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Enteral feeding induces early intestinal adaptation in a parenterally fed neonatal piglet model of short bowel syndrome.
JPEN J Parenter Enteral Nutr. 2012 Mar; 36(2):205-12.JJ

Abstract

BACKGROUND

Successful small intestinal (SI) adaptation following surgical resection is essential for optimizing newborn growth and development, but the potential for adaptation is unknown. The authors developed an SI resection model in neonatal piglets supported by intravenous and enteral nutrition.

METHODS

Piglets (n = 33, 12-13 days old) were randomized to 80% SI resection with parenteral nutrition feeding (R-PN), 80% SI resection with PN + enteral feeding (R-EN), or sham SI transection with PN + enteral feeding (sham-EN). In resected pigs, the distal 100 cm of ileum (residual SI) and 30 cm of proximal SI were left intact. All pigs received parenteral nutrition postsurgery. Enteral nutrition piglets received continuous gastric infusion of elemental diet from day 3 (40:60 parenteral nutrition:enteral nutrition). Piglets were killed 4, 6, or 10 days postsurgery.

RESULTS

By 10 days, R-EN piglets had longer residual SI than R-PN and sham-EN pigs (P < .05). At days 6 and 10, R-EN piglets had greater weight per length of intact SI (P < .05) and isolated mucosa (P < .05) compared to other groups. Greater gut weight in R-EN piglets was facilitated by a greater cellular proliferation index (P < .01) by 4 days compared to other groups and greater overall ornithine decarboxylase activity vs R-PN piglets (P < .05).

CONCLUSIONS

This new model demonstrated profound SI adaptation, initiated early postsurgery by polyamine synthesis and crypt cell proliferation and only in response to enteral feeding. These changes translated to greater gut mass and length within days, likely improving functional capacity long term.

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Authors+Show Affiliations

Dodge ME
Department of Biochemistry, Memorial University of Newfoundland, St John's, Newfoundland and Labrador, Canada.
Bertolo RF
No affiliation info available
Brunton JA
No affiliation info available

MeSH

Adaptation, PhysiologicalAnimalsAnimals, NewbornCell ProliferationDisease Models, AnimalEnteral NutritionIleumIntestinal MucosaIntestine, SmallOrgan SizeOrnithine DecarboxylaseParenteral NutritionRandom AllocationShort Bowel SyndromeSwine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22190604

Citation

Dodge, M Elaine, et al. "Enteral Feeding Induces Early Intestinal Adaptation in a Parenterally Fed Neonatal Piglet Model of Short Bowel Syndrome." JPEN. Journal of Parenteral and Enteral Nutrition, vol. 36, no. 2, 2012, pp. 205-12.
Dodge ME, Bertolo RF, Brunton JA. Enteral feeding induces early intestinal adaptation in a parenterally fed neonatal piglet model of short bowel syndrome. JPEN J Parenter Enteral Nutr. 2012;36(2):205-12.
Dodge, M. E., Bertolo, R. F., & Brunton, J. A. (2012). Enteral feeding induces early intestinal adaptation in a parenterally fed neonatal piglet model of short bowel syndrome. JPEN. Journal of Parenteral and Enteral Nutrition, 36(2), 205-12. https://doi.org/10.1177/0148607111417447
Dodge ME, Bertolo RF, Brunton JA. Enteral Feeding Induces Early Intestinal Adaptation in a Parenterally Fed Neonatal Piglet Model of Short Bowel Syndrome. JPEN J Parenter Enteral Nutr. 2012;36(2):205-12. PubMed PMID: 22190604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enteral feeding induces early intestinal adaptation in a parenterally fed neonatal piglet model of short bowel syndrome. AU - Dodge,M Elaine, AU - Bertolo,Robert F, AU - Brunton,Janet A, Y1 - 2011/12/21/ PY - 2011/12/23/entrez PY - 2011/12/23/pubmed PY - 2012/7/28/medline SP - 205 EP - 12 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 36 IS - 2 N2 - BACKGROUND: Successful small intestinal (SI) adaptation following surgical resection is essential for optimizing newborn growth and development, but the potential for adaptation is unknown. The authors developed an SI resection model in neonatal piglets supported by intravenous and enteral nutrition. METHODS: Piglets (n = 33, 12-13 days old) were randomized to 80% SI resection with parenteral nutrition feeding (R-PN), 80% SI resection with PN + enteral feeding (R-EN), or sham SI transection with PN + enteral feeding (sham-EN). In resected pigs, the distal 100 cm of ileum (residual SI) and 30 cm of proximal SI were left intact. All pigs received parenteral nutrition postsurgery. Enteral nutrition piglets received continuous gastric infusion of elemental diet from day 3 (40:60 parenteral nutrition:enteral nutrition). Piglets were killed 4, 6, or 10 days postsurgery. RESULTS: By 10 days, R-EN piglets had longer residual SI than R-PN and sham-EN pigs (P < .05). At days 6 and 10, R-EN piglets had greater weight per length of intact SI (P < .05) and isolated mucosa (P < .05) compared to other groups. Greater gut weight in R-EN piglets was facilitated by a greater cellular proliferation index (P < .01) by 4 days compared to other groups and greater overall ornithine decarboxylase activity vs R-PN piglets (P < .05). CONCLUSIONS: This new model demonstrated profound SI adaptation, initiated early postsurgery by polyamine synthesis and crypt cell proliferation and only in response to enteral feeding. These changes translated to greater gut mass and length within days, likely improving functional capacity long term. SN - 1941-2444 UR - https://www.unboundmedicine.com/medline/citation/22190604/Enteral_feeding_induces_early_intestinal_adaptation_in_a_parenterally_fed_neonatal_piglet_model_of_short_bowel_syndrome_ L2 - https://doi.org/10.1177/0148607111417447 DB - PRIME DP - Unbound Medicine ER -