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Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion.
J Invest Dermatol. 2012 Apr; 132(4):1222-9.JI

Abstract

Recent studies have described the role of shedding vesicles as physiological conveyers of intracellular components between neighboring cells. Here we report that melanosomes are one example of shedding vesicle cargo, but are processed by a previously unreported mechanism. Pigment globules were observed to be connected to the filopodia of melanocyte dendrites, which have previously been shown to be conduits for melanosomes. Pigment globules containing multiple melanosomes were released from various areas of the dendrites of normal human melanocytes derived from darkly pigmented skin. The globules were then captured by the microvilli of normal human keratinocytes, also derived from darkly pigmented skin, which incorporated them in a protease-activated receptor-2 (PAR-2)-dependent manner. After the pigment globules were ingested by the keratinocytes, the membrane that surrounded each melanosome cluster was gradually degraded, and the individual melanosomes then spread into the cytosol and were distributed primarily in the perinuclear area of each keratinocyte. These results suggest a melanosome transfer pathway wherein melanosomes are transferred from melanocytes to keratinocytes via the shedding vesicle system. This packaging system generates pigment globules containing multiple melanosomes in a unique manner.

Links

Publisher Full Text
linkinghub.elsevier.com
linkinghub.elsevier.com

Authors+Show Affiliations

Ando H
Department of Applied Chemistry and Biotechnology, Okayama University of Science, Okayama, Japan. ando@dac.ous.ac.jp
Niki Y
No affiliation info available
Ito M
No affiliation info available
Akiyama K
No affiliation info available
Matsui MS
No affiliation info available
Yarosh DB
No affiliation info available
Ichihashi M
No affiliation info available

MeSH

Biological TransportCell MembraneCell Membrane PermeabilityCells, CulturedHumansKeratinocytesMaleMelanocytesMelanosomesMicrovilliPigmentationReceptor, PAR-2Transport Vesicles

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22189785

Citation

Ando, Hideya, et al. "Melanosomes Are Transferred From Melanocytes to Keratinocytes Through the Processes of Packaging, Release, Uptake, and Dispersion." The Journal of Investigative Dermatology, vol. 132, no. 4, 2012, pp. 1222-9.
Ando H, Niki Y, Ito M, et al. Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion. J Invest Dermatol. 2012;132(4):1222-9.
Ando, H., Niki, Y., Ito, M., Akiyama, K., Matsui, M. S., Yarosh, D. B., & Ichihashi, M. (2012). Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion. The Journal of Investigative Dermatology, 132(4), 1222-9. https://doi.org/10.1038/jid.2011.413
Ando H, et al. Melanosomes Are Transferred From Melanocytes to Keratinocytes Through the Processes of Packaging, Release, Uptake, and Dispersion. J Invest Dermatol. 2012;132(4):1222-9. PubMed PMID: 22189785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion. AU - Ando,Hideya, AU - Niki,Yoko, AU - Ito,Masaaki, AU - Akiyama,Kaoru, AU - Matsui,Mary S, AU - Yarosh,Daniel B, AU - Ichihashi,Masamitsu, Y1 - 2011/12/22/ PY - 2011/12/23/entrez PY - 2011/12/23/pubmed PY - 2012/5/23/medline SP - 1222 EP - 9 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 132 IS - 4 N2 - Recent studies have described the role of shedding vesicles as physiological conveyers of intracellular components between neighboring cells. Here we report that melanosomes are one example of shedding vesicle cargo, but are processed by a previously unreported mechanism. Pigment globules were observed to be connected to the filopodia of melanocyte dendrites, which have previously been shown to be conduits for melanosomes. Pigment globules containing multiple melanosomes were released from various areas of the dendrites of normal human melanocytes derived from darkly pigmented skin. The globules were then captured by the microvilli of normal human keratinocytes, also derived from darkly pigmented skin, which incorporated them in a protease-activated receptor-2 (PAR-2)-dependent manner. After the pigment globules were ingested by the keratinocytes, the membrane that surrounded each melanosome cluster was gradually degraded, and the individual melanosomes then spread into the cytosol and were distributed primarily in the perinuclear area of each keratinocyte. These results suggest a melanosome transfer pathway wherein melanosomes are transferred from melanocytes to keratinocytes via the shedding vesicle system. This packaging system generates pigment globules containing multiple melanosomes in a unique manner. SN - 1523-1747 UR - https://www.unboundmedicine.com/medline/citation/22189785/Melanosomes_are_transferred_from_melanocytes_to_keratinocytes_through_the_processes_of_packaging_release_uptake_and_dispersion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-202X(15)35689-X DB - PRIME DP - Unbound Medicine ER -