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Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis.
J Oral Pathol Med. 2012 Jul; 41(6):500-4.JO

Abstract

BACKGROUND

Atrophic glossitis (AG) is considered to be a marker of nutritional deficiency. In this study, we evaluated whether there was an intimate association of the deficiency of hemoglobin, iron, vitamin B12 or folic acid, high blood homocysteine level, and serum gastric parietal cell antibody (GPCA) positivity with AG.

METHODS

The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations and the serum GPCA level in 176 AG patients were measured and compared with the corresponding levels in 176 age- and sex-matched healthy control subjects.

RESULTS

We found that 39 (22.2%), 47 (26.7%), 13 (7.4%), and 3 (1.7%) AG patients had deficiencies of Hb (men < 13 g/dl, women < 12 g/dl), iron (<60 μg/dl), vitamin B12 (<200 pg/ml), and folic acid (<4 ng/ml), respectively. Moreover, 38 (21.6%) AG patients had abnormally high blood homocysteine level, and 47 (26.7%) AG patients had serum GPCA positivity. AG patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, or of serum GPCA positivity than healthy control subjects (all P-values = 0.000). However, no significant difference in frequency of folic acid deficiency was found between AG patients and healthy control subjects.

CONCLUSION

We conclude that there is a significant association of deficiency of hemoglobin, iron and vitamin B12, abnormally high blood homocysteine level, and serum GPCA positivity with AG.

Authors+Show Affiliations

Department of Dentistry, School of Dentistry, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22188475

Citation

Sun, Andy, et al. "Significant Association of Deficiency of Hemoglobin, Iron and Vitamin B12, High Homocysteine Level, and Gastric Parietal Cell Antibody Positivity With Atrophic Glossitis." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 41, no. 6, 2012, pp. 500-4.
Sun A, Lin HP, Wang YP, et al. Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. J Oral Pathol Med. 2012;41(6):500-4.
Sun, A., Lin, H. P., Wang, Y. P., & Chiang, C. P. (2012). Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 41(6), 500-4. https://doi.org/10.1111/j.1600-0714.2011.01122.x
Sun A, et al. Significant Association of Deficiency of Hemoglobin, Iron and Vitamin B12, High Homocysteine Level, and Gastric Parietal Cell Antibody Positivity With Atrophic Glossitis. J Oral Pathol Med. 2012;41(6):500-4. PubMed PMID: 22188475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. AU - Sun,Andy, AU - Lin,Hung-Pin, AU - Wang,Yi-Ping, AU - Chiang,Chun-Pin, Y1 - 2011/12/22/ PY - 2011/12/23/entrez PY - 2011/12/23/pubmed PY - 2013/1/9/medline SP - 500 EP - 4 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 41 IS - 6 N2 - BACKGROUND: Atrophic glossitis (AG) is considered to be a marker of nutritional deficiency. In this study, we evaluated whether there was an intimate association of the deficiency of hemoglobin, iron, vitamin B12 or folic acid, high blood homocysteine level, and serum gastric parietal cell antibody (GPCA) positivity with AG. METHODS: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations and the serum GPCA level in 176 AG patients were measured and compared with the corresponding levels in 176 age- and sex-matched healthy control subjects. RESULTS: We found that 39 (22.2%), 47 (26.7%), 13 (7.4%), and 3 (1.7%) AG patients had deficiencies of Hb (men < 13 g/dl, women < 12 g/dl), iron (<60 μg/dl), vitamin B12 (<200 pg/ml), and folic acid (<4 ng/ml), respectively. Moreover, 38 (21.6%) AG patients had abnormally high blood homocysteine level, and 47 (26.7%) AG patients had serum GPCA positivity. AG patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, or of serum GPCA positivity than healthy control subjects (all P-values = 0.000). However, no significant difference in frequency of folic acid deficiency was found between AG patients and healthy control subjects. CONCLUSION: We conclude that there is a significant association of deficiency of hemoglobin, iron and vitamin B12, abnormally high blood homocysteine level, and serum GPCA positivity with AG. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/22188475/Significant_association_of_deficiency_of_hemoglobin_iron_and_vitamin_B12_high_homocysteine_level_and_gastric_parietal_cell_antibody_positivity_with_atrophic_glossitis_ L2 - https://doi.org/10.1111/j.1600-0714.2011.01122.x DB - PRIME DP - Unbound Medicine ER -