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The dominance of human coronavirus OC43 and NL63 infections in infants.
J Clin Virol. 2012 Feb; 53(2):135-9.JC

Abstract

BACKGROUND

It is unknown to what extent the human coronaviruses (HCoVs) OC43, HKU1, 229E and NL63 infect healthy children. Frequencies of infections are only known for hospitalized children.

OBJECTIVES

Comparing infection frequencies in children who have mild infections with frequencies in children needing hospital uptake will determine whether infection by one of the four HCoVs leads to more severe disease. In addition, the sequence of seroconversions can reveal whether infection by one HCoV protects from infection by other HCoVs.

STUDY DESIGN

Two distinct study groups were monitored: healthy children and children hospitalized due to respiratory infection. HCoV natural infection rates in healthy children were obtained by serology in 25 newborns (followed 0-20months). The frequencies of severe HCoVs infection was determined by real time RT-PCR among 1471 hospitalized infants (<2-years old) with acute respiratory tract disease.

RESULTS

The majority of healthy children seroconverted for HCoV-OC43 (n=19) and HCoV-NL63 (n=17), less for HCoV-HKU1 (n=9) and HCoV-229E (n=5). Notably, HCoV-HKU1 seroconversion was absent after HCoV-OC43 infection. Also HCoV-229E infection was rarely observed after HCoV-NL63 infection (1 out of 5). In the hospital 207 (14%) out of 1471 children were HCoV positive. Again we observed most infection by HCoV-OC43 (n=85) and HCoV-NL63 (n=60), followed by HCoV-HKU1 (n=47) and HCoV-229E (n=15).

CONCLUSIONS

HCoV-NL63 and HCoV-OC43 infections occur frequently in early childhood, more often than HCoV-HKU1 or HCoV-229E infections. HCoV-OC43 and HCoV-NL63 may elicit immunity that protects from subsequent HCoV-HKU1 and HCoV-229E infection, respectively, which would explain why HCoV-OC43 and HCoV-NL63 are the most frequently infecting HCoVs. There are no indications that infection by one of the HCoVs is more pathogenic than others.

Authors+Show Affiliations

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22188723

Citation

Dijkman, Ronald, et al. "The Dominance of Human Coronavirus OC43 and NL63 Infections in Infants." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 53, no. 2, 2012, pp. 135-9.
Dijkman R, Jebbink MF, Gaunt E, et al. The dominance of human coronavirus OC43 and NL63 infections in infants. J Clin Virol. 2012;53(2):135-9.
Dijkman, R., Jebbink, M. F., Gaunt, E., Rossen, J. W., Templeton, K. E., Kuijpers, T. W., & van der Hoek, L. (2012). The dominance of human coronavirus OC43 and NL63 infections in infants. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 53(2), 135-9. https://doi.org/10.1016/j.jcv.2011.11.011
Dijkman R, et al. The Dominance of Human Coronavirus OC43 and NL63 Infections in Infants. J Clin Virol. 2012;53(2):135-9. PubMed PMID: 22188723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The dominance of human coronavirus OC43 and NL63 infections in infants. AU - Dijkman,Ronald, AU - Jebbink,Maarten F, AU - Gaunt,Eleanor, AU - Rossen,John W A, AU - Templeton,Kate E, AU - Kuijpers,Taco W, AU - van der Hoek,Lia, Y1 - 2011/12/19/ PY - 2011/10/12/received PY - 2011/11/12/revised PY - 2011/11/22/accepted PY - 2011/12/23/entrez PY - 2011/12/23/pubmed PY - 2012/5/16/medline SP - 135 EP - 9 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 53 IS - 2 N2 - BACKGROUND: It is unknown to what extent the human coronaviruses (HCoVs) OC43, HKU1, 229E and NL63 infect healthy children. Frequencies of infections are only known for hospitalized children. OBJECTIVES: Comparing infection frequencies in children who have mild infections with frequencies in children needing hospital uptake will determine whether infection by one of the four HCoVs leads to more severe disease. In addition, the sequence of seroconversions can reveal whether infection by one HCoV protects from infection by other HCoVs. STUDY DESIGN: Two distinct study groups were monitored: healthy children and children hospitalized due to respiratory infection. HCoV natural infection rates in healthy children were obtained by serology in 25 newborns (followed 0-20months). The frequencies of severe HCoVs infection was determined by real time RT-PCR among 1471 hospitalized infants (<2-years old) with acute respiratory tract disease. RESULTS: The majority of healthy children seroconverted for HCoV-OC43 (n=19) and HCoV-NL63 (n=17), less for HCoV-HKU1 (n=9) and HCoV-229E (n=5). Notably, HCoV-HKU1 seroconversion was absent after HCoV-OC43 infection. Also HCoV-229E infection was rarely observed after HCoV-NL63 infection (1 out of 5). In the hospital 207 (14%) out of 1471 children were HCoV positive. Again we observed most infection by HCoV-OC43 (n=85) and HCoV-NL63 (n=60), followed by HCoV-HKU1 (n=47) and HCoV-229E (n=15). CONCLUSIONS: HCoV-NL63 and HCoV-OC43 infections occur frequently in early childhood, more often than HCoV-HKU1 or HCoV-229E infections. HCoV-OC43 and HCoV-NL63 may elicit immunity that protects from subsequent HCoV-HKU1 and HCoV-229E infection, respectively, which would explain why HCoV-OC43 and HCoV-NL63 are the most frequently infecting HCoVs. There are no indications that infection by one of the HCoVs is more pathogenic than others. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/22188723/The_dominance_of_human_coronavirus_OC43_and_NL63_infections_in_infants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(11)00473-2 DB - PRIME DP - Unbound Medicine ER -