Sack, U., Borte, M., Simon, J. C., Lehmann, I., & Herberth, G. (2012). Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. Allergy, 67(3), 380-9. https://doi.org/10.1111/j.1398-9995.2011.02767.x
Hinz D, et al. Cord Blood Tregs With Stable FOXP3 Expression Are Influenced By Prenatal Environment and Associated With Atopic Dermatitis at the Age of One Year. Allergy. 2012;67(3):380-9. PubMed PMID: 22187950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. AU - Hinz,D, AU - Bauer,M, AU - Röder,S, AU - Olek,S, AU - Huehn,J, AU - Sack,U, AU - Borte,M, AU - Simon,J C, AU - Lehmann,I, AU - Herberth,G, AU - ,, Y1 - 2011/12/22/ PY - 2011/11/15/accepted PY - 2011/12/23/entrez PY - 2011/12/23/pubmed PY - 2012/6/12/medline SP - 380 EP - 9 JF - Allergy JO - Allergy VL - 67 IS - 3 N2 - BACKGROUND: Regulatory T cells (Tregs) with stable FOXP3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg-specific demethylated region, TSDR). The aim of this study was to analyse the influence of prenatal factors on cord blood Treg numbers, as detected by changes in the TSDR demethylation, and the subsequent risk for allergic diseases. METHODS: Analyses were performed within the LINA study in blood samples from pregnant women (34th gestational week) and in cord blood (n = 346 mother-child pairs). Treg numbers were detected via DNA demethylation in the FOXP3 TSDR. At age 1, total and specific IgE was measured in children's blood. In addition, maternal cytokine production (Th1/Th2/Th17) was analysed. Exposure and disease outcomes were assessed by questionnaires. RESULTS: Boys had lower Treg numbers compared with girls (P < 0.001). Parental atopy history, particularly maternal hay fever and paternal asthma were related to lower Treg numbers in cord blood (adj. MR = 0.81, 95% CI = 0.68-0.97; adj. MR = 0.60, 95% CI = 0.45-0.81). Maternal cytokines (IL-13, IL-17E and IFN-γ) and maternal smoking/exposure to tobacco smoke during pregnancy were also associated with decreased cord blood Treg numbers (adj. MR = 0.89, 95% CI = 0.97-1.00). Children with lower Treg numbers at birth had a higher risk to develop atopic dermatitis (adj. OR = 1.55, 95% CI = 1.00-2.41) and sensitization to food allergens (adj. OR = 1.55, 95% CI = 1.06-2.25) during the first year of life. CONCLUSIONS: These results indicate that both genetic and environmental factors presumably influence the development of foetal Tregs. Low cord blood Treg numbers may predict early atopic dermatitis. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/22187950/Cord_blood_Tregs_with_stable_FOXP3_expression_are_influenced_by_prenatal_environment_and_associated_with_atopic_dermatitis_at_the_age_of_one_year_ L2 - https://doi.org/10.1111/j.1398-9995.2011.02767.x DB - PRIME DP - Unbound Medicine ER -